World Wide Uncharted Trajectory Outbreak Initiator: Coronavirus [COVID-19] Pathogenesis
Gajula Chinna Devi1
- 1Department of Pharmaceutics, University College of Pharmaceutical Sciences, Palamuru University, Mahabub Nagar, Telangana, INDIA.
CORRESPONDENCE
Received: 15-04-2020; Revised: 02-08-2020; Accepted: 18-12-2020.
Volume 55, Issue 1 · pp. 11–20 · PUBLISHED 2021 · DOI: 10.5530/ijper.55.1.4
ABSTRACT
The Coronavirus (CoV) belongs to family of Coronaviridae, suborder Coronavirinae and Nidovirales order. CoV causes diseases in human with a just cold, cough and high fever symptoms simultaneously develops in to severe respiratory syndrome and ceases fatal. The source of virus is believed to be “Wet Market” in Wuhan, China. The source of the latest pandemic has not yet been identified exactly but the original host is expected to be bats and mammals, which are host of wide range of Zoonotic viruses. The current trajectory state defines the virus is climbing rest of the world. The article is a descriptive study of CoV types, origin, transmission of virus from bats, mammals and inanimate surfaces to the host cells, life cycle of coronavirus where the Spike protein (S1 and S2) domains fusing with the receptors present on the host cell and other mechanisms. Steps of translation and exocytosis represented diagrammatically to control and mitigate the fatality. Worldwide therapy of the patients, a glance report on drug developments, stage of clinical trials and vaccine research is reported.
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Devi, G. C. (2021). World Wide Uncharted Trajectory Outbreak Initiator: Coronavirus [COVID-19] Pathogenesis. Indian Journal of Pharmaceutical Education and Research, 55(1), 11–20. https://doi.org/10.5530/ijper.55.1.4