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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Antioxidant and Anti-inflammatory Activity Screening of Lasia spinosa Rhizome and its Validation using a Computational Simulation Approach

Arya Lakshmi Marisetti1★, Mohan Gandhi Bonthu2, Ganga Rao Battu1★ Corresponding author

  1. 1Pharmacognosy and Phytochemistry Research Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.
  2. 2Department of Pharmaceutical Analysis, Sri Vasavi Institute of Pharmaceutical Sciences, Tadepalliguem, Andhra Pradesh, INDIA.

CORRESPONDENCE

Arya Lakshmi Marisetti

Pharmacognosy and Phytochemistry Research Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

maryalakshmi@gmail.com

Received: 11-05-2020; Revised: 17-07-2020; Accepted: 26-10-2020.

Volume 54, Issue 4 · pp. 1109–1120 · PUBLISHED 2020 · DOI: 10.5530/ijper.54.4.207

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ABSTRACT

Background: The present work assesses the antioxidant and anti-inflammatory effect of Lasia spinosa rhizome extracts on in-vitro and in-vivo models compiled through molecular docking study of plant-steemed phytocompounds with specific targets. Materials and Methods: In this study, Lasia spinosa rhizome was subjected to extraction using petroleum ether, ethyl acetate and methanol and the extracts were analyzed by GC-MS. Antioxidant was assessed using in-vitro methods such as DPPH scavenging activity and H2O2 scavenging activity; anti-inflammatory activity was assessed using both in-vitro and in-vivo and molecular docking utilizing Auto dock 4.0 was done. Results: Tests showed that methanolic extract (MELS) has the most important dose-dependent antioxidant and anti-inflammatory efficacy at various levels. Of all compounds, Morin reported the most successful docking ranking of -8.2 to -9.8, maintaining a good binding fondness between protein and ligand. Conclusion: Antioxidant and anti-inflammatory of Lasia spinosa may be inferred from the examinations. The in-vitro, in-vivo and in silico assays of L. spinosa. Morin is confirmed by the information as a beneficial antioxidant and anti-inflammatory agent that can aid future clinical assessments.

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    Marisetti, A. L., Bonthu, M. G., & Battu, G. R. (2020). Antioxidant and Anti-inflammatory Activity Screening of Lasia spinosa Rhizome and its Validation using a Computational Simulation Approach. Indian Journal of Pharmaceutical Education and Research, 54(4), 1109–1120. https://doi.org/10.5530/ijper.54.4.207