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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Investigation of Effect of Phytoconstituents Aloe Emodin and Quercetin on Bioavailability of Albendazole

Harsh Verma1, Ravindra Kumar Pandey1★, Shiv Shankar Shukla2, Bina Gidwani2, Amber Vyas3★ Corresponding author

  1. 1Department of Pharmacognosy, Columbia Institute of Pharmacy Tekari, Raipur, Chhattisgarh, INDIA.
  2. 2Department of Pharmaceutical Analysis and Quality Assurance, Columbia Institute of Pharmacy Tekari, Chhattisgarh, INDIA.
  3. 3Department of Pharmaceutics, University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, INDIA.

CORRESPONDENCE

Ravindra Kumar Pandey

Department of Pharmacognosy, Columbia Institute of Pharmacy Tekari, Raipur, Chhattisgarh, INDIA.

ravindraiop@gmail.com

Received: 14-12-2019; Revised: 29-05-2020; Accepted: 13-08-2020.

Volume 54, Issue 4 · pp. 991–998 · PUBLISHED 2020 · DOI: 10.5530/ijper.54.4.193

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ABSTRACT

Background/Aim: Albendazole is a drug with benzimidazole nucleus and is poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. The objective of present work was to study the effect of two phytoconstituents aloe emodin and quercetin on the bioavailability of albendazole. Materials and Methods: Estimation was done through UV spectroscopy and HPLC analysis using different concentration of both the phytoconstituents. In-vivo study was conducted to investigate the pharmacokinetics and pharmacodynamic parameters. Results: Results revealed no change in Tmax of albendazole and significant changes were observed in Cmax values. The Cmax was maximum i.e. 0.138 μg/ml when 20mg/kg of quercetin was added as compared to aloe-emodin. The increase in bioavailability of Albendazole was due to the presence of flavonoids in quercetin. The retention time of albendazole as estimated through HPLC chromatogram was found to be 3.2 minutes with acetonitrile and phosphate buffer as the mobile phase. However; albendazole was not detectable in 24 hr plasma sample and values of AUC were found to be zero in all the concentration of aloe emodin and quercetin. Conclusion: Thus, the phytoconstituents rich in flavonoids could be used to increase the bioavailability of poor soluble drugs.

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    Verma, H., Pandey, R. K., Shukla, S. S., Gidwani, B., & Vyas, A. (2020). Investigation of Effect of Phytoconstituents Aloe Emodin and Quercetin on Bioavailability of Albendazole. Indian Journal of Pharmaceutical Education and Research, 54(4), 991–998. https://doi.org/10.5530/ijper.54.4.193