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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Neuroprotective effect of 1, 3-β-glucan-curcumin mixing (Bioglucur) on Alzheimer Disease Induced in Mice by Aluminium Toxicity

Nesrine Ouda Amari1, Noureddine Djebli1★, Le Mai Huong2, Tran Thi Hong Ha2, Nguyen Dinh Luyen2, Vu Thi Bich3,4★ Corresponding author

  1. 1Laboratory of Pharmacognosy and Api Phytotherapy, University of Mostaganem, Mostaganem, ALGERIA.
  2. 2Institute of Natural Products Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), Hoang Quoc Viet, Caugiay, Hanoi, VIETNAM.
  3. 3Institute of Theoretical and Applied Research, Duy Tan University, Hanoi, VIETNAM.
  4. 4Institute of Physics (IOP), Vietnam Academy of Science and technology (VAST), Dao Tan, Ba Dinh, Hanoi, VIETNAM.

CORRESPONDENCE

Noureddine Djebli

Laboratory of Pharmacognosy and Api Phytotherapy, University of Mostaganem, Mostaganem, ALGERIA.

noureddine.djebli27@gmail.com

Received: 06-05-2020; Revised: 14-07-2020; Accepted: 23-09-2020.

Volume 54, Issue 4 · pp. 1089–1097 · PUBLISHED 2020 · DOI: 10.5530/ijper.54.4.204

View on IJPER original site ↗

ABSTRACT

Aim: The aim of this study was to evaluate the neuroprotective effect of oral administration of acomplex of curcumin with 1,3-β-glucan extracted from Vietnamese mushrooms named Bioglucur to increase drug delivery efficiency and biological effectin Alzheimer’s model mice. Materials and Methods: Alzheimer’s disease was induced in mice and treated in parallel by Bioglucur. Results: Results obtained show that the Bioglucur improves impart mental concentration and memory and decrease anxiety thus the storage capacity is improved during the Morris test and even neurons improvement in the histological study in treated mice. Conclusion: The mixture preparation of curcumin and 1,3-β-glucans from Vietnamese medicinal mushrooms increase the bioavibility of curcumin and helps recover neurons in mice Alzheimer’s model.

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    Amari, N. O., Djebli, N., Huong, L. M., Ha, T. T. H., Luyen, N. D., & Bich, V. T. (2020). Neuroprotective effect of 1, 3-β-glucan-curcumin mixing (Bioglucur) on Alzheimer Disease Induced in Mice by Aluminium Toxicity. Indian Journal of Pharmaceutical Education and Research, 54(4), 1089–1097. https://doi.org/10.5530/ijper.54.4.204