Volume 55, Issue 4

Lavanya N, Sayani Bhattacharyya

pp. 930–938 · DOI: 10.5530/ijper.55.4.193 · 2021

The review provides an insight into the application of Computational Fluid Dynamics (CFD), a versatile tool for analysis of complex dynamics of air and fluid flow in pharmaceutical operations. The principle of Navier Sto…

Lu-Feng Cheng, Jin-Sen Kang, Qi Xu

pp. 939–946 · DOI: 10.5530/ijper.55.4.194 · 2021

Context: As a bridge course between basic medicine and clinical medicine, pharmacology is a compulsory course for students majoring in clinical medicine. Aim: The purpose this teaching is to establish a holistic thinking…

Hemant Gupta, Bhaveshkumar J Parmar

pp. 947–956 · DOI: 10.5530/ijper.55.4.195 · 2021

Objectives: The objective of this study to build a comprehensive model to measure the service quality of the pharmaceutical institutes in India. At the same time, the author also validates the model with two different ap…

Akshaya Srikanth Bhagavathula, Deepak Kumar Bandari, Daniela Fialova

pp. 957–965 · DOI: 10.5530/ijper.55.4.196 · 2021

Objectives: The present study aimed to evaluate the quality of pharmacotherapy (PT) lectures provided to PharmD students and to assess the teaching skills of the instructors. Materials and Methods: A cross-sectional stud…

Meenakshi Bhavesh Patel, Farhatjahan Shaikh, Vandana B. Patel, Naazneen Surti

pp. 966–978 · DOI: 10.5530/ijper.55.4.197 · 2021

Introduction: Microsponges provides a proficient drug delivery system for specific delivery in the upper gastrointestinal tract with high drug loading capability. But the formulation is affected by numerous process and d…

Juhi Desai, Rashmi Mallya

pp. 979–988 · DOI: 10.5530/ijper.55.4.198 · 2021

Background: Green beans of Coffee arabica L. Family: Rubiacea are rich source of polyphenols that prevents the oxidative damage to the skin. In this study, Liposomes were formulated as drug carrier to enhance the skin pe…

Garima Shandilya, Kirtan Tarwadi, Sachin Chavan, Jai Singh Vaghela

pp. 989–995 · DOI: 10.5530/ijper.55.4.199 · 2021

Aim: Wound is a fragile and complex injury which can be as simple as a minor cut to the deep lesions and traumatic gash. Depending on the patient’s internal and external conditions, wounds can progress backward or forwar…

Tej Pratap Singh, Farhan Jalees Ahmad, Gaurav Kumar Jain, Navneet Verma

pp. 996–1007 · DOI: 10.5530/ijper.55.4.200 · 2021

Background: Nanoemulsion-gels are nanosized droplets, and thermodynamically stable oil-in-water dispersion. Raloxifene hydrochloride a selective estrogen receptor modulator currently its more research is being laid on in…

Misbahuddin M. Rafeeq, Shahnaz Haque, Ziaullah M. Sain, Ahmad Alzamami, Norah A. Alturki, Mutaib M. Mashraqi, Youssef Saeed Alghamdi, Rashed Ahmed Alniwaider, Ayyub Patel

pp. 1008–1016 · DOI: 10.5530/ijper.55.4.201 · 2021

Background: Genetic disorders such as diabetes have severe implications on human health. Mutation or aberrant activity of different proteins are associated with diabetes. The hyperactivation of the peptidase function of …

Jemmy Christy, Shiva Shankari, Ilma Majeed, Daniel Alex Anand

pp. 1017–1027 · DOI: 10.5530/ijper.55.4.202 · 2021

Steroidal alkaloid cortistatin is a promising marine natural compound isolated from marine sponges Corticium simplex. Experimental studies and clinical evidence have shown that cortistatin and its derivatives have a cura…

Afaf S. Alwabli, Ishtiaq Qadri

pp. 1028–1036 · DOI: 10.5530/ijper.55.4.203 · 2021

Background: Non-structural protein 5 (NS5) is considered as an important protein in Dengue viruses (DENVs). It contains N-terminal methyltransferase (MTase) and C-terminal RNA-dependent RNA polymerase (RdRp) domains. NS5…

Jasleen Kaur Virdi, Ritu Kulshrestha, Amteshwar Singh Jaggi

pp. 1037–1047 · DOI: 10.5530/ijper.55.4.204 · 2021

Aim: To study the effect of 3-methyladenine and chloroquine phosphate on 3-nitropropionic acid induced Huntington’s disease-like symptoms in mice. Materials and Methods: 3-Nitropropionic acid was administered at the dose…

Promise Madu Emeka, Hairul-Islam Mohamed Ibrahim, Mohamed Aly Morsy, Ibrahim Abdulraham Alhaider, Snawar Hussian, Emad Abdelaziz Ahmed

pp. 1048–1059 · DOI: 10.5530/ijper.55.4.205 · 2021

Sulforaphane (SPN) is reported to activate the Nrf2/Keap1 complex responsible for protein and gene expression promotion of various antioxidant enzymes. The present study examined the role of Nrf2 in modulating other sign…

Beere Nagaraju, KV Anilkumar

pp. 1060–1065 · DOI: 10.5530/ijper.55.4.206 · 2021

Aim: The present study was planned to evaluate the pharmacodynamic and pharmacokinetic interactions between telmisartan and glimepiride + metformin in single and multiple dose studies using rats and rabbits. Materials an…

Mohamed Aly Morsy, Azza Ali Kamel El-Sheikh, Ahmed Ragaa Nour Ibrahim, Mahmoud El-Daly

pp. 1066–1073 · DOI: 10.5530/ijper.55.4.207 · 2021

Background: Methotrexate (MTX), a successfully used chemotherapeutic in the treatment of various malignancies and autoimmune diseases, might cause severe nephrotoxicity. Here, we aimed at investigating possible nephropro…

Sanjita Das, Irfan Khan, Shruti Dhasmana, Shivani Shrivastava, KM Renu Singh

pp. 1074–1083 · DOI: 10.5530/ijper.55.4.208 · 2021

Aim: Literature shows the traditional as well as scientific proven medicinal importance of Nyctanthes arbortristis Linn. In the it was aimed at to formulate and screen the antidiabetic, hypolipidemic and antioxidant prop…

Ayusman Swain, Aralakuppe Narayana Santhoshkannada, Duraivadivel Prabakaran, Gourav Choudhir, Hariprasad Puttaswamy

pp. 1084–1095 · DOI: 10.5530/ijper.55.4.209 · 2021

Introduction: Cyperus articulatus rhizome has been used in folk medicine by different inhabitants belonging to tropical and subtropical regions. But its metabolite profile and potential pharmacological and food applicati…

Nivetha Anbalagan, Mohanasrinivasan Vaithilingam

pp. 1096–1106 · DOI: 10.5530/ijper.55.4.210 · 2021

Context: The Novelty of the research is to formulate the probiotic product with low cost submerged fermentation for the mitigation of lactose intolerance. The utilization of substrate enhances the production of β-galacto…

Karunakaran Balaji, J Vijayakumar, Sivanesan Senthilkumar, Rajagopalan Vijayaraghavan, Viswanathan Naveenkumar

pp. 1107–1114 · DOI: 10.5530/ijper.55.4.211 · 2021

Objectives: The plant Celastrus paniculatus is used in the traditional medical practices of India to treat a plethora of diseases. Earlier research on the plant revealed several biological properties and interesting bioa…

Vinay Kumar Gupta, Asha Pathak, Chandra Veer Singh, Manoj Gahlot, Devender Pathak

pp. 1115–1124 · DOI: 10.5530/ijper.55.4.212 · 2021

Aim: The objective of the present study was to screen the anti-hyperglycaemic and anti-hyperlipidemic activities of leaf extracts (Pet-ether, Chloroform, Acetone, and Methanol) of Cassia glauca Lam. on streptozotocin-nic…