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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

In silico Investigation and Molecular Docking Study of Triazolo-thiadiazole Derivatives for Antimicrobial, Anti-inflammatory and Anti-diabetic Activity

Amol Sopanrao Dighe1,2★, Ashim Kumar Sen1★ Corresponding author

  1. 1Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat State, INDIA.
  2. 2Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, Maharashtra, INDIA.

CORRESPONDENCE

Amol Sopanrao Dighe

Assistant Professor, Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni-413736, Maharashtra, INDIA.

amoldighe143@gmail.com

Received: 04-03-2021; Revised: 18-05-2021; Accepted: 10-09-2021.

Volume 55, Issue 4 · pp. 1125–1144 · PUBLISHED 2021 · DOI: 10.5530/ijper.55.4.213

View on IJPER original site ↗

ABSTRACT

Triazolo-thiadiazole and connected fused ring in heterocyclic compounds are of highly interest in potential bioactive molecules. Triazolo-thiadiazole derivatives have lead of organic chemists due to their good biological and chemotherapeutic significance. Research in the field of anti-mycobacterium, anti-inflammatory, anti-diabetic and anti-microbial therapies are ongoing and studies are seeking. Therefore, the discovery of new effective anti-mycobacterium, anti-inflammatory, anti-diabetic and antimicrobial agents are imperative. Swiss programs are used to predict Triazolo-thiadiazole derivatives properties that are important for drug profile. Later, all of them were docked into the active sites of enzymes namely Ribosomal RNA large subunit methyltransferase (1P91), PeriplasmicOligopeptide-Binding Protein (1B05) and Protein-tyrosine phosphatase, non-receptor type 1 (1q6s), those were considered in Antidiabetic studies of triazolo-thiazazole derivative. Docking study when compared with Triazolo-thiadiazole derivatives with standard drug, derivative docking result is better. Ciprofloxacin, ibuprofen, and acarbose have been used as standard drugs for antimicrobial, anti-inflammatory and anti-diabetic activity in comparative docking studies.

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    Dighe, A. S., & Sen, A. K. (2021). In silico Investigation and Molecular Docking Study of Triazolo-thiadiazole Derivatives for Antimicrobial, Anti-inflammatory and Anti-diabetic Activity. Indian Journal of Pharmaceutical Education and Research, 55(4), 1125–1144. https://doi.org/10.5530/ijper.55.4.213