Volume 55, Issue 4

2021 · pp. 930–1223 · 28 articles

Volume: 55
Issue: 4
Published: 2021
Pages: 930–1223
Articles: 28
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Computational Fluid Dynamics-The Futuristic Innovation in Pharmaceutical Industry
Lavanya N, Sayani Bhattacharyya
pp. 930–938 · DOI: 10.5530/ijper.55.4.193 · Published 2021
The review provides an insight into the application of Computational Fluid Dynamics (CFD), a versatile tool for analysis of complex dynamics of air and fluid flow in pharmaceutical operations. The principle of Navier Sto…

Original Article

Article
Research on the Constructing the Holistic Thinking Mode and Teaching Effect of Pharmacology
Lu-Feng Cheng, Jin-Sen Kang, Qi Xu
pp. 939–946 · DOI: 10.5530/ijper.55.4.194 · Published 2021
Context: As a bridge course between basic medicine and clinical medicine, pharmacology is a compulsory course for students majoring in clinical medicine. Aim: The purpose this teaching is to establish a holistic thinking…
Article
The Measurement Model of the Pharmacy Education Service Quality: An Empirical Quest Based on Two Approaches
Hemant Gupta, Bhaveshkumar J Parmar
pp. 947–956 · DOI: 10.5530/ijper.55.4.195 · Published 2021
Objectives: The objective of this study to build a comprehensive model to measure the service quality of the pharmaceutical institutes in India. At the same time, the author also validates the model with two different ap…
Article
Quality of Pharmacotherapy Lectures and Instructor Teaching Skills of the Pharm D Program in India: A Nationwide Survey
Akshaya Srikanth Bhagavathula, Deepak Kumar Bandari, Daniela Fialova
pp. 957–965 · DOI: 10.5530/ijper.55.4.196 · Published 2021
Objectives: The present study aimed to evaluate the quality of pharmacotherapy (PT) lectures provided to PharmD students and to assess the teaching skills of the instructors. Materials and Methods: A cross-sectional stud…
Article
Application of Experiential Design for Framing Gastroretentive Microsponges of Glipizide: Screening of Critical Variables by Plackett-Burman Design and Optimization by Box-Behnken Design
Meenakshi Bhavesh Patel, Farhatjahan Shaikh, Vandana B. Patel, Naazneen Surti
pp. 966–978 · DOI: 10.5530/ijper.55.4.197 · Published 2021
Introduction: Microsponges provides a proficient drug delivery system for specific delivery in the upper gastrointestinal tract with high drug loading capability. But the formulation is affected by numerous process and d…
Article
Development of Green Coffee Beans Extract Loaded Anti-aging Liposomal Gel
Juhi Desai, Rashmi Mallya
pp. 979–988 · DOI: 10.5530/ijper.55.4.198 · Published 2021
Background: Green beans of Coffee arabica L. Family: Rubiacea are rich source of polyphenols that prevents the oxidative damage to the skin. In this study, Liposomes were formulated as drug carrier to enhance the skin pe…
Article
BioFibGel: A Green Nanotechnology Based Wound Dressing
Garima Shandilya, Kirtan Tarwadi, Sachin Chavan, Jai Singh Vaghela
pp. 989–995 · DOI: 10.5530/ijper.55.4.199 · Published 2021
Aim: Wound is a fragile and complex injury which can be as simple as a minor cut to the deep lesions and traumatic gash. Depending on the patient’s internal and external conditions, wounds can progress backward or forwar…
Article
Formulation Development and Characterization of Nanoemulsion-based Gel for Topical Application of Raloxifene Hydrochloride
Tej Pratap Singh, Farhan Jalees Ahmad, Gaurav Kumar Jain, Navneet Verma
pp. 996–1007 · DOI: 10.5530/ijper.55.4.200 · Published 2021
Background: Nanoemulsion-gels are nanosized droplets, and thermodynamically stable oil-in-water dispersion. Raloxifene hydrochloride a selective estrogen receptor modulator currently its more research is being laid on in…
Article
Sodium-glucose Cotransporter-2 Inhibitors as Modulator of Dipeptidyl Peptidase-4 in Diabetes
Misbahuddin M. Rafeeq, Shahnaz Haque, Ziaullah M. Sain, Ahmad Alzamami, Norah A. Alturki, Mutaib M. Mashraqi, Youssef Saeed Alghamdi, Rashed Ahmed Alniwaider, Ayyub Patel
pp. 1008–1016 · DOI: 10.5530/ijper.55.4.201 · Published 2021
Background: Genetic disorders such as diabetes have severe implications on human health. Mutation or aberrant activity of different proteins are associated with diabetes. The hyperactivation of the peptidase function of …
Article
Deciphering the Synergistic Mechanism of Cortistatin towards Cancer Targets Using Network Pharmacology Approach
Jemmy Christy, Shiva Shankari, Ilma Majeed, Daniel Alex Anand
pp. 1017–1027 · DOI: 10.5530/ijper.55.4.202 · Published 2021
Steroidal alkaloid cortistatin is a promising marine natural compound isolated from marine sponges Corticium simplex. Experimental studies and clinical evidence have shown that cortistatin and its derivatives have a cura…
Article
Identification of Possible Inhibitor Molecule against NS5 MTase and RdRp Protein of Dengue Virus in Saudi Arabia
Afaf S. Alwabli, Ishtiaq Qadri
pp. 1028–1036 · DOI: 10.5530/ijper.55.4.203 · Published 2021
Background: Non-structural protein 5 (NS5) is considered as an important protein in Dengue viruses (DENVs). It contains N-terminal methyltransferase (MTase) and C-terminal RNA-dependent RNA polymerase (RdRp) domains. NS5…
Article
Ameliorative Effects of 3-methyladenine and Chloroquine in 3-nitropropionic-induced Huntington’s Disease like Symptoms in Mice
Jasleen Kaur Virdi, Ritu Kulshrestha, Amteshwar Singh Jaggi
pp. 1037–1047 · DOI: 10.5530/ijper.55.4.204 · Published 2021
Aim: To study the effect of 3-methyladenine and chloroquine phosphate on 3-nitropropionic acid induced Huntington’s disease-like symptoms in mice. Materials and Methods: 3-Nitropropionic acid was administered at the dose…
Article
Attenuation of Cardiomyopathy Induced in Sub-Chronic Exposure of Acrolein by Sulforaphane via Indirect PPARy Expression Promoter
Promise Madu Emeka, Hairul-Islam Mohamed Ibrahim, Mohamed Aly Morsy, Ibrahim Abdulraham Alhaider, Snawar Hussian, Emad Abdelaziz Ahmed
pp. 1048–1059 · DOI: 10.5530/ijper.55.4.205 · Published 2021
Sulforaphane (SPN) is reported to activate the Nrf2/Keap1 complex responsible for protein and gene expression promotion of various antioxidant enzymes. The present study examined the role of Nrf2 in modulating other sign…
Article
Influence of Telmisartan on Pharmacodynamic and Pharmacokinetic Properties of Glimepiride-metformin Combination Using Rodent and Non-Rodent Models
Beere Nagaraju, KV Anilkumar
pp. 1060–1065 · DOI: 10.5530/ijper.55.4.206 · Published 2021
Aim: The present study was planned to evaluate the pharmacodynamic and pharmacokinetic interactions between telmisartan and glimepiride + metformin in single and multiple dose studies using rats and rabbits. Materials an…
Article
Protection of Hesperidin against Methotrexate-Induced Nephrotoxicity may be Mediated by Nrf2/HO-1 Pathway
Mohamed Aly Morsy, Azza Ali Kamel El-Sheikh, Ahmed Ragaa Nour Ibrahim, Mahmoud El-Daly
pp. 1066–1073 · DOI: 10.5530/ijper.55.4.207 · Published 2021
Background: Methotrexate (MTX), a successfully used chemotherapeutic in the treatment of various malignancies and autoimmune diseases, might cause severe nephrotoxicity. Here, we aimed at investigating possible nephropro…
Article
Formulation and Evaluation of the Antidiabetic, Hypolipidemic and Antioxidant Potential of the Tablets of Arbortristoside-A from the Seeds of Nyctanthes arbortristis Linn.
Sanjita Das, Irfan Khan, Shruti Dhasmana, Shivani Shrivastava, KM Renu Singh
pp. 1074–1083 · DOI: 10.5530/ijper.55.4.208 · Published 2021
Aim: Literature shows the traditional as well as scientific proven medicinal importance of Nyctanthes arbortristis Linn. In the it was aimed at to formulate and screen the antidiabetic, hypolipidemic and antioxidant prop…
Article
Phytochemical and Pharmacological Exploration of Cyperus articulatus as a Potential Source of Nutraceuticals and Drug Ingredients
Ayusman Swain, Aralakuppe Narayana Santhoshkannada, Duraivadivel Prabakaran, Gourav Choudhir, Hariprasad Puttaswamy
pp. 1084–1095 · DOI: 10.5530/ijper.55.4.209 · Published 2021
Introduction: Cyperus articulatus rhizome has been used in folk medicine by different inhabitants belonging to tropical and subtropical regions. But its metabolite profile and potential pharmacological and food applicati…
Article
An Experimental Study Using the Statistical Tool D-optimal Design for the Process Optimization to Enhance the Yield of β-galactosidase from Lactobacillus plantarum
Nivetha Anbalagan, Mohanasrinivasan Vaithilingam
pp. 1096–1106 · DOI: 10.5530/ijper.55.4.210 · Published 2021
Context: The Novelty of the research is to formulate the probiotic product with low cost submerged fermentation for the mitigation of lactose intolerance. The utilization of substrate enhances the production of β-galacto…
Article
Protective Effect of Celastrus paniculatus Seed Extract against Lead Acetate Induced Nephrotoxicity in Wistar Rats
Karunakaran Balaji, J Vijayakumar, Sivanesan Senthilkumar, Rajagopalan Vijayaraghavan, Viswanathan Naveenkumar
pp. 1107–1114 · DOI: 10.5530/ijper.55.4.211 · Published 2021
Objectives: The plant Celastrus paniculatus is used in the traditional medical practices of India to treat a plethora of diseases. Earlier research on the plant revealed several biological properties and interesting bioa…
Article
Screening of Anti-Hyperglycaemic and Anti-Hyperlipidemic Activities of Leaves Extracts of Cassia glauca Lam. on Streptozotocin-Nicotinamide Induced NIDDM Rats
Vinay Kumar Gupta, Asha Pathak, Chandra Veer Singh, Manoj Gahlot, Devender Pathak
pp. 1115–1124 · DOI: 10.5530/ijper.55.4.212 · Published 2021
Aim: The objective of the present study was to screen the anti-hyperglycaemic and anti-hyperlipidemic activities of leaf extracts (Pet-ether, Chloroform, Acetone, and Methanol) of Cassia glauca Lam. on streptozotocin-nic…
Article
In silico Investigation and Molecular Docking Study of Triazolo-thiadiazole Derivatives for Antimicrobial, Anti-inflammatory and Anti-diabetic Activity
Amol Sopanrao Dighe, Ashim Kumar Sen
pp. 1125–1144 · DOI: 10.5530/ijper.55.4.213 · Published 2021
Triazolo-thiadiazole and connected fused ring in heterocyclic compounds are of highly interest in potential bioactive molecules. Triazolo-thiadiazole derivatives have lead of organic chemists due to their good biological…
Article
Synthesis, Characterization and Antidiabetic Evaluation of Sulfonamide in Corporated with 1,3,4-Oxadiazole Derivatives
Megha Tukaram Salve, Shailaja Bhanudas Jadhav Sr
pp. 1145–1150 · DOI: 10.5530/ijper.55.4.214 · Published 2021
Aim/Background: There is an increasing prevalence of diabetes mellitus throughout the world, and new compounds are necessary to combat this. While the current available antidiabetic therapies are long-term complicated an…
Article
1,3,4-thiadiazole Attached 2, 3- disubstituted Thiazolidinones Derivatives: Synthesis and Biological Evaluation
Ashish Garg, Sweta Garg
pp. 1151–1163 · DOI: 10.5530/ijper.55.4.215 · Published 2021
Background: Thiazolidinone derivatives are the subject of prominent importance since they have been seen as valuable intermediates for the formulating/synthesize of different heterocyclic derivatives and it gives various…
Article
Application of Augmented Simplex Centroid Design for Optimization of HPLC Mobile Phase for Estimation of Curcumin and Piperine
Jahnavi Naik, Sonal Desai, Vinodkumar Ramani
pp. 1164–1172 · DOI: 10.5530/ijper.55.4.216 · Published 2021
Background: Optimization of mobile phase for high performance liquid chromatography (HPLC) is an exigent task where one factor at a time (OFAT) approach is not preferable as it is time consuming specially for multifacete…
Article
Development and Validation of Analytical Method for Quantitative Estimation of Multiple Metal Impurities in Dobutamine Hydrochloride using ICPMS Spectroscopy
Sayyad Kousr Ali, Tanmoy Mondal
pp. 1173–1182 · DOI: 10.5530/ijper.55.4.217 · Published 2021
Objectives: Primary objective of the present study is to develop and validate an accurate and linear analytical method for precise estimation of Vanadium, Cobalt, Nickel, Arsenic, Cadmium, Mercury, Thallium and Lead elem…
Article
Molecular Characterization of Genetic Diversity of Plasmodium falciparum Associated with Imported Cases of Malaria in Southeastern Region of Saudi Arabia
Lorina I Badger-Emeka, Abdulrahman A Al Sultan, Ahlam A Al Qatari, Abdullatif Sami Al Rashed, Ahmed Al Sayyah
pp. 1183–1196 · DOI: 10.5530/ijper.55.4.218 · Published 2021
Growing global international travel has reflected significantly on the number of imported cases of malaria into non endemic regions of the world inclusive of Saudi Arabia were transmission of the disease is significantly…
Article
Evaluation of iceA1 Gene Expression of Helicobacter pylori Risk Factor of Gastric Cancer in Transgenic Brinjal
Mohammad Javad Mehran, Basaralu Yadurappa Sathish Kumar, Nanjundappa Haraprasad, Rambod Barzigar, Bashasab Fakrudin, Sayan Paul
pp. 1197–1206 · DOI: 10.5530/ijper.55.4.219 · Published 2021
Background: The advancement of plant biotechnology improved crop production by revolutionizing plant science. Humans were commonly infected by Helicobacter pylori, and it was closely linked to stomach ulcers and cancer. …
Article
Implementation of Quality by Design (QbD) Approach in Development of QCT-SMEDDS with Combination of AgNPs for Diabetic Foot Ulcer Management
Reena Badhwar, Ruchi Singh, Tinku, Harvinder Popli
pp. 1207–1223 · DOI: 10.5530/ijper.55.4.220 · Published 2021
Introduction: Quercetin (QCT) is a flavonoid with antioxidant, potential free radical scavenger, and strong anti-inflammatory activities. These properties of QCT promote wound healing process. Objectives: The present wor…