Volume 56, Issue 1

2022 · pp. 1–310 · 35 articles

Volume: 56
Issue: 1
Published: 2022
Pages: 1–310
Articles: 35
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Original Article Research Article

In this issue

Original Article

Article
Development of Magnetic Nanoparticles and Encapsulation Methods – An Overview
Venkata Satya Madhulatha, E Susithra, Raghavendra Kumar Gunda
pp. 1–8 · DOI: 10.5530/ijper.56.1.1 · Published 2022
Nanotechnology is a versatile evolving field today. The importance of nanoparticles reaches high in diagnostics, medicine, or pharmaceuticals for drug delivery. Among all the different nanoparticles, Magnetic nanoparticl…
Article
Telepharmacy Knowledge, Perceptions, and Readiness among Future Malaysian Pharmacists Amid the COVID-19 Pandemic
Mohamed Hassan Elnaem, Muhammad Eid Akkawi, Abdul Kareem Al-Shami, Ramadan Elkalmi
pp. 9–16 · DOI: 10.5530/ijper.56.1.2 · Published 2022
Background: Telepharmacy is a relatively recent advancement in healthcare services that enables providing high-quality pharmacy services to rural and remote areas. It gained increased attention during the COVID19 pandemi…
Article
Perspectives of Pharmacy University Students on Scientific Research in Comparison to Students from Other Health Science Disciplines
Syed Mohammed Basheeruddin Asdaq, Mohammed Kanan Alshammari, Bassam Mohammed Alanazi, Ahmed Naif Alshammari, Mishal Abdulrahman Alrumaih, Mohd. Imran, Abdulhakeem S Alamri, Majid Alhomrani, Walaa F. Alsanie, Nagaraja Sreeharsha
pp. 17–23 · DOI: 10.5530/ijper.56.1.3 · Published 2022
Background: The value of scientific research should be instilled in students from the very beginning of their university education, to foster a creative attitude in the next generation. It is critical to promote a resear…
Article
New Approach of Dipterocarpus alatus Oil as a Permeation Enhancer in Ibuprofen Gel
Supawadee Daodee, Orawan Monthakantirat, Yaowared Chulikhit
pp. 24–31 · DOI: 10.5530/ijper.56.1.4 · Published 2022
Background: Yang-na tree has a scientific name as Dipterocapus alatus Roxb. Ex G.Don in family Dipterocarpaceae. Many parts of this tree can be used especially for D. alatus oil. Objectives: To develop basic formula of i…
Article
Forced Degradation of Flibanserin Bulk Drug: Development and Validation of Stability Indicating RP-HPLC Method
Yik-Ling Chew, Hon-Kent Lee, Mei-Ann Khor, Kai-Bin Liew, Bontha Venkata Subrahmanya Lokesh, Gabriel Akyirem Akowuah
pp. 32–42 · DOI: 10.5530/ijper.56.1.5 · Published 2022
Background: Flibanserin had been approved as the first drug by United State Food and Drug Administration (USFDA) for the treatment of female sexual interest/arousal disorder of any severity. However, the stability of thi…
Article
Formulation and Evaluation of Film Forming Solution of Diphenhydramine Hydrochloride for Transdermal Delivery
Akhil Baby, Hagalavadi Nanjappa Shivakumar, Prajila Alayadan
pp. 43–49 · DOI: 10.5530/ijper.56.1.6 · Published 2022
Aim: The present work intends to formulate and evaluate film forming solution of diphenhydramine. Materials and Methods: Film forming solutions (FFS) for transdermal delivery of Diphenhydramine HCl were prepared using di…
Article
Formulation of Mupirocin Adsorbed Silver Nanoparticle with Antibiofilm Agents for Enhancing Antibacterial Activity
Selliamman Ravi Mahi Priya, Rajandurai Baby Roselin, Arjunan Karuppiah, Veintramuthu Sankar
pp. 50–57 · DOI: 10.5530/ijper.56.1.7 · Published 2022
Introduction: Biofilm is a complex structure of microbiome having different bacterial colonies or single type of cells in a group, adhere to the surface to produce infections. Nanoparticles (NPs) are widely used in diffe…
Article
Effect of Formulation Variables on Fabrication of Risperidone Loaded Nanoparticles for Sustained Drug Delivery
Dipti Gohil, Nirmal Shah, Rajesh A. Maheshwari
pp. 58–64 · DOI: 10.5530/ijper.56.1.8 · Published 2022
Aim/ Background:Risperidone, an atypical antipsychotic agent, is used in the treatment of psychotic disorders due to its lower Extra Pyramidal side Effects (EPS) than conventional antipsychotics. Materials and Methods: T…
Article
Development of Tapentadol Hydrochloride Loaded Proniosomal Gel using Main Effects Screening Design and in silico Verification using Parameter Sensitivity Analysis
Sangeetha G, Swamivel Manickam M, Sanil Kumar P, Chandramouli R
pp. 65–76 · DOI: 10.5530/ijper.56.1.9 · Published 2022
Aim: Tapentadol Hydrochloride is a centrally acting opioid analgesic of biopharmaceutical classification system class I drug. Oral administration of tapentadol hydrochloride undergoes extensive first-pass metabolism lead…
Article
Nanostructured Lipid Carrier: A Potential System for Enhanced Oral Bioavailability of Felodipine
Archana Sidagouda Patil, Vinayak Jaknoor, Anand Panchakshari Gadad, Rajashree Shashidhar Masareddy, Panchaxari Mallappa Danadagi, Udaykumar Bolmal
pp. 77–85 · DOI: 10.5530/ijper.56.1.10 · Published 2022
Background: Felodipine is BCS class II drug with poor and variable bioavailability due to its insolubility in water (19mg/L) and extensive metabolism in liver and gut. Thus, in the study Nanostructured lipid carriers (NL…
Article
Fabrication and Evaluation of Gemcitabine-loaded Alginate Microspheres: A Potential Approach for Treatment of Various Carcinomas
Maruf Hossain, Shayeri Chatterjee, Hiranmoy Paria, Soumya Ganguly
pp. 86–93 · DOI: 10.5530/ijper.56.1.11 · Published 2022
Aim/background: Microspheres are spherical particles, having a core, having a particle size of 1μm to 1000μm. They are advantageous as compared to conventional dosage forms of drugs, in parameters like sustainability and…
Article
Development and Evaluation of Nanosuspension Incorporated in situ gel of Brimonidine Tartarate for Ocular Drug Delivery
Viresh Hanagandi, Archana Sidagouda Patil, Rajashree Shashidhar Masareddy, Panchaxari Mallappa Dandagi, Udaykumar Baburao Bolmal
pp. 94–102 · DOI: 10.5530/ijper.56.1.12 · Published 2022
Objectives: The goal of the study was to develop, optimize and in vitro-ex vivo investigation of Brimonidine tartrate nanosuspension incorporated in situ gel formulation to differentiate with marketed (formulation) eye d…
Article
Formulation and Evaluation of Natamycin Solid Dispersion Incorporated Ophthalmic Films
Lavanya Bhandari, Archana S Patil, Udaykumar Bolmal, Rajashree Masareddy, Panchaxari Dandagi
pp. 103–111 · DOI: 10.5530/ijper.56.1.13 · Published 2022
Background: The aim of this study was to enhance the solubility of Natamycin, an antifungal agent used in fungal keratitis, through solid dispersion incorporated ophthalmic films with the purpose to avoid frequent dosing…
Article
Preparation and Characterization of Transdermal Therapeutic System Containing Simvastatin: A Statistical Study
Santosh Kumar Mishra, Rahul Kumar, Purushottam Ramchandra Patil, Rishiksh Gupta, Alok Mahor, Peeyush Bhardwaj
pp. 112–120 · DOI: 10.5530/ijper.56.1.14 · Published 2022
Introduction: The purpose of the present study was to design, develop, and characterize the transdermal patches containing Simvastatin for the management of blood lipid levels. Materials and Methods: Transdermal patches …
Article
Solid Dispersion of Lumefantrine Using Soluplus® by Solvent Evaporation Method: Formulation, Characterization and in-vitro Antimalarial Screening
Pranita Sunil Kanojiya, Yogita Charde, Jasmine Gev Avari, Rita Naresh Wadetwar
pp. 121–132 · DOI: 10.5530/ijper.56.1.15 · Published 2022
Objectives: Lumefantrine (LUM) is an antimalarial drug having poor aqueous solubility. The objective was to formulate the solid dispersion of LUM and improve the solubility and dissolution rate. Materials and Methods: So…
Article
Preparation and in-vitro / in-vivo Characterization of Transdermal Amphiphilogel Loaded with Biodegradable Polymeric Submicron Carriers of Meloxicam for Treatment of Inflammation
Dilesh Jagdish Singhavi, Pramod Yeole, Shagufta Khan
pp. 133–143 · DOI: 10.5530/ijper.56.1.16 · Published 2022
Aim: The main purpose for this study was to develop and evaluate amphiphilogels loaded with meloxicam-submicron particles considering the benefits of the transdermal route of administration of anti-inflammatory drugs (no…
Article
Topical Delivery of Methocarbamol Loaded Nanoemulgel - in vitro Characterization
Abimanyu Sugumaran, Vishali Mathialagan
pp. 144–152 · DOI: 10.5530/ijper.56.1.17 · Published 2022
Background: Methocarbamol is used as skeletal muscle relaxant. Nanoemulgel is currently being developed as a transdermal drug delivery technology because to its nanosized droplets, which provide superior effectiveness wi…
Article
Solid Dispersion of Artemether in Fast Disintegrating Tablet to Enhance Dissolution Rate and Oral Bioavailability
Pranita Sunil Kanojiya, Yogita Manohar Charde, Rita Naresh Wadetwar
pp. 153–165 · DOI: 10.5530/ijper.56.1.18 · Published 2022
Objectives: Artemether (ART), an antimalarial drug, have poor solubility and low bioavailability. Therefore, solid dispersion of the drug was formulated using Soluplus (SOL) and was incorporated in the fast disintegratin…
Article
Evaluation of Cell Death Potential of Lepidium sativum Seed Extracts in MCF-7 Cells and Molecular Docking-based Correlation of Identified Bioactive Components with Human Caspase-6 Protein
Rajasekaran R, Suresh P.K
pp. 166–174 · DOI: 10.5530/ijper.56.1.19 · Published 2022
Aim and Background:The methanolic extract of Lepidium sativum L. was known for its free radical scavenging potential and anticancer properties. The aim was to perform a comparative investigation of the cytotoxic and cell…
Article
Effect of Ocimum sanctum in Sodium fluoride (NaF) induced Fluorosis in Rats: A Study with Respect to Antioxidant Enzymes and Fluorosis Markers
Kondeti Ramudu Shanmugam, Bhasha Shanmugam, Mavulapati Siva, Sahukari Ravi, Kesireddy Sathyavelu Reddy
pp. 175–183 · DOI: 10.5530/ijper.56.1.20 · Published 2022
Introduction: Fluoride contamination was observed in groundwater’s of India, Pakistan, China, Indonesia and several other countries. In India the states like Andhra Pradesh, Telangana, Rajasthan, Haryana etc are contamin…
Article
In vivo wound Healing Activity of Ointment based Formulation for Prunus amygdalus (Batsch.) on Rats
Diksha Singh, Kashmira J Gohil, Vikash Sharma, Shiv Shankar Shukla
pp. 184–190 · DOI: 10.5530/ijper.56.1.21 · Published 2022
Objectives: The present study is to investigate the wound healing activity of F1-PAO and F2-PAE ointment formulations based on Prunus amygdalus oil and extract respectively. Materials and Methods: The ethanolic and n- he…
Article
Evaluation of Hepatoprotective Potential of Stem Bark of Neolamarckia cadamba against Chloroform and Over dose of Iron Dextran Induced Hepatotoxicity in Experimental Swiss Albino Mice
Saumya Das, Richa Shakya, Avijit Mazumder, Komal Bhati, Manas Kumar Das
pp. 191–198 · DOI: 10.5530/ijper.56.1.22 · Published 2022
Background: In general, use of herbal medicines are considered as the backbone in traditional system of medicines as it has been used for food, flavoring agents and in the form of medicines. Keeping in knowledge the incr…
Article
In silico and Molecular Docking Studies of Black Pepper Phyto-constituents against EmrD Efflux Pump of E. coli
Prerana Dongre, Rajendra Bhambar, Satish Polshettiwar
pp. 199–206 · DOI: 10.5530/ijper.56.1.23 · Published 2022
Multidrug resistance (MDR) bacterial infection is the next pandemic waiting behind the COVID-19 with annual mortality rate 700000 worldwide. Among the MDR bacteria, Escherichia coli, Staphylococcus aureus, Klebsiella pne…
Article
Antioxidant and Antidiabetic Activity of Berberis lycium : The Possibilities of TLC-MS Bioautography and in silico Study
Harjeet Singh, Nardev Singh
pp. 207–214 · DOI: 10.5530/ijper.56.1.24 · Published 2022
Background: Since ancient times, the traditional system of medicine has been practiced and developed an array of defense strategies to manage various ailments. About 60-80 percentof people from different parts of the wor…
Article
Hydroxychloroquine Metabolites – An Exploratory Computational Study
Mohammed Monirul Islam, Purna Sivarama Singh, Sayeed Rushd
pp. 215–223 · DOI: 10.5530/ijper.56.1.25 · Published 2022
Background: HCQ has been found to provide the immunomodulation that helps to abate the possible cytokine storm response caused by the SARS COVID-19 virus and subsequent failures of major organs. It is also being used his…
Article
Smart Spectrophotometric Method Development for Simultaneous Estimation of Antidiabetic Drugs in Formulations
Mahesh Attimarad, Katharigatta Narayanaswamy Venugopala, Sheeba Shafi, Abdulmalek Ahmed Balgoname, Abdulrahman Ibrahim Altaysan
pp. 224–231 · DOI: 10.5530/ijper.56.1.26 · Published 2022
Background: An anti-diabetic formulation consisting of vildagliptin and remogliflozin was prescribed for better glycemic control. In the present study a simple, rapid derivative spectrophotometric methods were evolved to…
Article
Development of Validated Stability Indicating Method for Estimation of Vandetanib and Characterization of its Degradants by LC-ESI-MS
Vikrant Liladhar Salode, Madhuri Deorao Game, Gouri Vikrant Salode, Sonali Suresh Gadge
pp. 232–239 · DOI: 10.5530/ijper.56.1.27 · Published 2022
Aim: In the current study, stability indicating high performance liquid chromatography method (RP-HPLC) was developed and validated for the determination of Vandetanib, also its major degradants were identified and chara…
Article
HPLC Method Development and Validation for the Quantification of Related Impurities in Testosterone Cypionate Active Pharmaceutical Ingredient
Amber Bharti, Ravindra Motiram Kumbhare, Christine Jeyaseelan
pp. 240–246 · DOI: 10.5530/ijper.56.1.28 · Published 2022
Aim: The purpose of this research study, is to develop and validate a reverse phase HPLC test method for detecting relevant impurities in Testosterone cypionate (TCY). Materials and Methods: The chromatographic system fo…
Article
Development and Validation of a Precise RP- HPLC Method to Determine Gentiopicroside Content in Cultures of Gentiana kurroo Royle
Mariadoss Alphonse, Rajasekaran Chandrasekaran, Michael Pillay, Devanand P Fulzele, Siva Ramamoorthy, Kalaivani Thiyagarajan
pp. 264–271 · DOI: 10.5530/ijper.56.1.31 · Published 2022
Background: Gentipicroside (GPD) is a major bioactive seco-iridoid glycoside in the methanolic extracts of roots and rhizomes of Gentiana kurroo Royle. GPD has antiinflammatory, antidiabetic, analgesic, antinociceptive, …
Article
Spectroscopic Substantiation for the Identification of Degradants by Q-TOF Micromass (ESI-MS) in Bisoprolol Fumarate with an Inventive Validation Approach for Stability Indicating HPLC Method
Swati Pandey, Ravindra Pandey, Shiv Shankar Shukla
pp. 272–280 · DOI: 10.5530/ijper.56.1.32 · Published 2022
Background: Stability studies, stress testing of drug substances and finished drug product is obligatory due to the guidelines by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals …
Article
Optimization of a Validated UV-Spectrophotometric Methodology for Assessment of Apigenin in Bulk Powder
Priya Shetti, Sunil S. Jalalpure
pp. 281–286 · DOI: 10.5530/ijper.56.1.33 · Published 2022
Introduction: Apigenin (4,5,7 Trihydroxyflavone) is a natural compound of flavonoids class, which is found in various plant constituents. Since primitive years, Apigenin has been used as a traditional medicine, because i…
Article
Establishment of a Rapid and Highly Sensitive Reverse-phase High-performance Liquid Chromatography Based Analytical Assay Method for Duvelisib
Dipali Sonawane, Amit Kumar Sahu, Tarang Jadav, Pinaki Sengupta
pp. 287–295 · DOI: 10.5530/ijper.56.1.34 · Published 2022
Background: Duvelisib is an antineoplastic agent that received global approval from the United States Food and Drug Administration in 2018. An extensive literature search revealed that analytical method for the quantific…
Article
Knowledge and Attitude of Taif University Students on Stem Cell Banking
Majid Alhomrani, Abdulhakeem S. Alamri, Walaa F. Alsanie, Ashwag E. Alrobiey, Raghad M. Asiri, Shahad M. Alaseri, Basmah K. Alghamdi, Sara A. Almalki, Osama Abdulaziz, Syed Mohammed Basheeruddin Asdaq, Nagaraja Sreeharsha
pp. 296–301 · DOI: 10.5530/ijper.56.1.35 · Published 2022
Background and Objectives: The awareness of university students is pivotal to the adaptation of new therapeutic technologies in combating illness and disorders. Stem cells are unique and effective in treating several pat…
Article
Sun Protection Factor Activity of Black Glutinous Rice Emulgel Extract (Oryza sativa var glutinosa)
Farhamzah Farhamzah, Anggun Hari Kusumawati, Maulana Yusuf Alkandahri, Himyatul Hidayah, Dani Sujana, Neni Sri Gunarti, Nia Yuniarsih, Sukma Dewi Apriana, Lilis Setianingsih Agustina
pp. 302–310 · DOI: 10.5530/ijper.56.1.36 · Published 2022
Background: Recently, emulgel has emerged as a potential hydrophobic drug delivery method. Therefore, this study aims to evaluate the phytochemical content of Oryza sativa extract and develop an emulgel formulation using…

Research Article

Article
Chemometric Assisted Spectrophotometric Method Development for Evaluation of Torsemide and Eplerenone in their Combined Tablet Dosage Forms
Madhuri A, Dipti Patel
pp. 255–263 · DOI: 10.5530/ijper.56.1.30 · Published 2022
Aim: In a present work two drugs Torsemide and Eplerenone were estimated from their combined tablet dosage forms by applying chemometric assisted spectrophotometric method. Methods:The methods are based on chemometrics a…