jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Preparation and in-vitro / in-vivo Characterization of Transdermal Amphiphilogel Loaded with Biodegradable Polymeric Submicron Carriers of Meloxicam for Treatment of Inflammation

Dilesh Jagdish Singhavi1★, Pramod Yeole2, Shagufta Khan1★ Corresponding author

  1. 1Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, INDIA.
  2. 2Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, INDIA.

CORRESPONDENCE

Dilesh Jagdish Singhavi

Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, INDIA.

dileshsinghavi@rediffmail.com

Received: 11-03-2021; Revised: 25-05-2021; Accepted: 10-09-2021.

Volume 56, Issue 1 · pp. 133–143 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.1.16

View on IJPER original site ↗

ABSTRACT

Aim: The main purpose for this study was to develop and evaluate amphiphilogels loaded with meloxicam-submicron particles considering the benefits of the transdermal route of administration of anti-inflammatory drugs (nonsteroidal). Materials and Methods: Glyceryl monostearate (7%, 9% and 11% w/w) and sorbiton monostearate (span 60; 21%, 23% and 25% w/w) amphiphilogels containing meloxicam-submicron particles equivalent to 0.5% w/w drug were formulated. Then these were evaluated through rheological, in-vitro permeation, in-vitro release, pharmacokinetics, pharmacodynamics and skin irritation studies. The rodents were chosen as subjects to conduct the pharmacokinetics study of meloxicam via oral administration and transdermally as solutions and gels, respectively. Results: It was observed that the Cmax value of drug obtained from meloxicam solution and a marketable piroxicam gel formulation were radically lower than that obtained from an amphiphilogel (FM4, containing 7% w/w glyceryl monostearate). It was also observed that when applied transdermally, the bioavailability of meloxicam from FM4 was higher (n = 3, p< 0.001) than 2.5 times the bioavailability of meloxicam from a solution which was orally administered. The anti-inflammatory property of FM4 was comparatively much greater than the commercially available formulations in carrageenaninduced edema in rat’s paw. Conclusion: It can be concluded that the amphiphilogels loaded with meloxicam-submicron particles was found to be a safe and efficient drug delivery system for enhanced transdermal delivery of meloxicam.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Singhavi, D. J., Yeole, P., & Khan, S. (2022). Preparation and in-vitro / in-vivo Characterization of Transdermal Amphiphilogel Loaded with Biodegradable Polymeric Submicron Carriers of Meloxicam for Treatment of Inflammation. Indian Journal of Pharmaceutical Education and Research, 56(1), 133–143. https://doi.org/10.5530/ijper.56.1.16