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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

The Neuroprotective Effects of Memantine, and Curcumin after Cerebral Ischemia-reperfusion Injury in Elderly Rats

Murat Cabalar1★, Serdar Altınay2, Funda Yildirim3, Duygu Sultan Celik4, Suat Hayri Kucuk5, Cihan Isler6, Nilgun Isiksacan7, Arsida Bajrami1, Ahmet Gulcubuk3★ Corresponding author

  1. 1Department of Neurology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, TURKEY.
  2. 2Department of Pathology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, TURKEY.
  3. 3Department of Pathology, Faculty of Veterinary Medicine, Istanbul University, TURKEY.
  4. 4Department of Animal Center, Bagcilar Training and Research Hospital, Istanbul, TURKEY.
  5. 5Department of Biochemistry, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul, TURKEY.
  6. 6Department of Neurosurgery, Faculty of Medicine Cerrahpasa, Istanbul University, Istanbul, TURKEY.
  7. 7Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, TURKEY.

CORRESPONDENCE

Murat Cabalar

Department of Neurology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, TURKEY.

mcabalar@gmail.com

Received: 05-07-2021; Revised: 12-12-2021; Accepted: 09-03-2022.

Volume 56, Issue 3 · pp. 748–755 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.3.124

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ABSTRACT

Background: Some researches reveal that pharmacologic and phytotherapeutic agents have benefits on neurological disorders associated with the effects of reactive oxygen species. Aim: The purpose of this research was to evaluate the protective effects of curcumin and memantine in a cerebral ischemia/reperfusion model in rats. Materials and Methods: This experimental study was conducted at the Bagcilar Training and Research Hospital, Istanbul, Turkey. Rats were separated into five experimental groups (n=8) as follows: Curcumin (Group I), Memantine (Group II), Curcumin+Memantine (Group III), ischemia (Group IV), and sham (Group V). Cerebral ischemia was performed surgically with bilateral common carotid artery occlusion for 30 min, followed by reperfusion for 72 hr. Tissue and serum samples were collected and assessed for tumor necrosis factor-α, interleukin-6, lactate dehydrogenase, catalase, glutathione peroxidase, xanthine dehydrogenase, superoxide dismutase, and malondialdehyde levels. Further, in tissue samples, both neuronal loss and caspase-3 levels were determined. Results: Serum and tissue levels of interleukin-6, tumor necrosis factor-α, malondialdehyde, and lactate dehydrogenase were found significantly lower in the Group I, II, and III compared to Group IV (p<0.001). Glutathione peroxidase, superoxide dismutase, and catalase levels in Group I, II, and III were significantly higher than those of Group IV (p<0.001). Conclusion: Curcumin, Memantine, and Curcumin+Memantine treatment were found to be efficacious in decreasing oxidative damage in cerebral ischemia but failed to prevent tissue damage.

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    Cabalar, M., Altınay, S., Yildirim, F., Celik, D. S., Kucuk, S. H., Isler, C., Isiksacan, N., Bajrami, A., & Gulcubuk, A. (2022). The Neuroprotective Effects of Memantine, and Curcumin after Cerebral Ischemia-reperfusion Injury in Elderly Rats. Indian Journal of Pharmaceutical Education and Research, 56(3), 748–755. https://doi.org/10.5530/ijper.56.3.124