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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Anti-diabetic Effect of Sprouted Trigonella foenumgraecum L. Seed Solid Dosage Form in Low-dose Streptozotocin Induced Diabetic Rats

Ashwini Kumar Mishra1, Pravat Kumar Sahoo1, Ganesh Lal2, Meenakshi Bajpai2, Hitesh Kumar Dewangan3

  1. 1Department of Pharmaceutics, Delhi Institute of Pharmaceutical Science and Research, DPSR University, Pushp Vihar, Sec-3, New Delhi, INDIA.
  2. 2Institute of Pharmaceutical Research (IPR), GLA University, NH-2 Mathura Delhi Road, Mathura, Uttar Pradesh, INDIA.
  3. 3University Institute of Pharma Sciences (UIPS), Chandigarh University, NH-95, Chandigarh Ludhiana Highway, Mohali, Punjab, INDIA.

CORRESPONDENCE

hiteshdewangan.hd@gmail.com

Received: 10-10-2021; Revised: 08-04-2022; Accepted: 19-07-2022.

Volume 56, Issue 4 · pp. 1156–1163 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.4.197

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ABSTRACT

Background: Trigonella foenum-graecum L (Fenugreek) is an annual herb, mainly cultivated for its seed as well as for its sprouts. Pharmacological investigations reported anti-bacterial, anti-diabetic, anti-cancer, anti-diarrheal, anti-hypercholesteremic, and antiinflammatory activities of Trigonella foenum-graecum L. Aim: The purpose of this study was to accentuate on formulation of granules and investigate the effect of germinated Trigonella foenum-graecum L. (TFG) granules in Diabetes mellitus (DM) rats induced by streptozotocin as fenugreek retains hypoglycemic property. Materials and Methods: Granules of germinated TFG powder were arranged by means of several excipients comprising diverse amounts of super disintegrants by (wet) granulation method and proceed for the solid dosage form evaluation. Further, in-vivo study was performed in STZ induced DM Wister rats for four weeks. TFG granules 1600mg/kg and Glibenclamide 0.45 mg/kg (as a positive control for comparison) were orally administrated and evaluate the diabetics in rats. Results: All evaluation parameter are correct: as in standard tablet. The STZ (Streptozotocin) induced rats the treatment with the Drug (Glibenclamide) and TFG granules significantly lowered the blood plasma glucose levels by 36% (mean ± SD glucose 120 ± 0.6 mg/dL (p < 0.001)) and 38% (mean ± SD glucose 114 ± 0.4 mg/dL; p < 0.001) respectively after 4 weeks of treatment when compared to T2DM (Type 2 Diabetes mellitus) rats. Conclusion: Experimental studies had shown that bioactive compounds found in Trigonella Foenum graceum herb have potential to cure diabetes especially due to the presence of unique chemical constituent including trigonelline, galactomannan and amino acid 4-hydroxy isoleucine. These findings suggested that TFG granules may be an alternative medicine for the management of DM.

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    Mishra, A. K., Sahoo, P. K., Lal, G., Bajpai, M., & Dewangan, H. K. (2022). Anti-diabetic Effect of Sprouted Trigonella foenumgraecum L. Seed Solid Dosage Form in Low-dose Streptozotocin Induced Diabetic Rats. Indian Journal of Pharmaceutical Education and Research, 56(4), 1156–1163. https://doi.org/10.5530/ijper.56.4.197