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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Indian Journal of Pharmaceutical Education and Research volume 56, issue 4 cover
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Cover: Indian Journal of Pharmaceutical Education and Research

Indian Journal of Pharmaceutical Education and Research

Volume 56, Issue 4

2022 · pp. 907–1252 · 37 articles

Volume
56
Issue
4
Published
2022
Pages
907–1252
Articles
37
Sections
2
ISSN
Online - 0019-5464
Journal
IJPER
Review ArticleOriginal Article

In this issue

Review Article

  1. Review

    Professional Master of Pharmacy Education in China

    Yanli Liu, Hanhan Li, Yuyao Pei, Yong Wang, Changqing Yang, Tao Lu

    pp. 907–916 · DOI: 10.5530/ijper.56.4.172 · Published 2022

    Background: The Professional Master of Pharmacy (M. Pharm.) education program in China has undergone 10 years of development and has rapidly achieved great progress. The aim of this study was to summarize and introduce t…

  2. Review

    Human Follicular Fluid, Clinical Use of Proteomics Analysis in Identification of Infertility

    Nidhi Gairola, Mahamedha Deorari, Vikash Jakhmola, Reema Sircar, Havagiray R Chitme

    pp. 917–923 · DOI: 10.5530/ijper.56.4.173 · Published 2022

    Introduction: In present situation infertility is one of the chief problem for reproductive couples due to multiple factors including lifestyle. Infertility is thought to be caused by both male and female factors in 27 p…

  3. Review

    Recent Advances and Appropriate Use of Niosomes for the Treatment of Skin Cancer

    Pottathil Shinu, Anroop B Nair, Beena Kumari, Shery Jacob, Manish Kumar, Abhishek Tiwari, Varsha Tiwari, Katharigatta N Venugopala, Mahesh Attimarad, Sreeharsha Nagaraja

    pp. 924–937 · DOI: 10.5530/ijper.56.4.170 · Published 2022

    Both melanoma and non-melanoma are the most common types of skin cancers affecting various populations across the globe. Skin malignancy is more prevalent among Caucasian populations. Non-melanoma types of skin cancers a…

  4. Review

    Animal Models Alternatives: Desideratum during COVID-19 Pandemic

    Shaweta Sharma, Akhil Sharma, Aftab Alam, Utsav Gupta

    pp. 938–949 · DOI: 10.5530/ijper.56.4.174 · Published 2022

    Aim: The present work aimed at the utilization of alternative animal models in research. Background: Animal models from a long time played an important role in drug and vaccine development. However, due to the limitation…

  5. Review

    Indian Pharmaceutical Product Protection by Utilizing Intellectual Property Rights

    Pasupuleti Dheeraj Krishna, Deeksha Kethareshwara Sujatha, Balamuralidhara Veeranna

    pp. 950–958 · DOI: 10.5530/ijper.56.4.175 · Published 2022

    Background: Intellectual property rights (IPR) are described as concepts, creations, especially artistic endeavors around which the community is ready to confer the position of ownership. There are various sorts of intel…

Original Article

  1. Article

    Effects of Online Teaching Model of “Super Star Learning System and QQ Group” on Learning Enthusiasm and Academic Performance

    Bowen Li, Wentao Yu, Jianming Jiang, Yixin Zhang, Jingshan Zhao

    pp. 959–967 · DOI: 10.5530/ijper.56.4.176 · Published 2022

    Background: Online teaching based on multiple platforms has become an important and respected teaching method. Aim: We aimed to investigate effect of “Super Star Learning System and QQ Group” online teaching model on lea…

  2. Article

    Team Based Learning Experience from a College of Pharmaceutical Sciences in United Arab Emirates

    Padma GM Rao, Syed Arman Rabbani

    pp. 968–975 · DOI: 10.5530/ijper.56.4.177 · Published 2022

    Introduction: Team-Based Learning (TBL) is an active-learning methodology that has been successfully employed in various health schools’ curricula. This study assessed the perception of pharmacy students studying in a Co…

  3. Article

    Inhibition of Escherichia coli Induced Bacterial Meningitis by Ansamycin Loaded Polymeric Nanoparticles

    Li Wang, Feng Pan, Jun Geng

    pp. 976–983 · DOI: 10.5530/ijper.56.4.178 · Published 2022

    Background: Bacterial meningitis is a serious medical disorder that should be treated as soon as possible. Aim: The effect of ansamycin as a nanoformulation on Escherichia coliinduced meningitis was investigated. Materia…

  4. Article

    Design, Optimization, in vitro and in vivo Evaluation of Flurbiprofen Loaded Solid Lipid Nanoparticles (SLNs) Topical Gel

    Keerthana K, Sandeep DS

    pp. 984–993 · DOI: 10.5530/ijper.56.4.179 · Published 2022

    Background: The aim of present study was to carry out the formulation design and evaluation of Solid Lipid Nanoparticles (SLNs) loaded topical gel of Flurbiprofen. Materials and Methods: Flurbiprofen solid lipid nanopart…

  5. Article

    Statistically 2 Level Factorial by Design Expert: In-vitro Design and Formulation of Levitiracetam Extended Release Tablets

    Challa Taraka Ramarao, Somireddy Madhuri

    pp. 994–1002 · DOI: 10.5530/ijper.56.4.180 · Published 2022

    Background: Levitiracetam is an antiepileptic medication that falls into the BCS Class I drug classification. It is used to treat specific types of seizures in adults and children with epilepsy because of its high solubi…

  6. Article

    Development and Characterization of Paliperidone Loaded Nanostructured Lipid Carrier

    Sanat Kumar Dash, Chinam Niranjan Patra, Sasmita Kumari Acharjya, Goutam Kumar Jena, Kahnu Charan Panigrahi, Nandika Khirod Kumar, Partha Sarathi Das

    pp. 1003–1012 · DOI: 10.5530/ijper.56.4.181 · Published 2022

    Background: Paliperidone is indicated for the treatment of schizophrenia. It has an absolute oral bioavailability of about 28% as it is poorly soluble in water and also undergoes hepatic first-pass metabolism. Objectives…

  7. Article

    Quality by Design: Optimization of Letrozole Solid Lipid Nanoparticle for Breast Cancer

    Sowmya Priyadarsini, Swaroop Rameshwarji Lahoti

    pp. 1013–1024 · DOI: 10.5530/ijper.56.4.182 · Published 2022

    Aim: Hormone responsive breast cancer is the most prevalent cancer worldwide. Letrozole is a third-generation aromatase inhibitor widely used for the treatment of advanced breast cancer. The primary objective of the pres…

  8. Article

    Dual-pulse Release System of Atenolol: Preparation and in-vitro Characterization

    Sonam Sanjayrao Kunjekar, Dilesh Jagdish Singhavi, Tejaswini Balkrishna Parshuramkar, Shagufta Khan

    pp. 1025–1030 · DOI: 10.5530/ijper.56.4.183 · Published 2022

    Aim: Hypertension exhibits a circadian rhythm and drugs need to be released at the time when the blood pressure is elevated most. This elevation is pronounced at 7 pm and at 4 am. Atenolol is an anti-hypertensive drug wi…

  9. Article

    Essential Oils Enriched Self-nano-emulsifying Systems for Effective Oral Delivery of Zaleplon for Improvement of Insomnia Treatment

    Hadel A. Abo El-Enin, Amany Salah Khalifa

    pp. 1031–1043 · DOI: 10.5530/ijper.56.4.184 · Published 2022

    Background: Insomnia is usually associated with mental and physical daytime impairment. Zaleplon (Zp) is indicated in insomnia management but its limited aqueous solubility led to its low bioavailability (BAV) ~30%. Self…

  10. Article

    Formulation Development and Optimization of Famotidine Mucoadhesive Tablets by Central Composite Design

    Haranath Chinthaginjala, Mousami Bhavasar Telkar, Abdul Ahad Hindustan, Pradeepkumar Bhupalam

    pp. 1044–1051 · DOI: 10.5530/ijper.56.4.185 · Published 2022

    Objectives: The intention of present study is to formulate and optimize the famotidine mucoadhesive tablets y using Central Composite Design. Materials and Methods: The concentrations of Cordia dichotoma fruit mucilage p…

  11. Article

    Enhanced Solubility of Meloxicam with Sodium Benzoate Hydrotrope: Ecofriendly Approach for Improved Topical Drug Delivery

    Devika Tripathi, Dinesh Kumar Sharma, Jagannath Sahoo, Sunil Kumar Raman

    pp. 1052–1062 · DOI: 10.5530/ijper.56.4.186 · Published 2022

    Background: Hydrotropic solid dispersion has been reported as a potential process to improve the poor solubility of drugs using conventional hydrotropes. The presented investigation has described a water-soluble hydrotro…

  12. Article

    Design and Development of Dual Functional Colon Targeted Eudragit/Chitosan Nanoparticles: A QbD Approach

    Priyadarshini Patel, Tejas Patel

    pp. 1063–1075 · DOI: 10.5530/ijper.56.4.187 · Published 2022

    Aim: The goal of this study was to develop colon-targeted nanoparticulate systems of the anti-inflammatory agent Quercetin (QU) and evaluate the formulation for various parameters that would allow the active ingredient t…

  13. Article

    Development of Carmustine Loaded PLGA-PEG Conjugates for Nose to Brain Targeting

    Mrugendra Bhojraj Potdar, Neetesh Kumar Jain, Kiran Dayaram Patil, Yogeeta Sameer Goyal

    pp. 1076–1082 · DOI: 10.5530/ijper.56.4.188 · Published 2022

    Intranasal drug delivery is a promising route for drug delivery directly to the brain for acute or chronic treatments. A direct route to the brain offers a rapid approach to delivering drugs to the central nervous system…

  14. Article

    Face Mask Embedded with Nanoemulsion for Reducing Facial Skin Adverse Effects Caused by Prolonged Wearing the Mask during COVID-19 Management

    Reem I Alsantali, Hadel A Abo El-Enin

    pp. 1083–1090 · DOI: 10.5530/ijper.56.4.189 · Published 2022

    Background: Wearing a facemask is one of the precautionary measures for preventing coronavirus disease spread, which causes many facial skin adverse effects. Vitamin-E (TPGS) and olive oil have an efficient effect on ski…

  15. Article

    Co-administration of Coenzyme Q10 and HMG-CoA Reductase Inhibitor Attenuates Oxidative Stress, TGF-β, TNF-α, Nitrite Content and MPO Levels against Experimentally-induced Diabetic Nephropathy in Rats

    Rajesh A. Maheshwari, Ashim Kumar Sen, Ramachandran Balaraman, Nirmal V. Shah, Umang H. Shah, Nilay Solanki, Dhanya B. Sen

    pp. 1091–1098 · DOI: 10.5530/ijper.56.4.190 · Published 2022

    Objectives: Diabetes is a major disease that causes a tremendous economic burden internationally. To tackle this horrible condition, good therapeutic intervention with nutraceutical is required. These include diabetic ne…

  16. Article

    The Inhibition Effect of 2-Methoxy-1,4- naphthoquinone on Human Hepatoma Cell Lines: A in vitro and in vivo Studies

    Huaguo Liang, Ying Wen, Wei Fang, Xiaoyan Cai, Xiangsheng Wang, Li Zou, Peng Wei, Baoyun Yang, Jiazheng Lu, Yongxia Yang, Yongli Zhang

    pp. 1106–1114 · DOI: 10.5530/ijper.56.4.192 · Published 2022

    Background and Aim:To study the antitumor activity of 2-Methoxy-1,4-naphthoquinone (MNQ) against hepatocellular carcinoma (HCC) cells, in an attempt to fill the knowledge gap of anti-liver cancer with MNQ. Materials and …

  17. Article

    Discovery of Potential Inhibitors of Mycobacterium tuberculosis EthR Using Structure and Ligand Based in silico Approaches

    Bandar Hamad Aloufi, Ahmed Mohajja Alshammari

    pp. 1115–1122 · DOI: 10.5530/ijper.56.4.193 · Published 2022

    Aim and Background: Mycobacterium tuberculosis (TB) remains the leading cause of human death posing one of the most serious threats to public health around the world. New strategies need to be developed to combat the gro…

  18. Article

    Amelioration of Hepato-renal Impairment by Natural Chelators in Lead-induced Poisoning in Rats

    Quadri Neha Nausheen, Syed Ayaz Ali, Shoaeb Mohammad Syed, Tarannum Rashid Patave

    pp. 1123–1133 · DOI: 10.5530/ijper.56.4.194 · Published 2022

    Background: Hepato-Renal impairment refers to renal dysfunction in a liver compromised state concerning lead metal exposure. Natural chelators (marine source) have potent chelating properties claiming to ameliorate hepat…

  19. Article

    Detection of Novel Candidate Mutations as a Cause of Steroid-resistant Nephrotic Syndrome in Children Using Next-generation Sequencing Techniques

    Walaa F. Alsanie, Abdulhakeem S. Alamri, Turki M. Sobahy, Samar A. Zailaie, Majid Alhomrani, Moamen S. Refat, Hamza Habeeballah, Syed Mohammed Basheeruddin Asdaq, Nagaraja Sreeharsha, Ahmed Gaber

    pp. 1134–1140 · DOI: 10.5530/ijper.56.4.171 · Published 2022

    Background and Objectives:Steroid-resistant nephrotic syndrome (SRNS) is a serious chronic ailment that affects children and causes blood coagulation issues as well as an increased vulnerability to infections. Only aroun…

  20. Article

    Evaluation of Anti-cancer Activities of Cranberries Juice Concentrate in Osteosarcoma Cell Lines (MG-63)

    Aishwarya Hattiholi, Shivani Tendulkar, Vijay Kumbar, Malleswara Rao, Manohar Kugaji, Uday Muddapur, Kishore Bhat

    pp. 1141–1149 · DOI: 10.5530/ijper.56.4.195 · Published 2022

    Aim/Background: Osteosarcoma is one of the prevalent cancers occurring mostly in adolescents and has a high risk of malignancy. With complications involved in the current treatment strategies, alternates including the us…

  21. Article

    Proteomic Approach Reveals the Activation of Apoptosis by Padina gymnospora in Oral Cancer Cell Line

    Yanyuan Shi, Zhaori Getu

    pp. 1150–1155 · DOI: 10.5530/ijper.56.4.196 · Published 2022

    Aim/Background: Cancer is still known to be a devastating disease condition. Even after getting advancements in multimodality therapies, the success rate with respect to patient survival is very limited. Hence there is a…

  22. Article

    Anti-diabetic Effect of Sprouted Trigonella foenumgraecum L. Seed Solid Dosage Form in Low-dose Streptozotocin Induced Diabetic Rats

    Ashwini Kumar Mishra, Pravat Kumar Sahoo, Ganesh Lal, Meenakshi Bajpai, Hitesh Kumar Dewangan

    pp. 1156–1163 · DOI: 10.5530/ijper.56.4.197 · Published 2022

    Background: Trigonella foenum-graecum L (Fenugreek) is an annual herb, mainly cultivated for its seed as well as for its sprouts. Pharmacological investigations reported anti-bacterial, anti-diabetic, anti-cancer, anti-d…

  23. Article

    Evaluation of Methanolic Extract of Polyherbal Cream on DNCB-induced Atopic Dermatitis in Wistar Albino Rats

    G Sivakumar, Cerin Mareena Philip

    pp. 1164–1171 · DOI: 10.5530/ijper.56.4.198 · Published 2022

    Background: Atopic dermatitis, is a multifactorial chronic inflammatory and immunological disease affecting the skin, with the serious impact on psychological and life style of the patients. Unique polyherbal combination…

  24. Article

    Adhatoda vasica Possesses Anti-microbial Activity and Effectively Ameliorates Ischemia Reperfusion Injury Induced by Doxorubicin through Controlling Oxidative Stress

    Almonther Abdullah Hershan, Ahmed A Abdulhaq

    pp. 1172–1180 · DOI: 10.5530/ijper.56.4.199 · Published 2022

    Background and Objectives: Myocardial ischemia is one of the leading causes deaths among cardiac pathological conditions. Doxorubicin belongs to anthracycline class of drug which is effective against a wide variety of ne…

  25. Article

    Evaluation of the Thrombolytic and Antioxidant Activity of Leaf Extracts of Plumbago zeylanica L.

    Sarvan Kumar Guguloth, Narender Malothu, D.S.N.B.K Prasanth, Anka Rao Areti

    pp. 1181–1189 · DOI: 10.5530/ijper.56.4.200 · Published 2022

    Background: Plumbago zeylanica L. is one of the extremely accessible conventionally used herbal plants with various biological activities. However, actions of P. zeylanica L on blood clotting and other complications of b…

  26. Article

    Bio-analytical Method Development and Validation for Simultaneous Determination of Bictegravir, Emtricitabine, and Tenofovir Alafenamide Fumarate in Human Plasma by LC-MS/MS

    Attaluri Tanuja, Seru Ganapaty

    pp. 1190–1205 · DOI: 10.5530/ijper.56.4.201 · Published 2022

    Aim: The current method was developed as a novel and reliable quantitative liquid chromatography-mass (tandem) spectrometry (LC-MS/MS) method for the estimation of analytes like Bictegravir (BIC) Tenofovir Alafenamide Fu…

  27. Article

    Development and Validation of a Stability-indicating Method for Neostigmine Bromide: Separation, Identification and Characterization of Degradation Product using LC-MS and ESI-Q-TOF-MS/MS

    Rajan Makkar, Jitender Singh, Monika Bhardwaj, Lovekesh Mehta, Parul Grover

    pp. 1206–1218 · DOI: 10.5530/ijper.56.4.202 · Published 2022

    Objectives: Forced degradation study of the drug product and drug substance is very much important in drug development and drug discovery to establish the intrinsic stability and understand its behaviors towards differen…

  28. Article

    Evaluation of pH Dependent Solubility and Examination of Variation in Pharmacokinetic Properties of Alectinib: A Quantitative Study by Implementing Integrated Quality by Design Approach for RP-HPLC Method Development and Optimization

    Durga Deepthi Kolasani, Mrunal Desai, Prajakta Patil, Jagadish Puralae Channabasavaiah

    pp. 1219–1225 · DOI: 10.5530/ijper.56.4.203 · Published 2022

    Introduction: Alectinib, an anaplastic lymphoma kinase inhibitor of BCS class IV, is said to have pH-dependent solubility and is susceptible to interactions with co-prescribed acid-reducing agents. Objectives: A micro-di…

  29. Article

    The Prevalence of Anemia and Hematological Findings in COVID-19 Patients in Saudi Arabia

    Mazen Almehmadi, Magdi Salih, Ayman Al-hazmi, Muhannad Alenazi, Osama Abdulaziz, Faisal Almalki, Alaa Shafie, Naif Alsiwiehri, Mamdouh Allahyani, Njoud Althibity, Ebtisam Alosimi, Abdullah Turjoman, Fatimah Rebh, Abdulelah Aljuaid, Mustafa Halawi

    pp. 1226–1231 · DOI: 10.5530/ijper.56.4.204 · Published 2022

    Objectives: The aim of this study was to estimate the prevalence of anemia among COVID-19 patients in Saudi Arabia and evaluate their hematological parameters. Materials and Methods: A descriptive, cross-sectional, hospi…

  30. Article

    Evaluation of Health-related Quality of Life among Hypertensive Post-menopausal Women Using EQ-5D in India During COVID-19 Pandemic

    Thangamani Subramani, Saravanan Kunchithapatham, Sajeeth Chadappully Ismail

    pp. 1232–1239 · DOI: 10.5530/ijper.56.4.205 · Published 2022

    Background: Hypertension and menopause are interrelated factors to determine the quality of life (QOL) in women. Covid-19 was related to massive public anxiety, it is critical to know the level of influence in such pande…

  31. Article

    Attributes of Private Pharmacy School Graduates as Care Providers: A Cross-sectional Study from Saudi Arabia

    Saleh Fahad Alqifari

    pp. 1240–1244 · DOI: 10.5530/ijper.56.4.206 · Published 2022

    Objectives: This study aimed to measure the level of preparedness of recent pharmacy program graduates to deliver patient care. Materials and Methods: A cross-sectional study was conducted using a validated self-administ…

  32. Article

    Garlic Mediated Green Synthesis of Silver Nanoparticles as Antifungal Agents against Magnaporthe oryzae

    Bahareh Bakhshi, Sudhakar Malla, Lokesh Siddalinge Gowda

    pp. 1245–1252 · DOI: 10.5530/ijper.56.4.207 · Published 2022

    Background: Plant elements such as carbohydrates, lipids, flavonoids, polyphenols, enzymes, terpenoids, and alkaloids are used as reducing substance in the green production of silver nanoparticles. The strategy proved to…