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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

New Data for Endemic Phlomis cypria Post from North Cyprus: Biological Activities and LC MS/MS Analysis

İmge Kunter1, Mohammed Tamim Tarabishi1, Niloufar Zabib1, Tuğba Erçetin1, Mehmet İlktaç1, Fatih Göger2,3, Müberra Koşar1★★ Corresponding author

  1. 1Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus via Mersin-10, TURKEY.
  2. 2Faculty of Pharmacy, Department of Pharmacognosy, Tepebaşı, Eskişehir, TURKEY.
  3. 3Department of Pharmacy, Program in Pharmacy Services, Yunus Emre Vocational School, Anadolu University, Tepebaşı, Eskişehir, TURKEY.

CORRESPONDENCE

Müberra Koşar

Prof. Dr. Müberra Koşar, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus via Mersin-10, TURKEY.

muberra.kosar@emu.edu.tr

Received: 18-12-2021; Revised: 28-03-2022; Accepted: 24-06-2022.

Volume 57, Issue 2 · pp. 511–518 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.2.62

View on IJPER original site ↗

ABSTRACT

Background: The genus Phlomis includes up to 100 species which are distributed throughout Eurasia. Of these species, Phlomis cypria Post (Lamiaceae) is an endemic plant from North Cyprus. P. cypria is commonly used in North Cyprus as medicinal herbal tea for the winter cold and flu. Phlomis species have antioxidant, antimicrobial and anticancer effects. Materials and Methods: In this study, herbal part of P. cypria from North Cyprus was sequentially extracted using hexane, dichloromethane and 70% aqueous methanol and using maceration at room temperature. All extracts were investigated for antiradical (DPPH● and ABTS+●), anticholinesterase, antibacterial and the cytotoxic activities and additionally, chemical compositions of the extracts were evaluated by LC MS/MS method. Results: Aqueous methanol extract showed antiradical activities (IC₅₀ 0.29 mg/mL in DPPH●; TEAC 1.22, 1.36 in ABTS+●) and cytotoxic activities (IC₅₀ 1264 µg/mL on SK-HEP 1 cells). Dichloromethane extract only showed activity in anticholinesterase assay (inhibitions were 37.68% for AChE; 21.73% for BChE). Forsytoside B was found as the main phenolic compound in the active extract with caffeic acid bound to other compounds. Conclusion: According to the results, P. cypria could be a potential candidate as cytotoxic and cholineasterase inhibitor agent.

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    Kunter, M., Tarabishi, M. T., Zabib, N., Erçetin, T., İlktaç, M., Göger, F., & Koşar, M. (2023). New Data for Endemic Phlomis cypria Post from North Cyprus: Biological Activities and LC MS/MS Analysis. Indian Journal of Pharmaceutical Education and Research, 57(2), 511–518. https://doi.org/10.5530/ijper.57.2.62