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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Evaluation of Potentiality of Salvia hispanica in the Management of Irritable Bowel Syndrome in Wistar Albino Rats

Ashish1, Avijit Mazumder1★, Sanjita Das1★ Corresponding author

  1. 1Department of Pharmacology, Noida Institute of Engineering and Technology(Pharmacy Institute), Greater Noida, Uttar Pradesh, INDIA.

CORRESPONDENCE

Avijit Mazumder

Director and Professor, Department of Pharmacology, Noida Institute of Engineering and Technology, Pharmacy Institute, Greater Noida-201308, Uttar Pradesh, INDIA.

avijitmazum@yahoo.com

Received: 17-10-2022; Revised: 29-11-2022; Accepted: 31-12-2022.

Volume 57, Issue 2S · pp. s353–s359 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.2s.41

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ABSTRACT

Introduction: Globally, approximately 11% of the population has been affected by the irritable bowel syndrome. Recent advancement in medical area have made it easily possible to find out the proper pathophysiology behind the generation of symptoms of irritable bowel syndrome followed by its treatment. Objective: The aim of this research is to check the effect of mucilage of Salvia hispanica on gastrointestinal tract symptoms (IBS) as a result of excessive fibers availability in the mucilage. Materials and Methods: The anti-IBS activity was seen in rats by using the various animal experimental models. The anti-IBS activity of Salvia hispanica mucilage (100 mg/kg, p.o.) in rats was checked by using the Water Avoidance Stress Model (WAS), Food Related model of IBS and Croton oil Induced Hemorrhoids. For the estimation of effect of monoamine on GIT fluorimeter was used to check the level of serotonin and iliac motility of rats were also checked. Results: It was found out that Salvia hispanica mucilage had contractile action on iliac motility that leads to the shortening the evacuation time of bowel and relief in constipation. From the data collected by using above methods. Conclusion: It was concluded that the Salvia hispanica mucilage revealed to possess activity against IBS significantly (****p<0.0001) at a dose of 100 mg/kg. Activity against IBS was supported by enhanced serotonin level in the gastrointestinal tract.

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    Ashish, Mazumder, A., & Das, S. (2023). Evaluation of Potentiality of Salvia hispanica in the Management of Irritable Bowel Syndrome in Wistar Albino Rats. Indian Journal of Pharmaceutical Education and Research, 57(2S), s353–s359. https://doi.org/10.5530/ijper.57.2s.41