Volume 57, Issue 2S

PLGA: A Wow Smart Biodegradable Polymer in Drug Delivery System

Sonali S Sonawane, Prashant L Pingale, Sunil V Amrutkar

pp. s189–s197 · DOI: 10.5530/ijper.57.2s.23 · Published 2023

Aim: This article describes how biodegradable polymers and their drug delivery mechanisms can be used to monitor and maintain local or targeted drug distribution. Polylactic-co-glycol acid has been one of the most appeal…

Antidiabetic Properties of Natural Products of Cyperus Species Plants: A Review

Ayusman Swain

pp. s226–s233 · DOI: 10.5530/ijper.57.2s.26 · Published 2023

Natural products are reported to have a vital role in the treatment of various diseases and drug design. In recent developments, natural drug molecules of plant origin have been reported exclusively for diabetic manageme…

Formulation and Evaluation of Double-layered (Matrix and Drug-in-adhesive) Transdermal Patches of Diclofenac Diethylamine: In vitro and ex vivo Permeation Studies

Aditya Sharma, Navneet Verma

pp. s234–s243 · DOI: 10.5530/ijper.57.2s.27 · Published 2023

Background: The objective of this current study was to fabricate and characterize the sustained release double layered transdermal patches of Diclofenac Diethylamine using hydrophobic acrylic polymer Eudragit RL 100 and …

A Recent Review on Synthesis, Characterization and Activities of Gold Nanoparticles Using Plant Extracts

Sheeja Koliyote, Jessy Shaji

pp. s198–s212 · DOI: 10.5530/ijper.57.2s.24 · Published 2023

Despite advances in synthetic medications, medicinal herbs have empowered mankind with a wide range of efficacious medicines to lessen or eliminate illnesses and suffering from diseases. Since the last decade there has b…

Formulation and Characterization Sustained Release Mucoadhesive Microcapsule of Baclofen

Kunal V Bhambar, Rajendra S Bhambar, Pravin P Gadakh

pp. s244–s249 · DOI: 10.5530/ijper.57.2s.28 · Published 2023

Background: Baclofen is used as skeletal muscle relaxant. Baclofen inhibit Polysynaptic and monosynaptic reflexes a hyperpolarisation. Baclofen drug absorbed rapidly and excreted in feces urine in unchanged form. Objecti…

Topical Film Forming Clotrimazole Emulgel

Harsha Kathpalia, Aditi Venkatesh, Neha Sathe

pp. s250–s261 · DOI: 10.5530/ijper.57.2s.29 · Published 2023

Introduction: Clotrimazole is a weak base and is practically insoluble in water. To enhance drug loading of hydrophobic Clotrimazole in the formulation and, to circumvent greasiness, poor retention time and easy wipe off…

Design Formulation and Statistical Evaluation of Gastroretentive Microspheres of Rasagiline Mesylate for Parkinson’s Disease Using Design Expert

R Prasanthi, B Haarika, S Selvamuthukumar

pp. s262–s273 · DOI: 10.5530/ijper.57.2s.30 · Published 2023

Introduction: Rasagiline mesylate is primarily prescribed to treat the symptoms of idiopathic Parkinson's disease works as irreversible inhibitor of mono amino oxidase. The microspheres were designed for extended retenti…

Mucoadhesive Films of Liquorice and Chlorhexidine Gluconate for Treating Mouth Ulcers

Shreyashi Mazumdar, Bala Prabhakar, Shraddha Ishwar Khairnar, Kavita Singh

pp. s274–s280 · DOI: 10.5530/ijper.57.2s.31 · Published 2023

Objectives: Mouth ulcer is a rupture or breaks in the oral mucosal membrane and it leads to atrophy and ulcers in the oral cavity. It increases the risk of infections with the Candida species Inherited trauma and aphthou…

Quality by Design Driven Development of Topical Gel Encompassing Papain and Bromelain to Elicit Wound Healing

Mahendra Gunde, Darshan Telange, Awdhut Pimpale, Anil Pethe

pp. s281–s291 · DOI: 10.5530/ijper.57.2s.32 · Published 2023

Background: Topical gels are an efficient and targeted therapy for local dermatological problems because they distribute medications effectively and are easy to wipe off the skin. The presented study was aimed to use Qua…

Enhanced Solubility and Dissolution of Drug-drug Cocrystals of Lopinavir-Ritonavir

Khushbu R Chaudhari, Jignasa K Savjani, Ketan T Savjani, Sandeep Dahiya, Jitendra O Bhangale

pp. s292–s300 · DOI: 10.5530/ijper.57.2s.33 · Published 2023

Introduction: Drug-drug cocrystals of Lopinavir and Ritonavir were designed and characterized. In view of literature, Ritonavir increases the oral bioavailability of Lopinavir in low dosage. Aim: The present research aim…

Biofabrication and Characterization Using Egg Shell Nanoparticles and their Haemolytic Analysis: An in-vitro Study

Y Dinesh, Satheesh Kumar Balu, Karthikeyan Ramalingam, Pratibha Ramani

pp. s301–s306 · DOI: 10.5530/ijper.57.2s.34 · Published 2023

Aim/Background: Hydroxyapatite is a bioactive, biocompatible, and osteoconductive component having similar chemical characteristics to bone and tooth mineral components. Due to its porous structure and resistance to high…

Inhalable Solubilized Zileuton for Improved Lung Targeting in vitro and in vivo Analysis

Afzal Haq Asif, Girish Meravanige, Sreeharsha Nagaraja, Arshia Shariff, Juturu Thimmasetty, Kavitha Arenur Narayana

pp. s307–s314 · DOI: 10.5530/ijper.57.2s.35 · Published 2023

Background: Pulmonary diseases that affect the normal functioning of the lungs show airway symptoms ranging from change in airflow to bronchiectasis. Zileuton is an inhibitor of 5-lipoxygenase enzyme that catalyzes the s…

Comparison between Olive Oil and Nano-Bio Fusion Gel and their Role in the Treatment of Alveolar Osteitis: A Double-Blind Randomized Trial

Zafar Ali Khan, Namdeo Prabhu, Naseer Ahmed, Rakhi Issrani

pp. s315–s320 · DOI: 10.5530/ijper.57.2s.36 · Published 2023

Background: Alveolar osteitis is a painful condition that occurs after tooth extraction. This condition has been treated with various chemical and herbal formulations that are found to be efficacious with different succe…

Role of Remifentanil on MAC, Bcl-2, and Bax Levels in Traumatic Brain Injury Rat Models

Ardana Tri Arianto, Soetrisno, Purwoko, Dono Indarto

pp. s321–s326 · DOI: 10.5530/ijper.57.2s.37 · Published 2023

Introduction: Traumatic Brain Injury (TBI) conditions require immediate treatment such as the administration of analgesics and sedation, including remifentanil. TBI will affect the levels of several inflammatory and apop…

Preparation and Characterization of Silver Nanoparticle Cross-linked Polymeric Cages by Freshwater Cyanobacteria and their Bactericidal Evaluation against Multi-Drug Resistant Bacteria

Gunaswetha Kuraganti, Sujatha Edla, Swetha Viddamuri

pp. s327–s334 · DOI: 10.5530/ijper.57.2s.38 · Published 2023

Introduction: Over the past 60 years, numerous modern types of antibiotics have been developed. Antibiotic overuse has been largely responsible for spreading resistant strains that endangering the public's health at an a…

Authentication of Averrhoa carambola L. Using DNA Barcoding: Detection of SNPs and Evaluation of Phylogenetic Relationship

Alok Kumar Giri, Bhagyashree Biswal, Biswajit Jena, Laxmikanta Acharya

pp. s335–s344 · DOI: 10.5530/ijper.57.2s.39 · Published 2023

Background: Averrhoa carambola L. (star fruit) is an underutilized plant in the family Oxalidaceae. The plant has various pharmacological activities and has fleshy juicy fruit with high nutritional value and is rich in v…

Finding the Principle Leads using GC-MS and Unravelling the Anti-inflammatory Activity of Alkaloid Isolated from Caesalpinia bonducella by in vitro Techniques

Sandhiya Mathiyazhagan, Hrishita Yadav, Ramya Vishwanathan, Amala Reddy

pp. s345–s352 · DOI: 10.5530/ijper.57.2s.40 · Published 2023

Aim/Background: Plant-based medicines have gained remarkable recognition recently, as consumers have begun to express their preference for herbal remedies. C. bonducella, commonly known as fever nut, is said to have mass…

Evaluation of Potentiality of Salvia hispanica in the Management of Irritable Bowel Syndrome in Wistar Albino Rats

Ashish, Avijit Mazumder, Sanjita Das

pp. s353–s359 · DOI: 10.5530/ijper.57.2s.41 · Published 2023

Introduction: Globally, approximately 11% of the population has been affected by the irritable bowel syndrome. Recent advancement in medical area have made it easily possible to find out the proper pathophysiology behind…

Evaluation of Chemo-Preventive Effect of Methanolic Fruit Extract of Cucumis melo var. agrestis on DEN-Induced HCC in Sprague Dawley Rats

G Sivakumar, S Anjala Devi

pp. s360–s369 · DOI: 10.5530/ijper.57.2s.42 · Published 2023

Aim: To investigate chemo-preventive effect of methanolic fruit extract of Cucumis melo var. agrestis on DEN (diethyl-nitrosamine) induced hepatocellular carcinoma in Sprague Dawley rats. Materials and Methods: Five grou…

Toxicological Study of n-hexane and Chloroform Extracts of Lantana camara L. in Experimental Animals

Sribatsa Lanchhana Dash, Ranjit Mohapatra, Suman Kumar Mekap, Smruti Ranjan Masanta, Arpit Katiyar, Nitin Sharma, Ritu Karwasra, Sagar Kumar Mishra

pp. s370–s380 · DOI: 10.5530/ijper.57.2s.43 · Published 2023

Aim: The aim of the current study is to investigate the acute, sub-acute and sub-chronic toxicity study of extracts (n-hexane and chloroform) of L. camara in Wistar rats. Materials and Methods: HPTLC and GC-MS analysis w…

Nutritional Assessment of Invasive Alien Plants as Bioprospecting Resources in Mizoram, an Indo-Burma Mega Biodiversity Hotspot in India

Rabishankar Sengupta, Sudhansu Sekhar Dash, Tapan Seal

pp. s381–s390 · DOI: 10.5530/ijper.57.2s.44 · Published 2023

Background: The nutritional value, antinutritional properties, mineral and Vitamin content of six invasive Alien Plant species (IAPs) namely Ageratina adenophora, Ageratina riparia, Chromolaena odorata, Ocimum americanum…

In vivo Performance of a Hydrogel of Tribulus terrestris in Alloxan induced Diabetic Rats

Sheelu Singh, Shweta Kumar, Phool Singh Yaduvanshi, Rajesh Singh Pawar

pp. s391–s398 · DOI: 10.5530/ijper.57.2s.45 · Published 2023

Background: Diabetes is one of the most important factors in chronic injuries. The gold standard for treating diabetic foot ulcers includes debridement of wounds, management of all infections, revascularization when indi…

Design, Synthesis and Biological Screening of Novel Carbazole Tethered Oxyethylamino Derivatives as Antimicrobial Agent

Prafulla M Sabale, Nusrat B Sayyad, Lata C Potey

pp. s399–s404 · DOI: 10.5530/ijper.57.2s.46 · Published 2023

Background: Carbazole is an important scaffold known to be associated with several biological activities including antimicrobial activities. Incorporation 4-oxothiazolidine moiety in carbazole moiety may lead to a new se…

Management of Anxiety in Coronary Artery Bypass Grafting Patients: The Influence of Chair Aerobics and Nadisodhana Pranayama-A Pilot Randomized Clinical Trial

Abeeshna Ashok, Dhanesh Kumar KU, Gopalakrishnan Mundayat

pp. s405–s410 · DOI: 10.5530/ijper.57.2s.47 · Published 2023

Background: Anxiety is a primary concern affecting the prognosis of CABG patients. Relieving anxiety is thus a component of management in patients with CABG. We use two feasible and cost-effective treatment techniques to…

Rutin Inhibits Hepatic and Pancreatic Cancer Cell Proliferation by Inhibiting CYP3A4 and GST

Bandar A Alyami, Mohammad Zaki, Mahmoud Youns, Bassim Amin, Randa Abdou, Mohamed Dawoud, Gouda H Attia

pp. s411–s418 · DOI: 10.5530/ijper.57.2s.48 · Published 2023

Background: Digestive cancer is among the major causes of mortality and morbidity worldwide. Rutin, a bioactive secondary metabolite belonging to flavonoids and distributed in many fruits and vegetables has shown anti-pr…

Determination of Wound Healing Potential of Pharmaceutical Formulations (Gel and Paste) Prepared by Using Sea Water Snail

Deepak P. Pawar, Prashant B. Shamkuwar

pp. s419–s423 · DOI: 10.5530/ijper.57.2s.49 · Published 2023

Background: Marine species have long been valued as both nutritious foods for human diets and as a good source of medicinal chemicals. Purpose: The present work aimed to investigate wound healing potential of prepared ge…

Development of Pharmacognostic Profile and Preliminary Phytochemical Study of Pluchea wallichiana DC

Kinjal Bera, Madhavi Patel

pp. s424–s433 · DOI: 10.5530/ijper.57.2s.50 · Published 2023

Introduction: The genus Pluchea comprises of around 80 species native to tropical and warm temperate areas. It has been traditionally known as rasna and used to treat different ailments including inflammation and arthrit…

Design and Development of Oxyclozanide Chewable Tablet Formulation Employing Quality by Design Approach

Yildiz Ozalp, Adel Aboubakr, Motunrayo Mayowa Onayo, Hassen Kebede, Nailla Jiwa, Nese Buket Aksu

pp. s434–s441 · DOI: 10.5530/ijper.57.2s.51 · Published 2023

Background: The focus of this research was to identify undiscovered knowledge associated with the production of oxyclozanide tablets utilizing Quality by Design (QbD) in order to develop an ideal formulation that would g…

Molecular Docking and in vitro Enzyme Assay of Bioactive Compound Isolated from Rhus tripartite Collected from Hail Region of Saudi Arabia as Potential Anti-Diabetic Agent

Aziz Unnisa, Rama Devi Kunduru, Suresh Babu Jandrajupalli, Badria Awad Elamine, Humerah Banu, Anupama Baratam, Sharukh Khan

pp. s442–s452 · DOI: 10.5530/ijper.57.2s.52 · Published 2023

Aim: In the present investigation, we have studied the inhibitory potential of a bioactive compound isolated from Rhus tripartite on Glucokinase (GK), Dipeptidyl Peptidase-IV (DPP-IV), alpha-glucosidase, and alpha-amylas…

Antiproliferative Activity of Novel Imatinib Analogue as Potential Anticancer Agents, Synthesis and in vitro Screening

Kavita Sangwan, Balvinder Singh

pp. s453–s458 · DOI: 10.5530/ijper.57.2s.53 · Published 2023

Background: A series of N-(2,5-dimethylphenyl)-4-pyridin-3-ylpyrimidin-2-amine derivatives were synthesized as Imatinib derivatives, bearing 2-chloroquinoline as a heteroaryl motif. Materials and Methods: The compounds w…

Binding of Novobiocin Paves the Way for Inhibition of DEAH-box Helicase 8

Mohammad Rehan Ajmal, Fahad Mohammad Almutairi, Arif Hussain, Mohammad Fahad Ullah, M Ayaz Ahmad, Ali Saber Abdelhameed, Hussain Arif

pp. s459–s464 · DOI: 10.5530/ijper.57.2s.54 · Published 2023

Introduction: DEAH-box helicase 8 (DHX8) is a crucial DEAH-box RNA helicase involved in splicing and required for the release of mature mRNA from the splice. Here, we report the interaction study of human DHX8 and four t…

Editorial: Navigating the Frontiers in Pharmaceutical Sciences: A Digest of Review and Original Articles

M. Ahmed

pp. si · DOI: · Published 2023