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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

In vivo Performance of a Hydrogel of Tribulus terrestris in Alloxan induced Diabetic Rats

Sheelu Singh1,2, Shweta Kumar2,3, Phool Singh Yaduvanshi1, Rajesh Singh Pawar2,4★★ Corresponding author

  1. 1Department of Pharmacy, IES Institute of Pharmacy, IES University Campus, Kalkheda, Ratibad Main Road, Bhopal, Madhya Pradesh, INDIA.
  2. 2Faculty of Pharmacy, VNS Group of Institutions, VNS Campus, Neelbud, Bhopal, Madhya Pradesh, INDIA.
  3. 3Department of General Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, INDIA.
  4. 4Department of Pharmacy,Truba Institute of Pharmacy, Truba Group of Institutes, Karond Bypass Rd, Gandhi Nagar, Bhopal, Madhya Pradesh, INDIA.

CORRESPONDENCE

Rajesh Singh Pawar

Truba Institute of Pharmacy, Truba Group of Institutes, Bypass Rd, Gandhi Nagar, Bhopal-462038, Madhya Pradesh, INDIA.

dr_pawar14@rediffmail.com

Received: 13-02-2022; Revised: 22-06-2022; Accepted: 12-12-2022.

Volume 57, Issue 2S · pp. s391–s398 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.2s.45

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ABSTRACT

Background: Diabetes is one of the most important factors in chronic injuries. The gold standard for treating diabetic foot ulcers includes debridement of wounds, management of all infections, revascularization when indicated, and non-loading of ulcers. Traditionally, the aerial parts of Tribulus terrestris L. (Zygophyllaceae) are used in the folklore for the treatment of various kinds of wounds. Materials and Methods: Based on the evaluation of phytochemicals, a hydrogel of the hydroalcoholic and the aqueous of T. terrestris were prepared in this study. It was subjected to evaluation of the different parameters. The hydrogel of hydroalcoholic extract and aqueous extract was brown in color, uniform and non-irritant. It was further evaluated for pH, spreadability and viscosity. Furthermore, the in vivo performance of the hydrogel was evaluated in alloxan monohydrate induced diabetic rats. Results: In excision wound model and incision wound model topical application of 5% hydroalcoholic extract hydrogel in diabetic Wistar albino rat showed remarkable repair effects. It significantly (***p<0.001) enhanced the rate of % wound contraction. It also exhibited significant (***p<0.001) content of hydroxyproline and extremely high tensile strength (***p<0.001) as compared to the diabetic control group. It may be due to enhanced collagen synthesis. The histopathological examination of 5% hydroalcoholic extract hydrogel of T. terrestris L. treated rats showed skin architecture which was comparable to the normal group. The diabetes-induced group rats’ wounds failed to heal even 25 days post the infliction of the wounds. Our model precisely reproduced the pathophysiology of diabetic ulcers and can serve as a valid alternative model for diabetic foot ulcer and to explore new therapies. Conclusion: The results strongly support that the hydrogel of the hydroalcoholic extract of T. terrestris seems to be a novel and promising biomaterial used for wound healing applications.

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    Singh, S., Kumar, S., Yaduvanshi, P. S., & Pawar, R. S. (2023). In vivo Performance of a Hydrogel of Tribulus terrestris in Alloxan induced Diabetic Rats. Indian Journal of Pharmaceutical Education and Research, 57(2S), s391–s398. https://doi.org/10.5530/ijper.57.2s.45