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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Design, Synthesis and Biological Screening of Novel Carbazole Tethered Oxyethylamino Derivatives as Antimicrobial Agent

Prafulla M Sabale1★, Nusrat B Sayyad1, Lata C Potey2★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road, Nagpur, Maharashtra, INDIA.
  2. 2School of Pharmacy, G. H. Raisoni University, Saikheda, Madhya Pradesh, INDIA.

CORRESPONDENCE

Prafulla M Sabale

Dr. Prafulla M. Sabale,Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur-440033, Maharashtra, INDIA.

prafullasable@yahoo.com

Received: 03-06-2022; Revised: 25-12-2022; Accepted: 07-03-2023.

Volume 57, Issue 2S · pp. s399–s404 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.2s.46

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ABSTRACT

Background: Carbazole is an important scaffold known to be associated with several biological activities including antimicrobial activities. Incorporation 4-oxothiazolidine moiety in carbazole moiety may lead to a new series of antimicrobials compounds. Aim: In this study, design and synthesis of novel carbazole tethered oxyethylamino was started with carbazole as basic pharmacophore and evaluated for antimicrobial activity. Materials and Methods: Molecular docking of carbazole derivatives was carried out by Schrödinger (Maestro 10.5v) active compound were Synthesized and screened for in vitro antimicrobial activity against Candida albicans and gram-positive and gram-negative bacterial strains such as Staphylococcus aureus, Bacillus subtilis, E. coli. MIC was calculated by standard agar tube dilution method. Results: All Compounds shown good antimicrobial activity at 25 (µg/ml) – 510 (µg/ml). The molecular docking studies demonstrated ligand protein interaction. Conclusion: carbazole represent novel set of lead for the designing of novel antimicrobial agents.

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    Sabale, P. M., Sayyad, N. B., & Potey, L. C. (2023). Design, Synthesis and Biological Screening of Novel Carbazole Tethered Oxyethylamino Derivatives as Antimicrobial Agent. Indian Journal of Pharmaceutical Education and Research, 57(2S), s399–s404. https://doi.org/10.5530/ijper.57.2s.46