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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Review

Nanosizing Approaches: Current Trends in the Solubility Enhancement of Poorly Water-soluble Drugs

Satish Shilpi1, Ekta Gurnany2, Shvetank Bhatt3, Pawan K Gupta4, Neeraj K Sethiya1, Vikas Jain5, Rupshee Jain6★★ Corresponding author

  1. 1Department of Pharmaceutics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, INDIA.
  2. 2Department of Pharmaceutics, B. Pharmacy College, Rampura, Godhra, Gujarat, INDIA.
  3. 3Department of Pharmacology, School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune, Maharashtra, INDIA.
  4. 4Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, INDIA.
  5. 5Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Karnataka, INDIA.
  6. 6Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA.

CORRESPONDENCE

Rupshee Jain

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru-570015, Karnataka, INDIA.

rupsheejain@jssuni.edu.in

Received: 08-12-2022; Revised: 12-02-2023; Accepted: 13-04-2023.

Volume 57, Issue 3 · pp. 625–639 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.3.77

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ABSTRACT

Nanosuspension formulation and production techniques are currently undergoing remarkable growth in pharmaceutical industries to address poor aqueous solubility and low bioavailability of active pharmaceutical ingredients. It has some distinct character and benefits over other methodologies used to enhance aqueous solubility. The controlled process including formulation and processing variables provide the requisite shape and size of the drug particles in the form of nanosuspension. Generally, drug particles in the form of nanosuspension can be obtained in the size range of 200 to 1000 nm by manipulating various parameters. The pharmacokinetic parameters of the drugs can also be altered by changing the size of drug particles by developing them in the form of nanosuspension. The current review aims to address the physico-chemical characteristics of nanosuspensions, including various formulation considerations. This review also includes potential applications and recent advancements in the field of nanosizing technology.

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    Shilpi, S., Gurnany, E., Bhatt, S., Gupta, P. K., Sethiya, N. K., Jain, V., & Jain, R. (2023). Nanosizing Approaches: Current Trends in the Solubility Enhancement of Poorly Water-soluble Drugs. Indian Journal of Pharmaceutical Education and Research, 57(3), 625–639. https://doi.org/10.5530/ijper.57.3.77