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Indian Journal of Pharmaceutical Education and ResearchNOW IN
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Advances in in vivo Non-invasive Delivery of Gentamicin

Arka Bhattacharjee1★, Arpan Chakraborty1, Nitai Chand Chaulya2, Goutam Mukhopadhyay3★ Corresponding author

  1. 1Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Nadia, West Bengal, INDIA.
  2. 2Department of Pharmaceutical Technology, Gupta College of Technological Sciences, Asansol, West Bengal, INDIA.
  3. 3Department of Pharmaceutical Technology, BCDA College of Pharmacy and Technology, Kolkata, West Bengal, INDIA.

CORRESPONDENCE

Arka Bhattacharjee

Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Nadia-741 249, West Bengal, INDIA.

arka007.online@gmail.com

Received: 04-12-2022; Revised: 28-04-2023; Accepted: 30-06-2023.

Volume 57, Issue 3 · pp. 648–657 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.3.79

View on IJPER original site ↗

ABSTRACT

Introduction: Parenteral administration of gentamicin is a globally known therapeutic strategy for severe infections, including severe community acquired pneumonia, complex severe acute malnourishment, neonatal and pediatric sepsis. The drug is also prescribed as an ophthalmologic anti-infective. In most cases, the therapeutic course necessitates frequent bolus medication doses, lengthy hospitalization, and ongoing therapeutic monitoring; hence a qualified healthcare provider is required. Objectives: Gentamicin is a hydrophilic drug and has a short half-life, making it difficult to achieve appropriate systemic concentrations when taken parenterally. The use of innovative oral medication delivery systems is justified in this context. Furthermore, new delivery strategies can increase the membrane permeability of gentamicin. Conclusion: The current analysis provides a detailed summary of gentamicin's research history as well as several developing drug delivery strategies that have been explored. The examples included in the paper give important evidence on innovative delivery systems for gentamicin in the domain of antimicrobial investigations opening a way for upcoming therapeutics that may provide better clinical outcomes.

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    Bhattacharjee, A., Chakraborty, A., Chaulya, N. C., & Mukhopadhyay, G. (2023). Advances in in vivo Non-invasive Delivery of Gentamicin. Indian Journal of Pharmaceutical Education and Research, 57(3), 648–657. https://doi.org/10.5530/ijper.57.3.79