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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Boswellic Acid Loaded Nanoemulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, in vitro, ex vivo, and in vivo Evaluation

Yogesh Mahadeo Amgaonkar1★, Nitin Indarchand Kochar1, Anil Vishwanath Chandewar1, Milind Janrao Umekar2, Kamlesh Jayantilal Wadher2★ Corresponding author

  1. 1Department of Pharmaceutics, Yavatmal Zilla Vikas Samiti's Pataldhamal Wadhwani College of Pharmacy, Yavatmal, Maharashtra, INDIA.
  2. 2Department of Pharmaceutics, Smt Kishoritai Bhoyar College of Pharmacy, Kamptee, Maharashtra, INDIA.

CORRESPONDENCE

Yogesh Mahadeo Amgaonkar

Department of Pharmaceutics, Yavatmal Zilla Vikas Samiti's Pataldhamal Wadhwani College of Pharmacy, Yavatmal, Maharashtra, INDIA.

yamgaonkar123@gmail.com

Received: 24-06-2023; Revised: 23-10-2023; Accepted: 12-12-2023.

Volume 58, Issue 2 · pp. 546–554 · PUBLISHED 2024 · DOI: 10.5530/ijper.58.2.61

View on IJPER original site ↗

ABSTRACT

Background: Topical delivery of medication is often considered to be the best choice due to benefits such as avoidance of gastric degradation, first pass metabolism along with effortless application and retrieval. In topical delivery, the types of the vehicles and the physicochemical characteristics of drug are the prime variables that control the drug release and the therapeutic efficacy. The main component of Boswellia, Boswellic Acid (BA), is assumed to be accountable for the majority of pharmacologic effects. Nanoemulgel combines the benefits of nano-emulsions and the gels. Materials and Methods: The present work carried out with an objective of formulation of topical nanoemulgel of boswellic acid containing carbopol 934 and liquid paraffin as oil base. Results: The prepared nanoemulgel characterized for the various parameters such as, in vitro, ex vivo permeation and in vivoanti-inflammatory activity. The optimized nanoemulsion consisted of carbopol 934 and surfactant mix ratio (tween 80:Span20::1:1), in 1, 1.5 and 2 % w/w. Thein vitro, ex vivopermeation of BA from nanoemulgel were found to be 90±0.33% and 85.5±1.2% at 12 hr respectively. Conclusion: Topical application of BA nanoemulgel formulation significantly reduced the inflammation by reducing the serum IL-6 concentration compared with the arthritic rats. The research findings showed that BA nanoemulgel has the ability to increase penetration through the skin and produce an anti-inflammatory impact.

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    Amgaonkar, Y. M., Kochar, N. I., Chandewar, A. V., Umekar, M. J., & Wadher, K. J. (2024). Boswellic Acid Loaded Nanoemulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, in vitro, ex vivo, and in vivo Evaluation. Indian Journal of Pharmaceutical Education and Research, 58(2), 546–554. https://doi.org/10.5530/ijper.58.2.61