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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Anticancer and Hepatoprotective Role of Selenium Nanoparticles against Liver Carcinogen Acrylamide Induced Toxicity: In vitro and in vivo Studies

Uzma Faridi1★, Nahla Zidan1,2, Hebbatallah Atteia3,4, Yahya Al-Awthan5,6, Adel I Alalawy1, Md. Qussen Akhtar7, Mohamed Sakran1,8, Humaira Parveen9★ Corresponding author

  1. 1Department of Biochemistry, University of Tabuk, Tabuk, SAUDI ARABIA.
  2. 2Department of Home Economics, Faculty of Specific Education, Kafr ElShaikh University, Kafr El-Sheikh Governorate, EGYPT.
  3. 3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, SAUDI ARABIA.
  4. 4Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT.
  5. 5Department of Biology, University of Tabuk, Tabuk, SAUDI ARABIA.
  6. 6Department of Biology, Faculty of Science, Ibb University, Ibb, YEMEN.
  7. 7Biotechnology Divisions, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, INDIA.
  8. 8Department of Chemistry, Faculty of Sciences, Tanta University, Tanta, EGYPT.
  9. 9Department of Chemistry, University of Tabuk, Tabuk, SAUDI ARABIA.

CORRESPONDENCE

Uzma Faridi

Department of Biochemistry, University of Tabuk, Tabuk, SAUDI ARABIA.

ufaridi@ut.edu.sa

Received: 12-09-2023; Revised: 01-12-2023; Accepted: 09-03-2024.

Volume 58, Issue 3 · pp. 830–836 · PUBLISHED Jul-Sep 2024 · DOI: 10.5530/ijper.58.3.91

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ABSTRACT

Background and Objectives Selenium is considered one of the essential components of many enzymes, particularly the antioxidant enzymes such as thioredoxin reductase. Vegetables, among other food sources, are common sources of selenium. In the present study, the green synthesis of Selenium nanoparticles (SeNPs) from Ocimum basilicum’ aerial part was carried out, as were the anticancer and hepatoprotective roles of selenium nanoparticles against liver carcinogen acrylamide-induced toxicity. Materials and Methods The classification of SeNPs was done by different spectroscopic methods, including UV-spectroscopy, FT-IR, XRD, and HR-TEM. The synthesized SeNPs were tested for their anticancer properties using MTT assays (the normal human liver fibroblast cell line (WISH) and Human liver cancer (HepG2), respectively). Results The histopathological studies indicated that the liver acrylamide induced in mice showed necrosis and damage in liver cells, but the treatment of mice with SeNPs, reduced the effect of acrylamide significantly. Conclusion The results indicated the protective effect of SeNPs on acrylamide-induced cells both in vitro and in vivo.

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    Faridi, U., Zidan, N., Atteia, H., Al-Awthan, Y., Alalawy, A. I., Akhtar, M. Q., Sakran, M., & Parveen, H. (2024). Anticancer and Hepatoprotective Role of Selenium Nanoparticles against Liver Carcinogen Acrylamide Induced Toxicity: In vitro and in vivo Studies. Indian Journal of Pharmaceutical Education and Research, 58(3), 830–836. https://doi.org/10.5530/ijper.58.3.91