Volume 58, Issue 3

Review Article

1. Review

   QSAR Based Drug Repurposing: A New Paradigm in Breast Cancer Research

   Rajaram Mohapatra, Pratikeswar Panda, Sudhansu Sekhar Rout

   pp. 695–708 · DOI: 10.5530/ijper.58.3.78 · Published Jul-Sep 2024

   Breast carcinoma is the world’s most prevalent type of cancer.The building of predictive cytotoxicity breast cancer models assists permanent synthetic activities and give critical information about structure-activity of …

2. Review

   A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies

   Abdul Baquee Ahmed, Purbajit Chetia, Hemen Kalita

   pp. 709–721 · DOI: 10.5530/ijper.58.3.79 · Published Jul-Sep 2024

   Background Rheumatoid Arthritis (RA) is a chronic form of inflammatory disorder where the immune system causes the destruction of bones and cartilage in joints and impacts the quality of life. Few studies have explored t…

Original Article

1. Article

   Methodology and Results Analysis of Effect and Economic Evaluations Related to Pharmaceutical Care Practice in China: A Recent Review

   Chunyan Wei, Ruofei Li, Zhiang Wu, Guirong Xiao, Ming Hu

   pp. 722–729 · DOI: 10.5530/ijper.58.3.80 · Published Jul-Sep 2024

   Background To evaluate the value of pharmaceutical care, and sort out the existing problems in the current researches. Materials and Methods We established the research strategy and searched seven databases. Two reviewer…

2. Article

   Tablet Compression Optimization of Ivabradine Sustained-Release Tablet Using Full Factorial Design

   Kang Min Kim, Shugeng Cao, Jae Sung Pyo

   pp. 730–735 · DOI: 10.5530/ijper.58.3.81 · Published Jul-Sep 2024

   Aim This study aimed to qualitatively identify the ranges of the factors involved in the tablet compression process for ivabradine Sustained Release (SR) tablets. Materials and Methods A full factorial design of experime…

3. Article

   A Novel Targeted Nanoliposomal Atorvastatin Transdermal Patch Assisted with Solid Microneedles for Improved Bioavailability

   Sai Ramya Srikakulam, Jyothirmayee Devineni, Chandana Mokkapati, Yaswanth Venigalla, Aparna Pothuri, Anuhya Acchi, Sushil Sharma

   pp. 736–750 · DOI: 10.5530/ijper.58.3.82 · Published Jul-Sep 2024

   Objectives The present study investigated the alternate route of delivery to avoid first pass metabolism and to increase bioavailability by nanosized Liposomes (LP) with Microneedles (MNs) Assistance for the Delivery of …

4. Article

   Design and Characterization of Timolol Loaded Gellan Gum Nanoparticles for Improved Ocular Drug Delivery

   Gurpreet Kandav, Anjali Kumari Lochab, Tamanna Sharma

   pp. 751–759 · DOI: 10.5530/ijper.58.3.83 · Published Jul-Sep 2024

   Aim Glaucoma treatment often involves the topical application of Timolol maleate (TM) to the eye. However, achieving the desired bioavailability via the ocular route can be challenging due to poor retention and penetrati…

5. Article

   The Development, Formulation, and Assessment of Polyelectrolytic Complexes of an Anticancer Compound (Vinorelbine Tartarate)

   Maged Mohammed Abdo Mohsen, K. Nagasree, Amit B. Patil

   pp. 760–770 · DOI: 10.5530/ijper.58.3.84 · Published Jul-Sep 2024

   Introduction Vinorelbine tartrate is used as a first-line treatment in conjunction with conventional treatments, especially advanced disease including cancer patients. Objectives The objective of the study was to develop…

6. Article

   Fabrication of Biocompatible Transdermal Nanofibrous Patch for Localized Delivery of Lidocaine and Rosemary Oil to Improve Effective Management of Lymphoma Pain and Nursing Care

   Yanjing Guo, Ningning Li, Xingyu Chen, Tao Wang, Wenping Zhang, Lihua Wu

   pp. 771–783 · DOI: 10.5530/ijper.58.3.85 · Published Jul-Sep 2024

   Background The primary goal of the current investigation is to fabricate a transdermal NFs patch-based drug delivery system using Poly-N-Vinyl Caprolactam (PNVCL) blended with sodium alginate to prepared transdermal nano…

7. Article

   Development of Nanosponge Formulations of Rosuvastatin for Oral Delivery Using a Central Composite Design

   Sadhana Noothi, Narender Malothu, Vishnu Pulavarthy, BVS Praveen

   pp. 784–793 · DOI: 10.5530/ijper.58.3.86 · Published Jul-Sep 2024

   Background Rosuvastatin (ROS) is an anti-hyperlipidaemic drug which reduces cholesterol levels, having poor solubility and low bioavailability (<20%). The objective of the present study was to increase ROS bioavailabilit…

8. Article

   Comparison of Normal saline, Activated Charcoal and Intravenous Lipid Emulsion in a Rat Model of Colchicine Overdose: Experimental Study

   Mustafa Ferudun Çelikmen, Sezgin Sarikaya, Doğaç Niyazi Özüçelik, Fadime Canbolat, Engin Sümer, Elif Çiğdem Keleş, Deniz Sema Maktav Çelikmen

   pp. 794–801 · DOI: 10.5530/ijper.58.3.87 · Published Jul-Sep 2024

   Aim The aim of this study is to investigate the effects of Normal Saline (NS), Activated Charcoal (AC) and Intravenous Lipid Emulsion (ILE) in colchicine poisonings that resulted in death. Study Design The research is an…

9. Article

   Effects of Bifidobacterium Quadruple Viable Tablets Combined with Immune-Enhancing Enteral Nutritional Adjuvant Therapy on Intestinal Flora, Intestinal Mucosal Barrier and Immune Function in Elderly Patients with Hepatitis B Cirrhosis

   Mengmeng Xing, Chuanshun Xiao, Xiangzhong Liu Yongmei Wang

   pp. 822–829 · DOI: 10.5530/ijper.58.3.90 · Published Jul-Sep 2024

   Objectives Hepatitis B cirrhosis is a serious condition caused by the hepatitis B virus, leading to liver fibrosis and vascular proliferation. Current clinical treatments still have limitations, prompting interest in mic…

10. Article

    Plumbago indica L. Root Extract Induces Anti-proliferation, Anti-migration and Apoptosis on the Human Lung Cancer Cell Line

    Wichuda Phiphitphibunsuk, Benjaporn Buranrat

    pp. 861–869 · DOI: 10.5530/ijper.58.3.94 · Published Jul-Sep 2024

    Background Plumbago indica L. (PI) is a Thai traditional medicine that has been reported to improve health benefit including anticancer property. Nevertheless, the effects of PI and this mechanism are still less data in …

11. Article

    Protective Effect of Saikosaponin D against Streptozotocin-Induced Diabetic Nephropathy in Rats by Regulating the Oxidative Stress and Inflammatory Markers

    Yan Chen, Guanglu Zhang, Rijing Liang, Yao Shen, Xia Jiao

    pp. 882–889 · DOI: 10.5530/ijper.58.3.96 · Published Jul-Sep 2024

    Background Diabetic Nephropathy (DN) is a common problem in diabetes and is characterized by glomerular dysfunction, hyperfiltration, and ultimately kidney failure. Objectives The present study was intended to understand…

12. Article

    An Umbelliferone-induced Caspase-Mediated Apoptosis in MDA-MB-231 Breast Cancer Cells

    Mohammed Albratty, Hafiz A Makeen

    pp. 890–898 · DOI: 10.5530/ijper.58.3.97 · Published Jul-Sep 2024

    Background A highly malignant tumor, Breast Cancer (BC) has a poor prognosis for patients with the highest mortality rates in women. BC is currently treatable with a limited number of therapeutic strategies. Aim Natural …

13. Article

    Nephroprotective Activity of Marrubiin against Cisplatin-induced Nephrotoxicity in Albino Male Wistar Rats

    Guanglu Zhang, Yan Chen, Huiliu An, Nan Hao, Haitao Shi

    pp. 899–907 · DOI: 10.5530/ijper.58.3.98 · Published Jul-Sep 2024

    Background One of the most effective anti-cancer medications used to treat various cancers is Cisplatin (CP). Due to its nephrotoxicity, its usage is restricted. The purpose of this investigation is to assess Marrubiin’s…

14. Article

    Development and Validation of a Novel Second Derivative UV Method for the Estimation of Antihypertensive Drugs in Tablet Dosage Form

    Sonal Zambrekar, Leena Sawaikar, Swati Keny, Pradnya Pal, Surashree Gaude

    pp. 908–917 · DOI: 10.5530/ijper.58.3.99 · Published Jul-Sep 2024

    Aim The objective of the current work was to develop and statistically validate a second order derivative method for estimating atenolol in tablet dosage form using UV spectrophotometry. Materials and Methods The method …

15. Article

    Validated Stability Indicating HPTLC Method Development for Rivaroxaban in Tablets

    Hemlata Nimje, Mayuri Magar, Pranita Kamble, Niharika Rongali

    pp. 918–924 · DOI: 10.5530/ijper.58.3.100 · Published Jul-Sep 2024

    Objectives The present goal of this analytical study is to develop a simple, reliable, sensitive and robust method that can identify Rivaroxaban (RVB) by using high performance thin liquid chromatography. The current stu…

16. Article

    Association between Clinical Case Validation and Students’ Success Rate in Virtual Pharmacy Simulation

    Palanisamy Amirthalingam, Ahmed Mohsen Hamdan, Shahul Hameed Pakkir Mohamed, Vinoth Prabhu Veeramani, Mathar Mohideen Nagoor Thangam, Majed Falah Alanazi, Muralikrishnan Dhanasekaran, Vasudevan Mani, Saleh Fahad Alqifari, Mostafa Abdelrahman Sayed Ali

    pp. 931–939 · DOI: 10.5530/ijper.58.3.102 · Published Jul-Sep 2024

    Background Virtual simulation has been widely used in various pharmacy educational institutions worldwide, and it helps students approach the real-world pharmacy practice experience. However, the importance and practice …

17. Article

    Selection of Teaching Faculty in Pharmacy/Engineering Institutes by Using an Analytical Hierarchy Process (AHP): A Procedure Proposed

    Pankaj Sharma, Abhishek Jain, Shiv Kumar Sharma, Satyendra Kumar Sharma, Abhishek Parashar

    pp. 940–948 · DOI: 10.5530/ijper.58.3.103 · Published Jul-Sep 2024

    Background The process for choosing the right talent to further the institution’s objectives is known as faculty selection. In a pharmacy or engineering college, choosing teaching personnel is quite important. The best-q…

18. Article

    Safe and Effective Anticoagulation with Warfarin within One-year Time Period- Team Work of Healthcare Professionals

    Priti Dhande, Sushila Kawade, Akshay Chaudhari

    pp. 949–953 · DOI: 10.5530/ijper.58.3.104 · Published Jul-Sep 2024

    Background At the study site, Quality team found many incident reports of bleeding due to increased INR in patients on Warfarin anticoagulation therapy. These patients were unaware about adverse effects of anticoagulatio…

19. Article

    Evaluation of Clinical Diagnosis Effect of Intracranial Aneurysms Combined with Artificial Intelligence Assistant Diagnosis System

    Qiang Li, Chunmiao Wu, Yuhao He, Shengming Liu, Sunfu Zhang

    pp. 954–964 · DOI: 10.5530/ijper.58.3.105 · Published Jul-Sep 2024

    Objectives An intracranial aneurysm, usually referred to as an abnormal bulge in the wall of an intracranial artery, is the number one cause of subarachnoid hemorrhage and ranks third among cerebrovascular accidents afte…

20. Article

    Evaluation of Pomegranate Seed Extract as a Tyrosinase Inhibitor for Hyperpigmentation Treatment

    Veerabhuvaneshwari Veerichetty, Lawanya Sivaraman, Sabarna Jeyasaravanan, Thenujaa Dharmalingam, Hesham S. Almoallim, Hossam M. Aljawdah

    pp. 965–975 · DOI: 10.5530/ijper.58.3.106 · Published Jul-Sep 2024

    Background Melanin is a natural pigment found in various parts of the human body, which gives our skin, hair and eyes their color and protects the skin from ultraviolet light. Hyperpigmentation refers to a common skin co…

21. Article

    Synthesis and Antinociceptive Activity of 5-Amino (N-Substitutedcarboxamide)quinoline Derivatives Targeting TRPV1 Receptor

    Megha Pankaj Ambatkar, Rishabh Devendra Agade, Pramod Bhujangrao Khedekar

    pp. 976–983 · DOI: 10.5530/ijper.58.3.107 · Published Jul-Sep 2024

    Background Quinoline is a significant heterocyclic moiety involved in several biological activities including inhibition of transient receptor potential vanilloid 1. Materials and Methods A series of 5-amino( N-substitut…

22. Article

    Development and Validation of a Sensitive, Fast and Simple LC-MS/MS Method for the Quantitation of Favipiravir Pure and Tablet Dosage Forms

    Naidu Srinivasa Rao, Anil Kumar Adimulapu, M. Roja Kumari, Pallepogu Venkateswara Rao, Abbineni Anusha, Daveedu Thathapudi

    pp. 984–990 · DOI: 10.5530/ijper.58.3.108 · Published Jul-Sep 2024

    Objectives The analytical method development and validation for the determination of Favipiravir (FVPR) in pure and tablet dosage forms by LC/MS-MS Technique. Materials and Methods A simple LC-MS/MS method was developed …

23. Article

    Application of Mechanistic Pharmacokinetic Model for the Optimization of Metformin Delayed Release Dosage Form for Intestinal Targeting

    Rajkumar Malayandi, Anumol Joseph, Sideequl Akbar, Subramanian Natesan, Ravichandiran Velayutham

    pp. 991–1001 · DOI: 10.5530/ijper.58.3.109 · Published Jul-Sep 2024

    Background Metformin (MET) is a widely prescribed drug for managing Type 2 Diabetes Mellitus (T2DM). Despite the rich clinical experience and advantages, the clinical utility of MET in renal failure patients is limited b…

24. Article

    The Postgraduate Community Pharmacy Education System: Commentary on the Swiss System

    Noelia Amador-Fernández, Talitha Villien de Gabiole, David Steeb, Jérôme Berger

    pp. 1002–1006 · DOI: 10.5530/ijper.58.3.110 · Published Jul-Sep 2024

    Postgraduate education is recognized to improve communication and clinical skills and to have a positive impact on pharmacists’ professional activities and responsibilities. The purpose of this commentary is to present t…

1. Article

   Inhibiting Cancer Progression through Targeting HDAC2 with Novel Ligands: A Dynamic Insights through Virtual Screening and Simulation

   Ayyub Ali Patel, Hani Alothaid, Ayaz Khurram Mallick, Adel Ibrahim Alalawy, Rasha Tarek Mirdad, Mahmoud Tarek Mirdad, Mohammed Tarek Mirdad, Marya Ahsan, Mohammed Tarique

   pp. 802–813 · DOI: 10.5530/ijper.58.3.88 · Published Jul-Sep 2024

   Background Cancer is a multifaceted disease characterized by uncontrolled cell growth and represents a significant global health challenge. The intricate origins of cancer involve various factors that may act independent…

2. Article

   METTL14-Mediate the Biological Effects of EMT in Bladder Cancer Cells by Methylating SOX4 mRNA with m6A

   Mengliang Xie, Huantao Zhang

   pp. 814–821 · DOI: 10.5530/ijper.58.3.89 · Published Jul-Sep 2024

   Objectives Bladder Cancer (BC) is one of the most common malignant tumours of urinary system, with high rates of metastasis and mortality. Methyltransferase-like 14 (METTL14) is an RNA N6-adenosine methyltransferase that…

3. Article

   Anticancer and Hepatoprotective Role of Selenium Nanoparticles against Liver Carcinogen Acrylamide Induced Toxicity: In vitro and in vivo Studies

   Uzma Faridi, Nahla Zidan, Hebbatallah Atteia, Yahya Al-Awthan, Adel I Alalawy, Md. Qussen Akhtar, Mohamed Sakran, Humaira Parveen

   pp. 830–836 · DOI: 10.5530/ijper.58.3.91 · Published Jul-Sep 2024

   Background and Objectives Selenium is considered one of the essential components of many enzymes, particularly the antioxidant enzymes such as thioredoxin reductase. Vegetables, among other food sources, are common sourc…

4. Article

   Design and Synthesis of Novel Series of Thiophene-2, 5-dicarbohydrazide Derivatives as Potential Anticancer Agents

   Vaibhav Gawade, Vitthal Chopade

   pp. 837–853 · DOI: 10.5530/ijper.58.3.92 · Published Jul-Sep 2024

   Background The biological activity of thiophene and carbohydrazide derivatives is well known; some of them are included in various anticancer drugs. Objectives The main goal of this work was to develop effective, effecti…

5. Article

   Lithotriptic Effect of Cinnamomum verum and Nigella sativa on Ureteric Calculi

   Mrinal Sanaye, Nikhat Khan, Dinesh Dhodi, Saleha Parveen

   pp. 854–860 · DOI: 10.5530/ijper.58.3.93 · Published Jul-Sep 2024

   Introduction Urolithiasis is one of the most prevailing diseases in the society. Conventional treatments are symptomatic and are not targeted to direct the dissolution of ureteric calculi. Thus, in this study plants like…

6. Article

   Headspace SPME-GC-MS Analysis and in silico Molecular Docking Studies of Phytochemical Compounds Present in Houttuynia cordata Thunb

   Thokchom Biona, Nameirakpam Bunindro Singh, Ojit Singh Keithellakpam, Sanjai Srinivasan, Shankarrao Patil, Pulok Kumar Mukherjee, Nanaocha Sharma

   pp. 870–881 · DOI: 10.5530/ijper.58.3.95 · Published Jul-Sep 2024

   Aim The study aimed to identify the phytochemical constituents present in the leaves, stems, and roots of H. cordata and perform in silico molecular docking studies of selected common compounds present in all three parts…

Editorial

1. Forum Article

   Editorial: Embracing Innovation and Advancement in Pharmaceutical Sciences

   pp. i–ii · DOI: 10.5530/ijper.58.3.i · Published Jul-Sep 2024