Volume 58, Issue 3S

Jul-Sep 2024 · pp. s837–s847 · 38 articles

Volume: 58
Issue: 3S
Published: Jul-Sep 2024
Pages: s837–s847
Articles: 38
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Selecting an Appropriate Animal Model for Dyslipidemia
Pooja Mallya, Shaila A Lewis
pp. s683–s692 · DOI: 10.5530/ijper.58.3s.72 · Published Jul-Sep 2024
In recent years, dyslipidemia, a major risk factor for cardiovascular diseases is on the rise globally due to sedentary lifestyles and unhealthy diets. Though abundant data pertaining to the factors influencing dyslipide…
Review
A Review on the in vitro Anticancer Potentials of Acetogenins from Annona muricata Linn. a Potential Inducer of Bax-Bak and Caspase-3 Related Pathways
Pattilthodika Suhail, Velappan Venkatachalam Venkatachalam, Thirumalaisamy Balasubramanian, Parayil Varghese Christapher
pp. s693–s703 · DOI: 10.5530/ijper.58.3s.73 · Published Jul-Sep 2024
Annona muricata Linn. (A. muricata) is a tropical evergreen fruit tree belonging to Annonaceae family, also referred as graviola, soursop or corossol. The chemical compounds isolated from this plant have linked to the et…
Review
Synthesis and Pharmacological Activities of Benzothiazole Derivatives
Ravi Kant Nishad, Kunwar Abhishek Singh, Md Azizur Rahman
pp. s704–s719 · DOI: 10.5530/ijper.58.3s.74 · Published Jul-Sep 2024
The Research and Development in benzothiazole-based medicinal ingredients have turn into a hastily on the rise and gradually more lively topic. Broad number of compounds having Benzothiazole (BTZ) moiety are involved in …
Review
A field Exploration and Inventory of the Most Toxic Plants of Southern Flora Tunisian
Ouederni Ahmed Ridha El, Rania Omrani, Nour El Ouederni, Yasmine El Ouederni, Aida Katar, Noureddine Amdouni, Abderrazak Hedhili
pp. s720–s731 · DOI: 10.5530/ijper.58.3s.75 · Published Jul-Sep 2024
In the present work, a bibliographical survey of the toxicity of some plants of the southern Tunisia’s flora was conducted on several methanoic extracts from miscellaneous toxic plants of the southern Tunisian flora and …
Review
A Phytochemicals Approach towards the Role of Dioxins in Disease Progression Targeting Various Pathways: Insights
Saba Beigh
pp. s732–s756 · DOI: 10.5530/ijper.58.3s.76 · Published Jul-Sep 2024
Introduction Dioxins represent a category of enduring environmental contaminants that possess the capability to elicit endocrine disruptions and a spectrum of ailments, most notably encompassing malignancies, immunologic…
Review
Aquasome: As Drug Delivery Carrier in the Pharmaceutical Field
Varsha Sahu, Sunit Kumar Sahoo, Amaresh Chandra Sahoo
pp. s757–s767 · DOI: 10.5530/ijper.58.3s.77 · Published Jul-Sep 2024
In the pharmaceutical field, various diagnostic tools and delivery systems are available which used for the identification of diseases and treatment. Aquasome is a new type of vesicular drug delivery system. It is a self…
Review
The Revolutionary Role of Artificial Intelligence (AI) in Pharmaceutical Sciences
Amaresh Prusty, Susanta Kumar Panda
pp. s757–s767 · DOI: 10.5530/ijper.58.3s.78 · Published Jul-Sep 2024
The traditional drug discovery process is expensive, time-consuming, and often leads to a high failure rate. The development of numerous new medications in the pharmaceutical sciences is only one example of how the advan…

Original Article

Article
Low Dose Lipopolysaccharide-Induced Depressive-Like Phenotype is Mediated by Proinflammatory Cytokines in Mice and Role of Ketamine
Shuvranshu Praharaj, Vandurayanpet Kaliyamoorthy Kalaichelvan, Vedigounder Murugan, Velappan Venkatachalam, Ishtiyaque Ahmad
pp. s777–s786 · DOI: 10.5530/ijper.58.3s.79 · Published Jul-Sep 2024
Background Depression is a common mental illness, with an estimated 3.8% of global population affected. In the pathophysiology of depression, ketamine acts quickly in patients. Treatment with low-dose ketamine upon admin…
Article
Interstitial Lung Diseases Classification in the Context of Pharmaceutical Education and Research: A Two-Level Deep Learning Approach
Vanita Dnyandev Jadhav, Lalit Vasantrao Patil
pp. s787–s795 · DOI: 10.5530/ijper.58.3s.80 · Published Jul-Sep 2024
Aim/Background In this work, a novel method for improving the quality of healthcare in the diagnosis of Interstitial Lung Disease (ILD) using High-Resolution Computed Tomography (HRCT) images is proposed. Materials and M…
Article
Computational Study and Evaluation of Lidocaine and Nitroglycerin Ointment for External Hemorrhoid Treatment
Arwa Alshargabi, Wafa Mohammed Al-Madhagi, Abdulkarim Kassem Alzomor
pp. s796–s804 · DOI: 10.5530/ijper.58.3s.81 · Published Jul-Sep 2024
Background and Objectives Hemorrhoids are defined as swollen veins in the anus and lower rectum. Hemorrhoids are a common medical problem and have a negative impact on people’s lives. The drugs that are available on the …
Article
Smart Manipulated UV Spectroscopic Methods for Resolving the Overlapped Spectra for Quality Control of Two Analgesic Binary Combination Formulations
Mahesh Attimarad, Bandar Aldhubiab, Sreeharsha Nagaraja, Shinu Pottathil
pp. s796–s804 · DOI: 10.5530/ijper.58.3s.82 · Published Jul-Sep 2024
Background The combination of two drugs celecoxib + tramadol and diclofenac sodium + tramadol with different mechanisms of action is better for achieving effective pain control. Materials and Methods The simple reproduci…
Article
Study of the Effect of Magnetic Serum Albumin Nanoparticles on Cultured Mice Renal Mesangial Cells and Submandibular Cells Using Different Biological Assays
Naif Al Qurashi
pp. s815–s827 · DOI: 10.5530/ijper.58.3s.83 · Published Jul-Sep 2024
Background Bovine Albumin Nanoparticles (BAN) have a high magnetic susceptibility and great potential for biomedical applications. Aim Evaluate the in vitro effects of magnetic BAN on mouse renal and submandibular cells.…
Article
QBD-Powered Design and Optimization of Nanostructured Lipid Carriers Loaded with BCS class IV Anticancer Drug
Pamujula Naga Haritha, Kunchithapatham Janakiraman, Katla Venu Madhav, Padavala Sunil Kumar Chaitanya
pp. s815–s827 · DOI: 10.5530/ijper.58.3s.84 · Published Jul-Sep 2024
Background The therapeutic efficacy of an active Pharmaceutical ingredient depends on its solubility in body fluids. The low bioavailability of nearly 90% of new active Pharmaceutical ingredients and 40% of the existing …
Article
Development of Colon Targeted Extended Drug Delivery System for Mebendazole Using Grafted Natural Polymers
Baburao Nanasaheb Chandakavathe, Ravindra Kulkarni, Akash Dadanna Rajmane, Snehal Limbraj Mane, Nishigandha Jayant Waykule
pp. s837–s847 · DOI: 10.5530/ijper.58.3s.85 · Published Jul-Sep 2024
Background Even though the natural polymers are biodegradable, non-toxic and cost effective, but these suffer with some of drawbacks like uncontrolled drug release, enzymatic degradation, reduction in viscosity on long t…
Article
Development and Evaluation of Gastroretentive Bioadhesive Tablet of Atenolol Using a Naturally Occurring Biodegradable Polymer
Soji Soman, Aysha Padinhar Basheer, Geethu Mol, Luthfa Ahamed Muneer, Mariyammath Rafeeqa Khazi Abdul Rahiman, Gasper Fernandes, Srinivas Mutalik
pp. s848–s860 · DOI: 10.5530/ijper.58.3s.86 · Published Jul-Sep 2024
Aim Using atenolol as a model active pharmaceutical and galactomannan from the seeds of Trigonella foenumgraecum as a mucoadhesive polymer, an effort was made to develop a gastroretentive bioadhesive floating delivery sy…
Article
Design and Development of Rebamipide Solid Dispersion-Loaded Floating Beads for Ameliorated Therapeutics
Poonam Sharma, Chitra Kaundal, Shweta Agarwal
pp. s861–s871 · DOI: 10.5530/ijper.58.3s.87 · Published Jul-Sep 2024
Objectives Rebamipide, a gastroprotective drug, is used for preventing and treating ulcers but it has low aqueous solubility leading to poor bioavailability (10%). It acts both locally and systemically to provide gastrop…
Article
Formulation of Sustained-Release Tablets of Tolperisone HCl Using Different Blends of Hydrophilic and Hydrophobic Polymers
Mansi Butola, Ashutosh Badola, Nidhi Nainwal, Shilpa Rana, Vikash Jakhmola, Yogita Ale, Arif N. M. Ansori
pp. s872–s879 · DOI: 10.5530/ijper.58.3s.88 · Published Jul-Sep 2024
Background Tolperisone Hydrochloride (HCl) is a muscle relaxant that relaxes muscles by acting on the Central Nervous System (CNS). It acts at the spinal cord level by blocking calcium and sodium channels. It primarily i…
Article
Formulation and Evaluation of Fast Dissolving Tablets of Oxcarbazepine Using Liquisolid Technology
Bindhu Booraguntae Mohana, Eswar Gupta Maddi, Raman Dang
pp. s880–s889 · DOI: 10.5530/ijper.58.3s.89 · Published Jul-Sep 2024
Background/Aim The aim of the study was to improve the dissolution profiles of Oxcarbazepine (OXC) from its tablets. This study was done to evaluate the effects of different formulation variables, i.e. type of non-volati…
Article
Characterizations of the Secondary Metabolites of the Sea Squirt Diplosoma listerianum Milne-Edwards, 1841) (Ascidiacea, Enterogona) and its Associated Micro-organisms
Naif Al Qurashi
pp. s890–s899 · DOI: 10.5530/ijper.58.3s.90 · Published Jul-Sep 2024
Background The biochemistry of secondary metabolites of marine origin has been identified as a promising area for obtaining new and potent pharmaceutical agents. These secondary metabolism molecules may have important fu…
Article
Reserpine Induces Apoptosis in Drug-Resistant Cancer through Modulating STAT3 and NF-κB Signaling
Sumathi Raguraman, Hesham S Almoallim, Tahani Awad Alahmadi, Samer Hasan Hussein-Al-Ali, Muruganantham Bharathi, Arun Kumar Ramu
pp. s900–s909 · DOI: 10.5530/ijper.58.3s.91 · Published Jul-Sep 2024
Introduction A major feature of drug-resistant cancer is the overexpression of transcription factors. During the study, reserpine, an indole alkaloid, was examined for its anticancer effects on cancer with drug resistanc…
Article
Optimization and Characterization of Lamivudine-Loaded TCS-PEG/MMT Polymeric Nanocomposites for Enhanced Antiretroviral Therapy
Girish Meravanige, Lakshmi Radhika Gajula, Asha Bhuvanahalli Rangappa, Prakash Goudanavar, Srikruthi Kunigal Sridhar, Nimbagal Raghavendra Naveen, Nagaraja Sreeharsha, Predeepkumar Narayanappa Shiroorkar, Afzal Haq Asif, Mallikarjun Telsang
pp. s910–s924 · DOI: 10.5530/ijper.58.3s.92 · Published Jul-Sep 2024
Background Acquired Immunodeficiency Syndrome (AIDS), caused by the Human Immunodeficiency Virus (HIV) was initially associated with rapid disease progression and high mortality rates. However, advances in drug delivery …
Article
Assessment of Anti-Alzheimer Characterization of Green Synthesized Zinc Nanoparticles Containing Extract of Cordyceps militaris
Khyati Saini, Satish Shilpi, Swati Arya, Jagannath Sahoo
pp. s925–s933 · DOI: 10.5530/ijper.58.3s.93 · Published Jul-Sep 2024
Background In current research, Zinc Nanoparticles (ZnNPs) were synthesized using green synthesis technology. It is the best method which is eco-friendly and cost-effective. The extract of fungus Cordyceps militaris was …
Article
Optimization of Anti-Inflammatory Activity of Rauvolfia tetraphylla L. Crude Extracts Using Response Surface Methodology
Lavanya Nallasamy, Amutha Swaminathan, Deepika Krishnamoorthy, Girija Sangari Murugavelu, Swarna Lakshmi Selvaraj
pp. s934–s943 · DOI: 10.5530/ijper.58.3s.94 · Published Jul-Sep 2024
Background The background of this study revolves around Rauvolfia tetraphylla and its potential anti-inflammatory properties. To explore the anti-inflammatory activity of crude extracts obtained from the leaf and fruit o…
Article
Biosynthesis of Silver Nanoparticles from Canavalia rosea and its Antiproliferative Effect on MCF-7 Cancer Cell Line
R Vasanthi, V Balamurugan, Hesham S. Almoallim, Sulaiman Ali Alharbi
pp. s944–s962 · DOI: 10.5530/ijper.58.3s.95 · Published Jul-Sep 2024
Aim The generation of silver nanoparticles via a green synthesis approach with leaf and stem extracts of Canavalia rosea is our prime objective. Materials and Methods The fabricated Nanoparticles (AgNPs) are interpreted …
Article
Metal Complexes of Curcumin: A Comprehensive Approach to Design, Synthesis, Characterization and Assessment of Anti-tubercular Activity
Paramita Das, HM Yamuna, M Harshashree, Raman Dang
pp. s963–s972 · DOI: 10.5530/ijper.58.3s.96 · Published Jul-Sep 2024
Background The primary challenge facing Tuberculosis (TB) is the growing prevalence of drug resistance and the hepatotoxicity secondary effects of first and second-line anti-TB treatments have reignited interest in explo…
Article
Scrutinizing Potential Phytoconstituents from Bauhinia variegata in Mitigating the Symptoms of Polycystic Ovarian Syndrome: A Computational Approach
Pavithra Lakshmi Narayanan, Chitra Vellapandian
pp. s973–s985 · DOI: 10.5530/ijper.58.3s.97 · Published Jul-Sep 2024
Background Polycystic ovarian syndrome is a metabolic disorder majorly caused by the hormonal fluctuations in female and the current scenario explains that adolescents remain predominantly affected with this disorder. Ba…
Article
Ethanolic Extract of Equisetum arvense: A Potential Agent against Rheumatoid Arthritis in Wistar Rats with Freund’s Complete Adjuvant-Induced Arthritis
Franco Gohain, Jyothi Yachamaneni, Prasanthi Kallepalli, Nishanth Ramesh, Mayukh Sarkar, Syed Sohaila, Raman Dang
pp. s986–s9994 · DOI: 10.5530/ijper.58.3s.98 · Published Jul-Sep 2024
Background Rheumatoid arthritis, a global autoimmune affliction affecting 0.3-1% of the population, is characterized by chronic inflammation and systemic symptoms. Dissatisfaction with conventional treatments leads indiv…
Article
Green Synthesis of Silver Nano Particles Structural Characterization and their Antioxidant and Anticancer Potential Using Adenocarcinoma (A549) Cell Line
Shaik Sadik, Vasia, Arnab Kumar Maiti, Basvaraj A Shivapooji, Sandipan Jana
pp. s995–s1007 · DOI: 10.5530/ijper.58.3s.99 · Published Jul-Sep 2024
Background Over the past two decades, Silver Nanoparticles (AgNPs) have demonstrated a wide range of antioxidant and anticancer properties. Vinca alkaloid exhibits the anticancer efficacy by direct metaphase arrest of ce…
Article
Exploring the Phytoconstituents, Differential Pharmacology, and Interaction with Empagliflozin of Olea europaea Leaves Extracts
Zinah Kadhim Saeed, Ali Mahmoud Al-Samydai, Moath Alqaraleh, Nidal Adel Qinna, Bayan Yousef Ghanim, Amal Mayyas, Deniz Al-Tawalbeh, Shrouq Taiseer Alsotari, Walhan Alshaer, Farah Al-Mamoori, Lidia Kamal Al-Halaseh
pp. s1008–s1017 · DOI: 10.5530/ijper.58.3s.100 · Published Jul-Sep 2024
Background The Olea europaea L. leaves have long been used in treating various illnesses. Its pharmacological activity based on the phytoactive constituents; therefore, optimizing the extraction process should intensify …
Article
Quality Control of Hydrochlorothiazide Pharmaceuticals
Dessislava Vladimirova Ilieva-Tonova, Lily Antonova Andonova, Ivanka Petkova Pencheva-El Tibi
pp. s1018–s1027 · DOI: 10.5530/ijper.58.3s.101 · Published Jul-Sep 2024
Background One of the organisational strategies to ensure the use of relevant good practises for each stage in the life cycle of pharmaceutical products is the market surveillance program, which aims to demonstrate produ…
Article
Method Development and Validation for the Quantification of Abametapir in Biological Matrices by LC-ESI-MS/MS
Vinayaga Sundaram Krishnan, Darna Bhikshapathi, Shankar Cheruku
pp. s1028–s1033 · DOI: 10.5530/ijper.58.3s.102 · Published Jul-Sep 2024
Aim A precise, linear and specific liquid chromatography-tandem mass spectrometry procedure was executed and subjected for validation for the quantification of plasma. Materials and Methods The chromatography elution was…
Article
Simultaneous Quantification of Famotidine and PABA by First Order Derivative Spectral Technique of UV Spectrophotometric from FMT-PABA Cocrystals
Parth Sarathi, Swarupanjali Padhi
pp. s1034–s1040 · DOI: 10.5530/ijper.58.3s.103 · Published Jul-Sep 2024
Objectives The investigation article intends is to build and validate a more convenient scientific approach to accurately simultaneously determine famotidine and para-amino benzoic acid from their cocrystals Significance…
Article
A Rapid UPLC Technique for Quantification of Tegafur, Oteracil and Gimeracil in Bulk and Pharmaceuticals and its Validation
Charumathi Salva, Rajitha Galla
pp. s1041–s1052 · DOI: 10.5530/ijper.58.3s.104 · Published Jul-Sep 2024
Background Tegafur (TEG) is a prodrug of 5-Fluorouracil (FU) that is mainly employed in the treatment of colorectal tumors combined with Gimeracil (GIM) and Oteracil (OTE) enhances its stability by enhancing the antineop…
Article
Method Development and Validation of Antihypertensive Drugs Using HPLC Technique
M.K Ranganath, P D Chaithanya Sudha, G Ramesh, T Abishek, V Baskaran, R Hariesh Kumar, Raman Dang
pp. s1053–s1061 · DOI: 10.5530/ijper.58.3s.105 · Published Jul-Sep 2024
Aim A validated RP-HPLC method was established for the quantification of Amlodipine and Metoprolol succinate according to ICH guidelines. Materials and Methods This method utilized a Phenomenex (US) C18 column with dimen…
Article
Design, Synthesis, Molecular Docking, in silico ADME Assessment of Pyrrole-Based Heterocyclic Amino Acid Derivatives as Potential Anticonvulsant Agent
Md Shamsher Alam, Mohammed Albratty, Hassan Ahmed Alhazmi, Asim Najmi, Khalid Zoghebi, Hafiz Antar Makeen, Safaa Fathy Saleh, Ahmed Farag El Kirdasy, Benson Mathai Kochikuzhyil
pp. s1062–s1074 · DOI: 10.5530/ijper.58.3s.106 · Published Jul-Sep 2024
Background Epilepsy is a neurological disorder characterized by anomalous brain activity, convulsionsandoddbehaviour.Tenpyrrolecarbohydratebasedanalogues(Va-Vj)weresynthesized with amide as intermediate in the current re…
Article
Synthesis, Therapeutic Potential, Quantum Studies and Molecular Properties of Amino Acid Fused 1,3,4-Oxadiazole Derivatives as an Unnatural Amino Acids
Ajay Singh Bisht, Divya Juyal
pp. s1075–s1082 · DOI: 10.5530/ijper.58.3s.107 · Published Jul-Sep 2024
Background In present study 1,3,4-oxadiazole derivatives with iso-sterically fused amino acids was attempted to synthesize. As variety of chemical reactions that 1, 3 and 4-oxadiazole molecules can experience, it made th…
Article
Design of Lamivudine Loaded Metal Organic Frameworks MIL 100 (Fe) by Microwave Assisted Chemistry
Palagati Sucharitha, Ramesh Reddy, Irivichetty Jahnavi, Hanumanthappagari Prakruthi, Thalla Sruthi, Mulinti Rajashekhar Gari Bhuthe Gowd, Bogala Haseena, Niranjan Babu
pp. s1083–s1092 · DOI: 10.5530/ijper.58.3s.108 · Published Jul-Sep 2024
Background Lamivudine is an Anti-Viral Drug belongs to BCS Class II Drug which exhibits limited solubility and high permeability through oral route. Aim The study was designed to predict the solubility potential of Lamiv…
Article
Prospective Observational Study of Adverse Drug Reactions of Anti-HER2 and Microtubule Damaging Drugs Used in Cancer Treatment in a Tertiary Care Hospital
Lakshmi Prasannah, Sathish, Sumi Lowrance
pp. s1093–s1101 · DOI: 10.5530/ijper.58.3s.109 · Published Jul-Sep 2024
Background Cancer treatment has witnessed remarkable advancements with the development of targeted therapies, such as anti-HER2 agents and microtubule-damaging drugs. Despite their efficacy, these drugs can be associated…