Volume 58, Issue 4

Oct-Dec 2024 · pp. 1007–1379 · 36 articles

Volume: 58
Issue: 4
Published: Oct-Dec 2024
Pages: 1007–1379
Articles: 36
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Efficacy and Safety of Erythromycin in the Treatment of Mycoplasma Pneumonia in Children: A Systematic Review and Meta-Analysis
Mingxiu Sun, Zhirui Xue, Jiarui Li, Likun Du
pp. 1007–1014 · DOI: 10.5530/ijper.58.4.113 · Published Oct-Dec 2024
Aim The effectiveness and safety of erythromycin for treating mycoplasma pneumonia in pediatric patients is a subject of significant interest. This study aims to conduct a systematic review and meta-analysis to assess th…
Review
From Risk to Resilience: Uncovering Drug Recall Trends and Bolstering Safety Strategies
Venkateswara Raju Kalidindi, Bandaru Mani Sai Durga, Lakshmi Prasanthi Nori
pp. 1015–1033 · DOI: 10.5530/ijper.58.4.114 · Published Oct-Dec 2024
The process of officially calling something back to its original or initial location is termed as “recall.” Pharmaceutical recalls involve requesting to get back a product after it leaves the manufacturer to reach the di…
Review
Plant Bioactive Compounds: Crucial Pharmacological Properties and Role of Elicitors in Enhancing Production
Durga Anusha Sampath Kumar, Deepa Sankar Parasurama
pp. 1034–1044 · DOI: 10.5530/ijper.58.4.115 · Published Oct-Dec 2024
Plant secondary metabolites play a vital role in developing numerous industrial products. Nutritive products developed from natural sources have better acceptance and demand than chemically synthesized products. Biologic…
Review
Standards of Child Resistant Packaging: A Regulatory View
Gowthami Kodlahalli Ravindra, Bhoopathi Subramaniam, Balamuralidhara Veeranna
pp. 1045–1053 · DOI: 10.5530/ijper.58.4.116 · Published Oct-Dec 2024
Aim Special packaging known as “child-resistant packaging” is intended to minimize the possibility of kids eating harmful substances. The Poison Prevention Packaging Act of 1970 confers jurisdiction to regulate this on t…
Review
Research Progress in Mechanisms of Drug-Resistance of Macrolide Antibiotics Resistance in Mycoplasma pneumoniae
Meixuan Jia, Qingtao Li, Lijun Zhang, Xiaona Qian, Liyuan Tian, Zhihui Yan
pp. 1054–1069 · DOI: 10.5530/ijper.58.4.117 · Published Oct-Dec 2024
Aim/Background This review aims to enhance understanding of Mycoplasma pneumoniae (MP) infection and Macrolide-Resistant Mycoplasma pneumoniae (MRMP) pneumonia, emphasizing their epidemiological characteristics and resis…
Review
Antibacterial Effects of Bioactive Boswellic Acids Loaded Chitosan Nanoparticles against Gram-Positive and Gram-Negative Bacteria
Neeta Rathi, Satyender Kumar, Seema, Harish Dureja
pp. 1189–1197 · DOI: 10.5530/ijper.58.4.131 · Published Oct-Dec 2024
Background: Boswellic acids are naturally occurring pentacyclic terpenoids that have revealed valuable anti-inflammatory, antiproliferation and anticancerous activities. Instead of these effects boswellic acids also poss…
Review
Development and Characterization of Liquisolid Compact to Improve Dissolution of an Antihypertensive Drug
Arvinder Kaur, Sachin Verma, Deepa Bagur Paramesh, Nawaz Mahammad
pp. 1198–1204 · DOI: 10.5530/ijper.58.4.132 · Published Oct-Dec 2024
Background: The goal of the current research was to use the straight forward, scalable, and economical Liquisolid compact to improve the dissolution profile of the poorly soluble medication Ramipril. Objectives: Utilisin…
Review
Design, Optimization, and in vitro Evaluation of Orally Disintegrating Tablets Containing Amlodipine Besylate
Sevinç Şahbaz, Setenay Özer-Önder, Timuçin Uğurlu
pp. 1205–1214 · DOI: 10.5530/ijper.58.4.133 · Published Oct-Dec 2024
Background: In this study, it was aimed to prepare orally disintegrating tablet formulations of amlodipine besylate by applying the experimental design. Materials and Methods: A face-centered, central composite 32 full f…
Review
Formulation of Pregabalin-Loaded Trimethyl Chitosan Microspheres for Nasal Drug Delivery: In vitro, ex vivo and in vivo Characterization
Sonwane Priyanka, Qutub Mohammad, Umekar Milind, Taksande Jayshree
pp. 1215–1224 · DOI: 10.5530/ijper.58.4.134 · Published Oct-Dec 2024
Background: Polar drugs make it difficult to cross nasal cells. Trimethyl Chitosan (TMC) microspheres help absorption by opening junctions, increasing drug retention. Pregabalin absorbs well orally but delays crossing th…
Review
Synthesis, Anti-inflammatory and in silico Studies of few novel 1,2,4-Triazole Derived Schiff Base Compounds
Deepanshu Vishwakarma, Surya Prakash Gupta
pp. 1235–1241 · DOI: 10.5530/ijper.58.4.136 · Published Oct-Dec 2024
Background: Every year more than 1 billion prescriptions are written for all NSAIDs and yet the quest to develop new NSAIDs remains prominent. Objectives: The current investigation's goal was to synthesize and assess the…
Review
Coumarin-1,2,3-Triazole Hybrids as Promising Antibacterial Agents: In silico Molecular Docking, ADMET and Molecular Dynamics Simulation Studies (Exploring in silico Antibacterial Potential of Coumarin-1,2,3-triazoles)
Krishna Narayan Mishra, Mayank Rashmi, Harish Chandra Upadhyay
pp. 1242–1254 · DOI: 10.5530/ijper.58.4.137 · Published Oct-Dec 2024
Background: A lot of coumarin-1,2,3-triazole hybrids have been reported to show antibacterial activities, but most of them are unexplored in clinical studies. Herein, we wish to apply in silico docking, physiochemical pr…
Review
A Simultaneous Quantification of Four Potential Genotoxic Impurities Purinediol Hydrochloride, N7-Isomer, Monoalkyl Contaminant and Diacetyl Purine Present in Penciclovir Using LC-MS/MS
Nagasurendra Reddy Varampati, Devanna Nayakanti
pp. 1255–1266 · DOI: 10.5530/ijper.58.4.138 · Published Oct-Dec 2024
Background: Penciclovir is a medication for antiviral therapy for curing different kinds of herpes virus infections. The four contaminants are the starting materials of Penciclovir which are present at a trace level in t…
Review
Electrometric Study on Nature and Stability of CoII, NiII and CuII Complexes with 5-Sulfosalicylic Acid in DMSO-Water Mixtures
Malla Balakrishna
pp. 1267–1276 · DOI: 10.5530/ijper.58.4.139 · Published Oct-Dec 2024
Background: The bioavailability of an element and its toxicity based on its chemical species. According to IUPAC the concept of chemical speciation is defined as it is a form of an element according to its oxidation stat…
Review
HR-LCMS Metabolite Profiling and in silico Evaluation of the Antidiabetic Activity of Methanolic Leaf Extract of Chrozophora rottleri (Geiseler) A. Juss. Ex Spreng.
Srilakshmi Nallapaty, Narender Malothu, Sathish Kumar Konidala, Anka Rao Areti, Chakravarthi Guntupalli
pp. 1277–1286 · DOI: 10.5530/ijper.58.4.140 · Published Oct-Dec 2024
Background: Chrozophora rottleri (Geiseler) A. Juss. ex Spreng. is a well-known traditional medicinal plant with a complex biological profile, though inadequate research has been established on its possible anti-diabetic…
Review
GCMS and LCMS/MS Based Analysis for the Identification and Characterization of Bioactive Metabolites of Seaweed Kappaphycus striatus as an Anti-hypertensive and Anti-hypercholesterolemic Agent
Hannis Fadzillah Mohsin, Zolkapli Eshak, Sadia Sultan, Wasim Ahmad, Mohammad Humayoon Amini, Kamran Ashraf
pp. 1287–1298 · DOI: 10.5530/ijper.58.4.141 · Published Oct-Dec 2024
Background: Over 50% of the population in Malaysia has hypercholesterolemia, which puts them at a high risk of cardiovascular disease. Both food sources and the ingredients in traditional medications are essential to the…
Review
Development and Validation of a New RP-HPLC Method for the Simultaneous Estimation of Nirmatrelvir, Ritonavir and Molnupiravir in Formulated Nanosponges, Plasma Samples and its Pharmacokinetic Study
Vyshali Veerareddy, Kumaraswamy Gandla
pp. 1299–1310 · DOI: 10.5530/ijper.58.4.142 · Published Oct-Dec 2024
Background: Nirmatrelvir and Ritonavir are used in combination (Paxlovid®) in order to treat COVID-19. Thus, the goal of the current study was to create an easy-to-use, accurate, and sensitive method for the preparation …
Review
A Cross-Sectional Study of Community Attitude towards Herbal Products against Hepatobiliary Diseases in Northern Cyprus
Umut Sõzüõz, Azmi Hanoğlu, Fehmi Burak Alkaş, Duygu Yiğit Hanoğlu, Ali Hikmet Meriçli, Dudu Őzkum Yavuz
pp. 1311–1317 · DOI: 10.5530/ijper.58.4.112 · Published Oct-Dec 2024
Aim: The study in Northern Cyprus aimed to improve patient-centered care and healthcare practices by examining community perceptions of Herbal Products (HPs) for liver and biliary diseases. Materials and Methods: The sel…
Review
Evaluation of the Knowledge, Opinion, and Approaches of Pharmacists, Physicians, Dieticians, and the Public on Herbal Products Used for Weight Control and Slimming in Northern Cyprus
Bariş Şendal lzzet, Hasan Ulaş Yavuz, Dudu Özkum Yavuz
pp. 1318–1327 · DOI: 10.5530/ijper.58.4.111 · Published Oct-Dec 2024
Background: This study explores the perspectives of Northern Cyprus (NC) pharmacists, physicians, dieticians, and the public regarding Herbal Products (HP) for Weight Control (WC) and slimming, contributing valuable insi…
Review
A Prospective Observational Study on Assessment of Risk Factors, Complications and Clinical Efficacy of Hepatoprotectives and Antimicrobials in Treatment of Liver Diseases at Tertiary Care Teaching Hospital in Telangana
Jaya Sollu, Mounika Pulusu, Deepthi Peddaramamolla, Jharna Islam, Nikhil Soma, Chinnaeswaraiah Maram
pp. 1328–1335 · DOI: 10.5530/ijper.58.4.143 · Published Oct-Dec 2024
Background: The liver serves a variety of essential purposes, making it the most important organ. Chronic liver disease (CLD) has a wide range of etiologies, including toxins, alcoholism, infections, autoimmune illnesses…
Review
Augmented Optical Retention and Improved Antibacterial Activity against Conjunctivitis of Moxifloxacin Hydrochloride Entrapped in Microsponges in situ Gel: Formulation Evaluation and in vivo Remedial Value in Rabbits
Sangeet Kumar Sharma, Ishab Kumar, Ankur Rohilla, Ramchander Khatri, Tanuj Hooda, Seema Rohilla
pp. 1336–1347 · DOI: u10.5530/ijper.58.4.144 · Published Oct-Dec 2024
Objectives: Moxifloxacin hydrochloride is an antibiotic related to flouroquinolones class. It possessed reasonable to exceptional efficacy against gram-negative ocular pathogens. The prime goal of this study was to formu…
Review
Silencing PDCD4 Mediates TFEB Overexpression Promoting Proliferation, Migration and Invasion of Cervical Cancer HeLa Cells
Xing Gao, Ziying Liang, Yanan Yuan, Wenbo Liu
pp. 1348–1355 · DOI: 10.5530/ijper.58.4.145 · Published Oct-Dec 2024
Aim/Background: Cervical cancer is a common gynecologic malignant tumor, its occurrence and development are related to genetic and environmental factors. Recent studies have shown that Programmed Cell Death 4 (PDCD4) and…
Review
Strategic Targeting of Plasmodium Dihydroorotate Dehydrogenase through Antimicrobial Artemisinin Chiral Centers and their Derivatives: An Integrative Study Using Network Pharmacology and Isothermal Titration Calorimetry
Zia ur Rehman
pp. 1356–1372 · DOI: 10.5530/ijper.58.4.146 · Published Oct-Dec 2024
Background: Developing effective antimalarial medications requires understanding the interactions between Plasmodium Dihydroorotate dehydrogenase (DHOdehase) and Artemisinin, including its fourteen stereoisomers (R/S) wh…

Original Article

Article
Rutaecarpine Induces Apoptosis via a Mitochondrial Membrane-Mediated Pathway in the Human Liver Cancer Cells (HepG2)
Xiaoyuan Zhuang, Yatian Wang, Shen Lin, Guoshan Zhang
pp. 1070–1076 · DOI: 10.5530/ijper.58.4.118 · Published Oct-Dec 2024
Background The desire for novel drugs and bioactive ingredients to combat serious illnesses like cancer has grown dramatically. A great deal of research is being done to discover and create new medications. Aim According…
Article
The Therapeutic Effects of QihaPingchuan Capsule in Combination with Triple Therapy (ICS+LABA+LAMA) on Chronic Obstructive Pulmonary Disease
Zhijun Dong, Shujiang Dong, Jiang Li, Yanli Zhu, Zhiyong Ma, Yupei Hou, Weidong Zhao
pp. 1077–1083 · DOI: 10.5530/ijper.58.4.119 · Published Jul-Sep 2024
Objectives To explore the curative effect of QihaPingchuan Capsule combined with triple therapy [Inhaled Corticosteroid (ICS)+Long-Acting β2 receptor Agonist (LABA)+Long-Acting Anticholinergic drug (LAMA)] on Chronic Obs…
Article
Unveiling Ethical AI: An In-Depth Bibliometric and Visual Exploration
Qihui Yuan, Tingxuan Chen, Qing Yang, Zongming Zhang
pp. 1084–1101 · DOI: 10.5530/ijper.58.4.120 · Published Jul-Sep 2024
This study meticulously delineates the research progression, focal points, developmental path and emergent evolutionary trajectories of computational intelligence within the domain of ethics. A comprehensive quantitative…
Article
Berberine’s Therapeutic Prospects in Parkinson’s Disease: A Spotlight on Cholesterol Regulation for Cognitive Improvement
T Lakshmi Narayanan, Dithu Thekkekkara, Manasa Renu Srivalli Chattu, Amrita Babu, Sreenivasulu Naidu Kondaveeti, SK. Meheroonisha, Thummuru Ekshita Sai
pp. 1102–1109 · DOI: 10.5530/ijper.58.4.121 · Published Jul-Sep 2024
Background Cholesterol synthesized in astrocytes of the cerebrum plays a pivotal role in regulating hippocampal neurogenesis and cognitive function. Dysregulation of cholesterol metabolism has emerged as a key contributo…
Article
Shikimate Kinase 1 from Klebsiella pneumoniae as a New Drug Target Enzyme: Insights from Comparative Modeling and Molecular Dynamics
Yanping Li, Suresh Kumar, Lihu Zhang
pp. 1110–1120 · DOI: 10.5530/ijper.58.4.122 · Published Jul-Sep 2024
Background Klebsiella pneumoniae, a Gram-negative bacterium, is an established nosocomial pathogen that is particularly dangerous to immunosuppressed individuals, causing diseases such as sepsis, pneumonia, urinary tract…
Article
Unveiling Betulinic Acid as a Potent CDK4 Inhibitor for Cancer Therapeutics
Basiouny El-Gamal, Thoraya A-Elgadir, Ayyub Ali Patel, Mohamed Abd Ellatif, Khalid Ali Nasif, Awad Saeed Alsamghan, Arshi Malik, Mohamed Babiker Abd Elrouf, Imad Alghawanmeh, Marwa Saeed, Osama Haroun Ahmed, Soha Makki, Haitham Elshaikh, Yasser Ali
pp. 1117–1129 · DOI: 10.5530/ijper.58.4.123 · Published Jul-Sep 2024
Background CDK4 play a pivotal role in cell cycle regulation, making it a critical players in the development and progression of cancer. In recent years, there has been a growing interest in targeting CDK4 for cancer the…
Article
Evaluation of the Combinatory Anti-Depressant Approach of Metformin and Quercetin in Mice Exposed to Chronic Unpredictable Mild Stress Behavorial Alteration
Mikhil Santosh Kore, Angel Pavalu Godad, Gaurav Mahesh Doshi
pp. 1130–1138 · DOI: 10.5530/ijper.58.4.124 · Published Jul-Sep 2024
Background To develop a new drug approach, it is necessary to understand possible ways by which suppression of depressive symptoms can be achieved at the biochemical level. One such protein, which can help relieve depres…
Article
Leonurine Attenuates Streptozotocin-Induced Diabetic Nephropathy in Rats by Mitigating Dyslipidemia and Inflammation
Lin Li, Qian Wang, Yan Gao, Li Zhang
pp. 1139–1147 · DOI: 10.5530/ijper.58.4.125 · Published Oct-Dec 2024
Background Diabetic Nephropathy (DN) is one of the serious complications associated with a prolonged diabetic condition. DN continues to be the primary cause of morbidity and mortality among diabetic patients globally. O…
Article
Preclinical Studies of Euphorbia lactea Aerial Extract on Atherogenic-Diet-Induced Atherosclerosis
Zubair Khan, Nazia Siddiqui, Garima Agarwal, Anurag Chaudhary, Syed Salman Ali, Abdel-Nasser El-Shorbagi, Sachin Chaudhary, Prabhash Nath Tripathi
pp. 1149–1156 · DOI: 10.5530/ijper.58.4.126 · Published Oct-Dec 2024
Background Atherosclerosis is a complex progressive pathological process that produces lesions in the inner wall of an artery because of the abnormal lipid metabolism, and dysregulation of inflammatory processes. Increas…
Article
Biological Activity of Ethanol Extract of Terminalia chebula Dried Carp against Bacterial Wilt of Lycopersicum esculentum and its Mechanism of Inhibition
Padmalatha Ajith, SB Prabha
pp. 1157–1166 · DOI: IndJPhaEdRes-58-4-1157 · Published Oct-Dec 2024
Background The extract of Terminalia chebula was explored with a new perspective to control tomato bacterial wilt, opening up a new way in agriculture to control plant disease in an organic way with less impact on the en…
Article
Phytochemical Study, Polyphenols Determination and Evaluation of Antioxidant Activity of Satureja calamintha from Morocco
Asma Halmoune, Nadia Salhi, EL Finou Hamza, Ait Benlabchir Abdessamad, Khfif Khalid, Zaid Abdelhamid, El Rhaffari Ihoussaine
pp. 1167–1173 · DOI: 10.5530/ijper.58.4.128 · Published Oct-Dec 2024
Introduction The domestication of Satureja calamintha, either because of its superior tolerance to disease and environmental factors or because of its potential for larger quantities of useful chemicals. Materials and Me…
Article
The Therapeutic and Toxic Effects of Artemisia herba alba Extract on the Reproductive System and Fertility of Male Rabbits Oryctolagus cuniculus
Yasmina Moumen, Hichem Khammar, Cherif Abdennour, Yacine Zerouki, Meriem Zitouni
pp. 1174–1183 · DOI: 10.5530/ijper.58.4.129 · Published Oct-Dec 2024
Background Medicinal plants are generally considered beneficial to health because they contain secondary metabolites responsible for their therapeutic effects. However, some plants used in phytotherapy are toxic due to t…
Article
Enhancement of Solubility and Dissolution Rate of Poorly Soluble Anticancer Drug Using Nanostructured Lipid Carrier Based Drug Delivery System
Vidya Sabale, Manasi Jiwankar, Prafulla Sabale
pp. 1184–1188 · DOI: 10.5530/ijper.58.4.130 · Published Oct-Dec 2024
Background Prostate cancer is the leading cause of death in men over the age of 50, making it one of the most common cancers. Current treatments available such as chemotherapy, surgery are associated with many side-effec…
Article
The Effect of Sophoridine on NSCLC by Down Regulation of mTOR and NOTCH1
Mohammad Raghibul Hasan, Ali Hazazi, Ahad Amer Alsaiari, Fawaz M. Almufarriji, Amirah Albaqami, Osama Abdulaziz, Marwa K Darwish, Atul Kumar, Kapil Dev, Mohammed Ageeli Hakami
pp. 1373–1379 · DOI: 10.5530/ijper.58.4.147 · Published Jul-Sep 2024
Introduction Sophoridine, an alkaloid compound which is isolated from various plant species like Sophoraalopecuroides and Sophora flavescens. It identified to have potential pharmacological properties, including anti-inf…