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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Review

Bioactivities, Biopharmaceutics, and Advanced Drug Delivery Systems of Magnolol

Sabna Kotta1,2★, Bayan A. Eshmawi1, Amerh Aiad Alahmadi1, Hibah Mubarak Aldawsari1,2, Shaimaa M. Badr-Eldin1,2, Anroop B. Nair3★ Corresponding author

  1. 1Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, SAUDI ARABIA.
  2. 2Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, SAUDI ARABIA.
  3. 3Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.

CORRESPONDENCE

Sabna Kotta

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, SAUDI ARABIA.

sabnakotta@yahoo.co.in

Received: 28-08-2024; Revised: 21-10-2024; Accepted: 25-10-2024.

Volume 58, Issue 4S · pp. s1108–s1127 · PUBLISHED 2024 · DOI: 10.5530/ijper.58.4s.110

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ABSTRACT

Magnolia bark is an important food supplement. Magnolol (ML), 3,3′-Neoligna-8,8′-diene-4,4′- diol, is a bioactive phenolic molecule found in the Magnoliafamily. Advanced Drug Delivery Systems (DDSs) have been able to enhance therapeutic efficacy and reduce adverse effects of plant-derived bioactive. In the first part of the review, the bioactivities, mechanisms, and clinical prospects of ML are described. A brief explanation of the mechanisms of anti-inflammatory, antioxidant, cardiovascular-protective, neuroprotective, and anti-cancer effects of ML is also provided. Later, the detailed biopharmaceutics of ML is described under solubility, dissolution, bioavailability, and pharmacokinetics. The solubility of ML in different media pH is also explained. The bioavailability of pure ML and its pharmacokinetics after parenteral and oral administrations are described. Further, pharmacokinetics after single and multiple doses of ML is also discussed. Finally, the reported advanced DDSs of ML are reviewed critically. Engineered crystals, solid dispersions, microstructures, and nanostructures of ML-loaded DDSs are reviewed.

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    Kotta, S., Eshmawi, B. A., Alahmadi, A. A., Aldawsari, H. M., Badr-Eldin, S. M., & Nair, A. B. (2024). Bioactivities, Biopharmaceutics, and Advanced Drug Delivery Systems of Magnolol. Indian Journal of Pharmaceutical Education and Research, 58(4S), s1108–s1127. https://doi.org/10.5530/ijper.58.4s.110