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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Exploring the Ameliorative Potential of Barleria cristata in Cognitive Dysfunction Rat Model: Investigating Behavioral, Biochemical and Cellular Changes

Koppala Rakesh Viswa Sai Chaitanya1★, Sridevi Korimelli2★, Supriya Reddy Gaddam3★, Manuri Kavya4★, Ramya Chandupatla5★, Venna Rajeswari Surya Anusha6★★ Corresponding author

  1. 1Department of Pharmacology, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Tarnaka, Secunderabad, Telangana, INDIA.
  2. 2Department of Pharmacology, School of Pharmaceutical Sciences and Technologies, JNTUK, Kakinada, Andhra Pradesh, INDIA.
  3. 3Department of Pharmacology, CMR College of Pharmacy, Kandlakoya, Medchal, Telangana, INDIA.
  4. 4Department of Pharmacology, Vignan Institute of Pharmaceutical Technology, Kapujaggarajupeta, Visakhapatnam, INDIA.
  5. 5Department of Pharmacology St Mary’s College of Pharmacy, St.Francis street, Hyderabad, Telangana, INDIA.
  6. 6Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Nizampet, Hyderabad, Telangana, INDIA.

CORRESPONDENCE

Koppala Rakesh Viswa Sai Chaitanya

Department of Pharmacology, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Tarnaka, Secunderabad. Telangana, INDIA.

koppala526@gmail.com

Received: 27-07-2024; Revised: 17-01-2025; Accepted: 09-05-2025.

Volume 59, Issue 3S · pp. s950–s960 · PUBLISHED Jul-Sep 2025 · DOI: 10.5530/ijper.20250416

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ABSTRACT

Background: Cognitive impairment is a pervasive and perplexing concern that transcends the boundaries of various neuropsychiatric disorders like schizophrenia and Alzheimer’s. As research continues to unravel the intricacies of Barleria cristata's bioactive compounds, it offers promising prospects for the new therapeutic agents in the realm of natural medicine. Materials and Methods: In present study the ameliorative effect of methanolic leaf extract of Barleria cristata in ketamine induced cognitive dysfunction in rats. Locomotor activity (forced swim test), step down latency and transfer latency were determined for behavioral assessment followed by biochemical estimation of malondialdehyde, reduced glutathione and catalase activity Results: Barleria cristata methanolic extract treatment significantly mitigated cognitive impairment in ketamine induced rats with improvement in short and long term memory. Furthermore, it significantly reduced the lipid peroxidation and improved the levels of reduced glutathione and catalase in rats. On histopathological examination Barleria cristatamethanolic extract revealed dose-dependent substantial neuroprotection, by maintaining normal neurons with less neurodegenerative changes. Conclusion: Barleria cristata methanolic extract effectively mitigates cognitive impairment, oxidative stress and neurodegeneration in ketamine-induced rats, demonstrating significant neuroprotective properties.

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    Chaitanya, K. R. V. S., Korimelli, S., Gaddam, S. R., Kavya, M., Chandupatla, R., & Anusha, V. R. S. (2025). Exploring the Ameliorative Potential of Barleria cristata in Cognitive Dysfunction Rat Model: Investigating Behavioral, Biochemical and Cellular Changes. Indian Journal of Pharmaceutical Education and Research, 59(3S), s950–s960. https://doi.org/10.5530/ijper.20250416