Volume 59, Issue 3S

2025 · pp. s1191–s1191 · 42 articles

Volume: 59
Issue: 3S
Published: 2025
Pages: s1191–s1191
Articles: 42
Sections: 3
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article Corrigendum

In this issue

Review Article

Review
Mesoporous Silica Nanoparticles: A Promising Portal for Diagnosis and Treatment for Chronic Diseases
Saravanakumar Kasimedu, UshaPriya Halapaka Selvam, Keerthishree Suresh Sharma, Navina Sreenivasan Arrivur, Niranjan Babu Mudduluru
pp. s776–s787 · DOI: 10.5530/ijper.20251674 · Published Jul-Sep 2025
Nanotechnology is a promising technology in the creation of novel strategies in the field of the healthcare domain. Nano distribution of pharmaceuticals emerging new features for enhanced targeted drug delivery in the di…
Review
Nanostructured Lipid Carrier to Improve Oral Bioavailability
Pooja Harakal, Nilesh Kulkarni, Suvarna Gore, Komal Khade, Shashikant Dhole
pp. s788–s801 · DOI: 10.5530/ijper.20255950 · Published Jul-Sep 2025
Oral administration is the best way to administer both traditional and novel drugs because it decreases patient non-compliance and can also relieve the pain and discomfort associated with parenteral preparations. However…
Review
A Comprehensive Review on Management of Insulin Resistance Disorder by Innovative Technologies and Advancement of Precision Medicinal Therapies
Aman Shrivastava, Sumeet Dwivedi, Shiv Narayan, Abhishek Dwivedi, Jailani Shiekmydeen, Amit Anand, Arvind Kumar Tripathi, Kuldeep Singh
pp. s814–s824 · DOI: 10.5530/ijper.20250849 · Published Oct-Dec 2025
The increasing prevalence of insulin resistance disorders, including type 2 diabetes and metabolic syndrome, underscores the urgent need for advanced diagnostic and therapeutic strategies. This review aims to explore the…

Original Article

Article
A Review on Preparation Methods of Drug Loading Solid Lipid Nanoparticles with the Application in various Cancer Treatment
Mayur Popat Sawant, Gitanjali Sambhajirao Deokar
pp. s802–s813 · DOI: 10.5530/ijper.20257267 · Published Jul-Sep 2025
The pharmaceutical and cosmetics industries, as well as the domains of research and clinical medicine, have all benefited from the advent of Solid Lipid Nanoparticles (SLN) as a promising new drug delivery technique. The…
Article
Formulation and Evaluation of Orally Disintegrating Tablet Containing Aripiprazole in the Context of Quality by Design Approach
Mehmet Kalayı, Arkan Yashar Barbar, Buket Aksu
pp. s825–s836 · DOI: 10.5530/ijper.20256989 · Published 2025
Aim/Background The objective of this research is to develop and enhance the formulation of aripiprazole rapid disintegrating tablets utilizing the Quality by Design (QbD) methodology. Materials and Methods A full factori…
Article
Synthesis and Characterization of Novel HPMC Phthalate Succinate Polymers for Pharmaceutical Applications
Nagella Raveendra Babu, Rajendra Awasthi, Dhawal Ankola, Dheeraj Nagpal
pp. s837–s850 · DOI: 10.5530/ijper.20251074 · Published Jul-Sep 2025
Aim: The current article aimed to synthesize new HPMC derivative polymers by esterification method. Background: 2 most common causes of drug candidate failures are a lack of effectiveness and PK/bioavailability issues. V…
Article
Nepafenac Loaded Emulgel for Controlled Ocular Delivery: In vitro and Ex vivo Characterization
Babita Agarwal, Sachin Jagdale, Tejaswini Kanakdande, Rushikesh Shinde
pp. s849–s862 · DOI: 10.5530/ijper.20251113 · Published Jul-Sep 2025
Objectives: Emulgel, known for their unique combination of properties from both emulsions and gels, have attracted significant interest from the pharmaceutical and cosmetic industries for their versatility and usefulness…
Article
Dolutegravir Solid Dispersions as Oro-Dispersible Tablets: To Ameliorate the Integrase Inhibition Effect
Lakshmi Devi Gottemukkula, Raghuveer Pathuri, Sunitha Sampathi
pp. s863–s873 · DOI: 10.5530/ijper.20255690 · Published Jul-Sep 2025
Background: Dolutegravir (DTG) is an integrase strand transfer inhibitor that prevents the integration of viral DNA into host cell DNA, which is one of the key phases in the life cycle of HIV, preventing the virus from m…
Article
Preformulation Studies and Pseudo-Ternary Phase Diagram Development for Dolutegravir Sodium: A Foundational Step toward SMEDDS Design
Jayadev Hiremath, Nimbagal Raghavendra Naveen, Prakash Goudanavar, Girish Meravanige, Santosh Fattepur, Rashed M. Almuqbil, Bandar Aldhubiab, Sreeharsha Nagaraja
pp. s874–s880 · DOI: 10.5530/ijper.20252845 · Published Jul-Sep 2025
Background: Dolutegravir Sodium (DTG) is a poorly soluble antiretroviral drug that will find it difficult to achieve oral bioavailability. Preformulation and screening of excipients are mandatory as a stepping stone in f…
Article
Development and Assessment of a Novel Absorption Base and Permeability-Enhanced Diclofenac Diethylamine Transdermal Cream
Rutuja Aher, Ritesh Karmarkar, Yash Bachhav, Kunal Bhambar, Poonam Patil
pp. s881–s889 · DOI: 10.5530/ijper.20251391 · Published Jul-Sep 2025
Background: Background of the present research study was to investigate shea butter as absorption base and nerolidol as permeability enhancer for transdermal delivery of diclofenac diethylamine. Hypothesis: In present st…
Article
Quality by Design Based Formulation and Development of a Novel Bi-Compound Pharmaceutical Capsule: An Innovative Approach for the Treatment of Hypertension
Aiman Rabiya, Mohamed Hassan Dehghan
pp. s890–s901 · DOI: 10.5530/ijper.20252275 · Published Jul-Sep 2025
Objectives: This study aimed to develop a novel bi-compound pharmaceutical capsule containing nifedipine gastro-retentive floating microspheres and telmisartan immediate-release solid dispersions using a Quality by Desig…
Article
Design Development and Ex vivo Evaluation of Dorzolamide Nanoparticles Laden Contact Lens for Management of Glaucoma
Sagar Koirala, Preethi Sudheer, Litha Thomas, Ashwini Alur, Johnsi Srinivasan
pp. s902–s909 · DOI: 10.5530/ijper.20256572 · Published Jul-Sep 2025
Background: The current study aimed to design dorzolamide hydrochloride nanoparticle (NP)-laden contact lenses to control drug release for the effective management of glaucoma. Materials and Methods: Ionotropic gelation …
Article
Apoptotic Effects of Hypericum dogonbadanicum on Lung and Gastric Cancer Cell Lines
Seyyedeh Mahdokht Maddah, Golaleh Mostafavi, Masoud Vaali, Ehsan Ranjbar
pp. s910–s920 · DOI: 10.5530/ijper.20255499 · Published Jul-Sep 2025
Aim/Background: Cancer is the second deadliest disease worldwide. Medicinal plants have been recognized for their cytotoxic and antitumor properties. This study aimed to assess the potential anticancer effects of the hyd…
Article
Effect of Ethanol Extract of Rosella Flower (Hibiscus sab- dariffa L.) on the Expression of Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1) in the Healing Process of Incision Wounds in White Wistar Rats
Ade Dwi Pratiwi, Jekson Martiar Siahaan, Endy Juli Anto
pp. s921–s929 · DOI: 10.5530/ijper.20250752 · Published Jul-Sep 2025
Background: This study investigated the effect of rosella flower petal (Hibiscus sabdariffa L.) ethanol extract gel on incision wound healing in a rat model of diabetes mellitus. Wounds are skin disorders that can be cau…
Article
Exploring Phytocompounds’ Interaction with Multi-Serotype Dengue Virus NS5-MTase: Insights into Binding Affinity and Activity
Afaf Salim Alwabli, Mohammed Balubaid, Mohammed Tarique
pp. s930–s944 · DOI: 10.5530/ijper.20251313 · Published 2025
Background Dengue Virus (DENV) infection poses a formidable global health threat, spanning from mild breakbone fever to severe conditions such as dengue hemorrhagic fever and dengue shock syndrome. The NS5-MTase enzyme a…
Article
Novel Solar Micro Dryer for Aromatic and Medicinal Plants
Ahmed Ridha El Ouederni, Rania Omrani, Sonia Taktouk, Yasmine El Ouederni, Nour El Ouederni, Aida Katar
pp. s945–s949 · DOI: 10.5530/ijper.2025489 · Published Jul-Sep 2025
Background: This paper focuses on an experimental investigation of an indirect solar dryer, specifically designed for drying aromatic and medicinal plants. Objectives: The purpose of this study is to utilize solar energy…
Article
Exploring the Ameliorative Potential of Barleria cristata in Cognitive Dysfunction Rat Model: Investigating Behavioral, Biochemical and Cellular Changes
Koppala Rakesh Viswa Sai Chaitanya, Sridevi Korimelli, Supriya Reddy Gaddam, Manuri Kavya, Ramya Chandupatla, Venna Rajeswari Surya Anusha
pp. s950–s960 · DOI: 10.5530/ijper.20250416 · Published Jul-Sep 2025
Background: Cognitive impairment is a pervasive and perplexing concern that transcends the boundaries of various neuropsychiatric disorders like schizophrenia and Alzheimer’s. As research continues to unravel the intrica…
Article
Cytotoxicity Assay, Antioxidant Activity and Investigation of Bioactive Compounds Using GC-MS in the Leaves Extracts of Cinnamomum tamala (Buch. -Ham.)
Sushmita Semwal, Neeraj Kumar, Bhuwan Chandra Joshi, Pankaj Budhlakoti
pp. s961–s968 · DOI: 10.5530/ijper.20251207 · Published Jul-Sep 2025
Background: Cinnamomum tamala(Lauraceae), commonly known as Tejpaat or Bay leaves, find application in foods, along with traditional uses for curing a number of ailments. The objective of the current study was to investi…
Article
Exploring the Nephroprotective Efficacy of Leucaena leucocephala Seeds in Mitigating Cisplatin-Induced Renal Damage
Umar Farooq Mir, Deepak Kumar Jha, Sandipan Chatterjee, Harshitha Nagaraj, Mehdi Fathima, Saroj Kumar Sah
pp. s969–s977 · DOI: 10.5530/ijper.20251234 · Published Jul-Sep 2025
Objectives: The study aimed to evaluate the nephroprotective effects of the methanolic extract of Leucaena leucocephala seeds against Cisplatin-Induced Nephrotoxicity (CIN) in rats through biochemical, antioxidant and hi…
Article
Cassia auriculata Stem Bark Ameliorates the HFD+STZ-Induced Diabetes in both in vitro and in vivo Model
Saravanan Muthaiah, Seema Mudhol, Muthukumar Serva Peddha
pp. s978–s988 · DOI: 10.5530/ijper.20256700 · Published Jul-Sep 2025
Background: The secondary metabolites from natural herbs are exploited to treat various human ailments. The present study aimed to investigate the ameliorative effect of the methanolic extract of Cassia auriculata (C. au…
Article
Exploring the Green Potential of Quercetin-Enhanced Strontium Oxide Nanoparticle Scaffold on Mesenchymal Stem Cells BMP-2 Expression
Rieshy Vasudevan, Priyangha Ponmudi Thangavel
pp. s989–s994 · DOI: 10.5530/ijper.20257040 · Published Jul-Sep 2025
Aim: The study aimed to create a scaffold infused with Quercetin-enhanced strontium oxide nanoparticles and assess its impact on BMP-2 expression in MSCs. Materials and Methods: Scaffold fabrication involved mixing 1% Hy…
Article
Ethnomedicinal Plants of North-Eastern India: Unveiling Phenolic Composition and Antioxidant Activity for Skin Health
Phatik Tamuli, Rajib Gogoi, Kausik Chaudhuri, Basundhara Pillai, Tapan Seal
pp. s995–s1011 · DOI: 10.5530/ijper.20254855 · Published Jul-Sep 2025
Background: Skin diseases are a major health concern due to their link with oxidative stress, inflammation, tissue damage and impaired skin function. Antioxidants play a crucial role in addressing these issues and offer …
Article
Antigenotoxic Activity of Carissa spinarum (L.) Leaves Extract against Allethrin-Induced Genotoxicity in Allium cepa (L.) Meristematic Cells
Sivaranjani Varadharajan, Parthiban Pandian
pp. s1012–s1019 · DOI: 10.5530/ijper.20255649 · Published Jul-Sep 2025
Aim: The purpose of this research was to evaluate the phytochemical composition and antigenotoxic properties of Carissa spinarum leaf extract against allethrin-induced genotoxicity in Allium cepa (L.) meristematic cells.…
Article
A Decade of Medical Pharmacology Speciality and Ph.D. Theses in Turkey: A Comparative Study
Mert Can Ongun, Hulagu Bariskaner
pp. s1020–s1025 · DOI: 10.5530/ijper.20255889 · Published 2025
Objectives This study aimed to analyse the characteristics and publication trends of medical pharmacology specialty and Ph.D. theses. Materials and Methods Medical pharmacology theses published in Turkey between 2010 and…
Article
Ivabradine Enhances its Positive Impact on the Heart Muscle/ (Myocardial Infarction) by Modulating Myocardial Nitric Oxide and ATP-dependent K+ Channels but not by Adenosine and Bradykinin Levels
Junaid Tantray, Ashish Kumar Sharma, Rajesh Kumar Sharma
pp. s1026–s1040 · DOI: 10.5530/ijper.20251359 · Published Jul-Sep 2025
Background: This study aimed to explore the cardioprotective effects of ivabradine and examine potential secondary mechanisms beyond the established role of If-HCN channel inhibition demonstrated in cellular studies. Obj…
Article
Synergistic Suppression of DMBA-Induced Breast Cancer in Rats: Exploring the Preventive Potential of Diclofenac Sodium and D-Limonene Combination through mTOR Inhibition
Srivarshini Sankar, Gothandam Kodiveri Muthukaliannan
pp. s1040–s1047 · DOI: 10.5530/ijper.20255758 · Published Jul-Sep 2025
Background: To examine the combination of Diclofenac sodium (DCF) and D-Limonene's (LIM) preventative effects against DMBA-induced breast cancer in a rat model. Materials and Methods: 7,12-Dimethylbenz[a]Anthracene (DMBA…
Article
Evaluation of Respirable Fraction by Next Generation Impactor for Beclomethasone and Formoterol Fumarate Dihydrate Metered Dose Inhaler
Chirag Chilka, Khushal Kapadiya, Darshan Jani, Jayesh Dhalani
pp. s1048–s1056 · DOI: 10.5530/ijper.20256558 · Published Jul-Sep 2025
Introduction: Asthma and Chronic Obstructive Pulmonary Disease are treated with a combination pharmaceutical aerosol (Pressurized Metered Dose Inhaler) dose form, such as Formoterol fumarate dihydrate and Beclomethasone …
Article
Maslinic Acid Therapeutic Effect in Rheumatoid Arthritis Through Activation of Nuclear Factor Erythroid 2 and Suppression of Nuclear Factor Kappa B as well as Apoptotic Markers
Ahmed Mohamed Darwish, Saeed Mohammed Alqahtani, Salah Omar Bashir, Hind Awad Zafrah, Amal Fahmy Dawood, Deema Kamal Sabir, Mahmoud Mohamed Morsy, Hamzeh Ahmed Al-Daher, Mohamed Darwesh Morsy, Muataz Elsiddig Mohamed, Dalia Fathi El Agamy
pp. s1057–s1065 · DOI: 10.5530/ijper.20250845 · Published Oct-Dec 2025
Background: Rheumatoid Arthritis (RA) is a chronic autoimmune condition characterized by persistent joint inflammation, resulting in pain, stiffness and degradation. Despite advances in understanding RA pathophysiology, …
Article
Effect of Wedelia chinensis Leaf Extracts against Ethylene Glycol Induced Urolithiasis in Rats
Sunil Sidramayya Mathapati, Mallinath Kalshetti
pp. s1066–s1073 · DOI: 10.5530/ijper.20256632 · Published 2025
Background Finding a hyperoxaluria treatment that especially targets lowering oxalate excretion is essential due to the drawbacks of present urolithiasis treatments. It's interesting to note that Wedelia chinensis (Famil…
Article
Anti-Inflammatory Activity of Gallic Acid by Suppression of Cyclooxygenase, Lipoxygenase and Nitric Oxide
Veerabhuvaneshwari Veerichetty, Saraswathy Nachimuthu
pp. s1074–s1082 · DOI: 10.5530/ijper.20254515 · Published Jul-Sep 2025
Background: Gallic acid, trihydroxy benzoic acid is a phenolic compound abundant in various fruits and plants with potent antioxidant and anti-inflammatory properties. This study aims to investigate dual COX LOX inhibiti…
Article
A Convenient Synthesis of Glutarates Derivatives: Application, Theoretical DFT Calculations and Molecular Docking Study
Maha Ameur, Rania Omrani, Sonia Taktouk, Mohamed Amine Ben Abdallah, Ahmed Ridha El Ouederni, Rafik Gatri
pp. s1083–s1089 · DOI: 10.5530/ijper.20255204 · Published Jul-Sep 2025
Background: An easy and convenient access to a novel Gluatarate Derivatives (DCG) was successfully synthesized, using an unusual successive SN2-SN2 reaction of 1,4-Diazabicyclo [2.2.2] Octane (DABCO) then KCN, on the ava…
Article
Synthesis, Characterisation and Evaluation of Benzimidazoles Containing Biphenylcarbonylpiperazine at C-2 Position for Antipsychotic Activity
Rani S. Kankate, Zenish J. Jain, Shantanu S. Ghodke, Paraag S. Gide, Kaustubh S. Patil, Smita P. Kakad, Sunita N. Surse
pp. s1090–s1100 · DOI: 10.5530/ijper.20256783 · Published Jul-Sep 2025
Aim/Background: The development of antipsychotic medications with a better clinical profile and fewer neurological side effects is still necessary. Since it is widely known that a dopamine D2 opposing component is requir…
Article
A Statistical Based Estimation of Candesartan and Simvastatin Using Simultaneous Estimation, First Order Derivative and Q Value Method by UV Spectrophotometry
Sarwar Jaman, Arindam Maity, Saptarshy Sarkar, Anjan Mondal, Bishal Banerjee, Padmacharan Behera, Suddhasattya Dey, Arijit Mondal
pp. s1101–s1119 · DOI: 10.5530/ijper.20251345 · Published Jul-Sep 2025
Aim/Background: When combined with simvastatin, candesartan is a more potent antihypertensive medication than statins by itself. Therefore, to estimate Candesartan and Simvastatin concurrently in the mixture, a quick, ec…
Article
Development of an Ion Chromatography Method for the Determination of Organic Impurities in Ferumoxytol
Naga Sankara Rao Deepala, Sasikanth Pedapalli, Kantamsetti Jagadeesh, Mohammad Shahidul Islam, Prakash Gadipelli, Kholood A. Dahlous, Mahboob Alam, Rudraraju Ramesh Raju
pp. s1110–s1116 · DOI: 10.5530/ijper.20251319 · Published Jul-Sep 2025
Aim: To the development of an ion chromatography method for the determination of organic impurities in Ferumoxytol. Materials and Methods: A new ion chromatographic method was employed for the precise and suitable quanti…
Article
ICH M10-Based Validation of a Novel Chromogenic Bioanalytical Method for Quantifying Hesperidin in Biological Samples
Khagga Bhavya Sri, Jinkala Pravallika, Mogili Sumakanth
pp. s1117–s1125 · DOI: 10.5530/ijper.20251481 · Published Jul-Sep 2025
Aim: A Chromogenic bioanalytical approach had been developed as well validated for the assessment of specific compound hesperidin in accordance with the ICH M10 guidelines. 2,6-Dichloro quinone 4-chloro imide chromogenic…
Article
An Improved Method Development and Validation for the Quantification of Clomifene in Pharmaceutical Formulation and Biological Matrix by LC-MS/MS
Rubina Kauser, Padavala Sunil Kumar Chaitanya, Palanivel Venkatesan
pp. s1126–s1133 · DOI: 10.5530/ijper.20255465 · Published Jul-Sep 2025
Aim: The major objective of current work was to create sensitive tandem mass spectrometric method using electrospray ionization and liquid chromatography for quantifying Clomifene in biological matrices Materials and Met…
Article
Quantification of Miconazole Nitrate and Eugenol in Formulated Emulgel by Planar Chromatography along its Stability Studies
Aarti Sachin Zanwar, Dhanya B Sen, Pruthvi Hiteshkumar Vyas, Sushil Sureshrao Burle, Dipti Bipinchandra Ruikar, Ashim Kumar Sen
pp. s1134–s1140 · DOI: 10.5530/ijper.20255177 · Published Jul-Sep 2025
Introduction: Fungal infections are rapidly increasing and combination therapy using Miconazole Nitrate (MCZ) and Eugenol (EGN), may offer a promising approach for developing new antifungal medications. Objectives: The p…
Article
From Prescription to Plate: Evaluating Drug-Drug and Drug-Food Interactions in the Prescriptions Dispensed in Community Pharmacies of Northern Cyprus
Ozgur Karatasli, Syed Sikandar Shah, Aftab Alam, Syed Arman Rabbani, Mevhibe Tamirci
pp. s1141–s1152 · DOI: 10.5530/ijper.20251254 · Published Jul-Sep 2025
Background: The effect of drug on a person may be different than anticipated when the drug interacts with another drug/drugs the person is taking, or the food, beverages and dietary supplements the person is consuming. M…
Article
Assessing Knowledge, Attitude, Potential Barriers and Analysis of Motivational Factors of Blood Donation among Young Adults in an Endemic Area of Hemoglobinopathies in Saudi Arabia
Gasim Dobie, Bashayer Ahmed Alfaifi, Nameer Ali Fageehy, Fatimah Mabrook Alhaqawe, Khaled Essawi, Waleed Hakami, Rama Mohan Chandika, Muhammad Saboor, Aymen Madkhali, Abdullah Ahmed Mobarki, Maymoon Mohammed Madkhali, Hassan Abdu Hamali
pp. s1153–s1162 · DOI: 10.5530/ijper.20255821 · Published Jul-Sep 2025
Background: Blood and blood products are indispensable, lifesaving and essential in all components of healthcare systems globally. Blood (and blood product) transfusion is crucial for both routine and emergency medical p…
Article
Potentially Inappropriate Psychotropic Drug Prescriptions and Polypharmacy among Geriatric Home Healthcare Patients: A Cross-Sectional Study
Selin Tanyeri Kayahan, Ali Kayahan
pp. s1163–s1174 · DOI: 10.5530/ijper.20256020 · Published 2025
Introduction Comorbidities, psychotropic drug use and polypharmacy are common in elderly individuals. Research evaluating the psychotropic drug prescriptions among geriatric patients in a homecare health setting is limit…
Article
Analysis of Indian Pharmaceutical Industry and Trade Competitiveness: Using Revealed Comparative Advantage (RCA)
Devinder Singh Hooda, Anu A
pp. s1175–s1191 · DOI: 10.5530/ijper.20250648 · Published Jul-Sep 2025
Introduction: This paper examines the growth of the Indian pharmaceutical sector, the changing dynamics and the export competitiveness of therapeutic segments. Further, this study compared the export competitiveness of t…

Corrigendum

Article
Corrigendum: Development of Thermosensitive Ophthalmic in situ Gels of Bimatoprost for Glaucoma Therapy
Corrigendum
pp. s1191–s1191 · DOI: · Published 2025
Based on the authors' description the following figures are to be considered: Figure 7 has been updated and replaced with the corrected version provided below.