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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Cassia auriculata Stem Bark Ameliorates the HFD+STZ-Induced Diabetes in both in vitro and in vivo Model

Saravanan Muthaiah3★, Seema Mudhol2★, Muthukumar Serva Peddha1★★ Corresponding author

  1. 1Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka, INDIA.
  2. 2Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, INDIA.
  3. 3Department of Toxicology, Vipragen Biosciences Private Limited, Hootagalli, Mysore, Karnataka, INDIA.

CORRESPONDENCE

Saravanan Muthaiah

Dr. Muthukumar Serva PeddhaChief Scientist and Professor, Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore-570020, Karnataka, INDIA.

muthukumar@cftri.res.in

Received: 05-05-2024; Revised: 08-08-2024; Accepted: 22-02-2025.

Volume 59, Issue 3S · pp. s978–s988 · PUBLISHED Jul-Sep 2025 · DOI: 10.5530/ijper.20256700

View on IJPER original site ↗

ABSTRACT

Background: The secondary metabolites from natural herbs are exploited to treat various human ailments. The present study aimed to investigate the ameliorative effect of the methanolic extract of Cassia auriculata (C. auriculata) stem-bark in both in vitro and in vivo mice model. Materials and Methods: In vitrostandard procedures were followed to determine the phytochemical profile. High-fat-diet+STZ was administered to 6-weeks old mice to induce type-2-diabetes. Results: In vitrostudy revealed that the highest total polyphenol and flavonoid contents with anti-oxidant and anti-diabetic property was observed in the methanolic extract ofC. auriculatastem-bark. Type-2-diabetes rats showed significantly elevated fasting blood glucose levels with decreased serum insulin level. Further, the oxidative stress in the serum and muscle as well as altered activities of liver enzymes of carbohydrate metabolism in diabetic control mice compared to normal control mice was observed. The histomorphology of liver and pancreas was deleteriously altered in diabetic group mice. However, methanolic extract of C. auriculatastem-bark (200 mg/kg; b.wt) and metformin (200 mg/kg; b.wt) treated diabetic mice did not show the above-mentioned alterations suggesting its ameliorative effect in type-2-diabetes. Conclusion: The methanolic extract of C. auriculata is potent enough to be employed as antidiabetic agent.

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    Muthaiah, S., Mudhol, S., & Peddha, M. S. (2025). Cassia auriculata Stem Bark Ameliorates the HFD+STZ-Induced Diabetes in both in vitro and in vivo Model. Indian Journal of Pharmaceutical Education and Research, 59(3S), s978–s988. https://doi.org/10.5530/ijper.20256700