Optimized Green Synthesis Approaches of Phenytoin Using Divalent Sulfate Salts and Chromatographic Purity Assessment via A Novel RP-HPLC Method
1, 1, 1, 2, 3, 1,3★★ Corresponding author
- 1Department of Pharmaceutical Chemistry, Bharat Technology, Jadurberia, Uluberia, Howrah, West Bengal, INDIA.
- 2Department of Pharmacology, Bharat Technology, Jadurberia, Uluberia, Howrah, West Bengal, INDIA.
- 3School of Pharmaceutical Science, SOA University, Khandagiri, Bhubaneswar, Odisha, INDIA.
CORRESPONDENCE
Shambo Panda
Department of Pharmaceutical Chemistry, Bharat Technology, Jadurberia, Uluberia, Howrah, West Bengal, INDIA.
Received: 22-12-2025; Revised: 09-02-2026; Accepted: 14-04-2026.
Volume 60, Issue 3S · pp. s1–s8 · 2026 · DOI: 10.5530/ijper.20262650
ABSTRACT
Background: Phenytoin is a first-line anti-epileptic drug. Conventionally, It is synthesized by using Benzil and urea in the presence of concentrated HCl. Our aim is to increase the yield as well as the purity of Phenytoin by applying Green approaches and developing an RP-HPLC method for purity assessment.Materials and Methods: 3 different reaction is carried out by using Copper sulfate, Ferrous sulphate and Aluminium sulfate as catalysts along with Benzoin, Sodium nitrate and acetic acid as solvents. Another reaction carried out changing acetic acid with ethanol and the catalyst was Ferrous sulphate. Results and Conclusion: Phenytoin prepared by ferrous sulphate with ethanol gives the highest yield as well as the highest purity compared to other catalysts.
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Chakraborty, A., Nath, R., Debnath, B., Das, A., Bose, A., & Panda, S. (2026). Optimized Green Synthesis Approaches of Phenytoin Using Divalent Sulfate Salts and Chromatographic Purity Assessment via A Novel RP-HPLC Method. Indian Journal of Pharmaceutical Education and Research, 60(3S), s1–s8. https://doi.org/10.5530/ijper.20262650