Optimization of Novel Topical Cubosomal Gel Containing Lidocaine Hydrochloride by Design of Experiment

ABSTRACT

Background: Cubosomal gels have emerged as a favourable mode for delivery of drugs, contributing to release of drug in controlled mode with increased effectiveness. The study aimed to develop an optimized cubosomal gel formulation containing Lidocaine Hydrochloride for sustained pain relief, particularly in post-operative pains. Materials and Methods: Bottom-up method of approach was employed to prepare cubosomes utilizing Glyceryl Mono Oleate (GMO) and Poloxamer 407 (P-407). The formulations underwent comprehensive characterization analysis, entrapment efficiency determination and zeta potential measurement. Utilizing Design of Experiment methodology, an optimized formulation LH8, prepared with medium concentration of GMO and high concentration of P-407 was derived. Subsequently, LH8 was incorporated into a gel base and evaluated for various parameters including viscosity, drug content, extrudability, and spreadability. In vitro and ex vivo permeation studies were conducted to assess the sustained release profile. Results: The optimized formula LHG8 prepared with medium concentration of Carbopol and high concentration of Propylene glycol showed flux of 38.29 μg/cm2, 66.8% permeability, 7.1 cm spreadability and 91.2% extrudability. Importantly, LHG8 demonstrated excellent sustained release activity, indicating its potential for effective post-operative pain management. Conclusion: This study highlights the promise of cubosomal gels as a viable strategy for optimizing drug delivery, with implications for improving patient outcomes in pain management

KEYWORDS

• Cubosomal Gel
• Drug Delivery
• Factorial Design
• Lidocaine Hydrochloride
• Optimization
• Sustained Release

Showing references and in-text citations exactly as published.

• DOI10.5530/ijper.20262598Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPER.

• Article · VOLUME 60, ISSUE 4SFormulation and Evaluation of Liquisolid Tablet with Enhanced Dissolution of Ivacaftor by Using Box-Behnken DesignManisha Dnyanoba Chate, Swaroop Rameshwarji Lahoti · pp. s1405–s1415Original ArticleSame type: Article
• Article · VOLUME 60, ISSUE 4SDevelopment and Evaluation of Polymer-conjugated Solid Fast Dissolving Tablets of Ambroxol HydrochlorideVidhan Chand Bala, Mukesh Kumar Singh, Amit Kumar, Arvind Kumar Patel, Sunil Kumar Tiwari, Asheesh Kumar Gupta, Sushil Kumar · pp. s1416–s1429Original ArticleSame type: Article
• Article · VOLUME 60, ISSUE 4SQuality by Design Development of a Thermosensitive in situ Gel for Enhanced Ocular Delivery of CarvedilolAnurag Rajendra Panade, Sandip Akaram Bandgar, Riya Raghunath Patil, Indrayani Sandip Bandgar · pp. s1430–s1444Original ArticleSame type: Article
• Article · VOLUME 60, ISSUE 4SNovel Application of Mixed Solvency Concept for the Development of Topical Emulgel Formulations of Poorly Water-Soluble Drug, Piroxicam, and their EvaluationsJitendra Singh, Prateek Sahu, Sharad Prakash Pandey, Rajesh Kumar Maheshwari · pp. s1445–s1460Original ArticleSame type: Article