Volume 60, Issue 4S

2026 · pp. s1364–s1373 · 41 articles

Volume: 60
Issue: 4S
Published: 2026
Pages: s1364–s1373
Articles: 41
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Advancing Breast Cancer: Strategies to Counteract Taxane Resistance in Her2-Positive and Triple-Negative Breast Cancer
Deepak Thakre, Priyanka Singanwad, Milind Umekar, Amol Tatode, Nishant Awandekar, Mohammad Qutub, Ujban Mohammad Hussain
pp. s1364–s1373 · DOI: 10.5530/ijper.20261755 · Published 2026
Resistance is one of the major problems in chemotherapy during Breast Cancer (BC) treatment. Earlier treatments, such as radiation, surgery, and chemotherapy including taxane-based therapies like paclitaxel and docetaxel…
Review
Natural Products and Cellular Senescence Research: A Scientometric Analysis of Global Trends, Thematic Clusters, and Emerging Frontiers (2016-25)
Rashed M Almuqbil, Bandar Aldhubiab, Mueen Ahmed K. K, Chaman Sab M
pp. s1374–s1382 · DOI: 10.5530/ijper.20265864 · Published 2026
Background: Interest in natural products-polyphenols, flavonoids, terpenoids, and related phytochemicals-as candidate senotherapeutic and geroprotective agents has expanded rapidly over the past decade, yet the literatur…
Review
Recent Trends in Chemistry and Pharmacology-Based Research Using Pyrrolidine Scaffolds: An Up-to-Date
Km. Anjali, Arun Kumar Mishra
pp. s1383–s1395 · DOI: 10.5530/ijper.20263772 · Published 2026
Pyrrolidine is a saturated five-membered nitrogen-containing heterocycle widely recognized as a privileged scaffold in medicinal chemistry. Its conformational flexibility, strong basicity, and hydrogen-bonding capability…

Original Article

Article
Formulation and Evaluation of Liquisolid Tablet with Enhanced Dissolution of Ivacaftor by Using Box-Behnken Design
Manisha Dnyanoba Chate, Swaroop Rameshwarji Lahoti
pp. s1405–s1415 · DOI: 10.5530/ijper.20262408 · Published 2026
Introduction: Ivacaftor a drug falling under BCS class II due to its low solubility, with a bioavailability of around 20%. In this study, the novel liquisolid technique is used to enhance the dissolution and ultimately i…
Article
Development and Evaluation of Polymer-conjugated Solid Fast Dissolving Tablets of Ambroxol Hydrochloride
Vidhan Chand Bala, Mukesh Kumar Singh, Amit Kumar, Arvind Kumar Patel, Sunil Kumar Tiwari, Asheesh Kumar Gupta, Sushil Kumar
pp. s1416–s1429 · DOI: 10.5530/ijper.20262915 · Published 2026
Objectives: This study aimed to develop polymer-conjugated Fast Dissolving Tablets (FDTs) of ambroxol hydrochloride using direct compression with Amberlite IPR64 and Sodium Starch Glycolate (SSG) to achieve effective tas…
Article
Quality by Design Development of a Thermosensitive in situ Gel for Enhanced Ocular Delivery of Carvedilol
Anurag Rajendra Panade, Sandip Akaram Bandgar, Riya Raghunath Patil, Indrayani Sandip Bandgar
pp. s1430–s1444 · DOI: 10.5530/ijper.20263018 · Published 2026
Introduction: This research focuses on formulating a thermoresponsive in situ gel containing Carvedilol for ocular delivery, employing a Quality by Design (QbD) strategy to improve therapeutic effectiveness in glaucoma m…
Article
Novel Application of Mixed Solvency Concept for the Development of Topical Emulgel Formulations of Poorly Water-Soluble Drug, Piroxicam, and their Evaluations
Jitendra Singh, Prateek Sahu, Sharad Prakash Pandey, Rajesh Kumar Maheshwari
pp. s1445–s1460 · DOI: 10.5530/ijper.20266485 · Published 2026
Aim: The objective of this research was to investigate the mixed solvency concept as a means to enhance the solubility of Piroxicam and to develop an optimized microemulsion-based gel formulation suitable for topical app…
Article
Formulation Considerations and in vitro Characterization of Polymeric Micelles Loaded with Asenapine Maleate
Zainab Eassa Jassim, Nawal Ayash Rajab, Hamid Akbari Javar
pp. s1461–s1473 · DOI: 10.5530/ijper.20263858 · Published 2026
Objectives: An effort has been utilized to incorporate ASPM into polymeric micelles using single and mixed copolymers. Materials and Methods: A thin-film hydration approach was used to create the ASPM polymeric micelles,…
Article
Evaluation of Commercial Lipstick Formulations for Compliance with BIS Standards: A Comparative Study
Deepak Sharma, Dipanjan Koley, Khushbu Mehlawat, Kavita Attri, Vijay Bhalla, Manvi Singh
pp. s1474–s1485 · DOI: 10.5530/ijper.20265022 · Published 2026
Background: The Indian cosmetic industry is experiencing rapid growth, valued at USD 8.1 billion in 2023 and projected to reach USD 18.4 billion by 2032. Among cosmetic products, lipsticks are widely used and frequently …
Article
Optimization of Palbociclib Nano Structured Lipid Carriers Loaded Transdermal Patch with Comprehensive ex vivo Skin Permeation and Retention Research for Management of Breast Cancer
Anilkumar Shinde, Nikita Gurav, Harinath More
pp. s1486–s1497 · DOI: 10.5530/ijper.20265560 · Published 2026
Background: Palbociclib (PCB), a selective cyclin-dependent kinase 4/6 prescribe for hormone receptor-positive breast cancer, has low oral bioavailability and dose-limiting systemic toxicity. Objectives: In order to achi…
Article
Deferoxamine Loaded Nanoemulgel for Enhanced Wound Healing: Formulation Optimization and in vivo Evaluation
Abdullah M. Alotaibi, Anroop B. Nair, Hiral Shah, Bandar Aldhubiab, Shery Jacob, Rashed M. Almuqbil, Ahmed S. Alnaim, Jigar N. Shah
pp. s1498–s1513 · DOI: 10.5530/ijper.20265633 · Published 2026
Background: Chronic wounds remain a major clinical challenge due to impaired angiogenesis, persistent inflammation, and oxidative stress, necessitating advanced therapeutic strategies. The purpose of this research was to…
Article
Cardioprotective Effect of Mikania micrantha Kunth Leaf Extract in Isoproterenol-Induced Myocardial Injury in Experimental Animals
Lamia Yasmin, Soumen Dhara, Surajit Ghosh, Satyaki Pachal, Sumit Jana, Dibya Das, Rania Indu, Moumita Ray
pp. s1514–s1522 · DOI: 10.5530/ijper.20262732 · Published 2026
Background: Myocardial Infarction (MI), driven by oxidative stress-induced cardiomyocyte injury, is the most predisposing disease, causing prevalent mortality globally, among the various cardiovascular diseases. Present …
Article
Therapeutic Potential of Phyllanthus niruri Against D-Galactosamine Induced Hepatitis in Wistar Strain Albino Rats: A Study with Reference to Oxidative Stress Markers and Antioxidant Enzymes
Bhasha Shanmugam, Kondeti Ramudu Shanmugam, Meesala Gurusekhar, Ramavath Kambli Naik, Dronadula Veena Madhuri, Sahukari Ravi
pp. s1523–s1531 · DOI: 10.5530/ijper.20262824 · Published 2026
Background: Phyllanthus niruri (PN), known as Bhumyamalaki and it has been used in Ayurveda to treat liver, kidney and spleen related disorders. But till date no study was carried on the antihepatitis activity of phenoli…
Article
Nano-Extracts of Green-Synthesized Curcuma longa: An Innovative Approach to Breast and Colorectal Cancer Prevention
Armugam Jayasankar, Hanumanthu Rama Subba Reddy, Marapa Reddy Sowghandika, Amgoth Govardhan Naik, Narasaiah Shivakoti, Paluru Subramanyam, Kanala Somasekhar Reddy, Devarapalle Veera Nagendra Kumar, Vempapti Uday Kiran
pp. s1532–s1543 · DOI: 10.5530/ijper.20263586 · Published 2026
Aim: Curcumin, the primary bioactive agent in Curcuma longa (turmeric), is celebrated in Ayurveda for its anti-inflammatory, antioxidant, and wound-healing effects. Its clinical application is limited by poor bioavailabi…
Article
Chromatographic and Spectroscopic Characterisation of Bioactive Compounds from Diplocyclos palmatus for Polycystic Ovary Syndrome Management
Richa Yadav, Jaya Parkash Yadav
pp. s1544–s1552 · DOI: 10.5530/ijper.20263948 · Published 2026
Aim: Polycystic ovary syndrome is a prevalent endocrine disorder that arises from hormonal imbalance, typically presenting with excessive androgen production, disrupted ovulatory cycles, and various metabolic abnormaliti…
Article
Cucurbitacin-B Triggers Fas/FasL-dependent Apoptosis via the Death Receptor Signalling Pathway in Human Breast Cancer Cell Line - MCF-7
Jawaher Amer Alsaiari, Abdulraheem A. Almalki, Jawaher Ayidh Alosaimi, Raja Mohammed Al-Qurashi, Bedour Abdullah Al-Qurashi, Fatima Anwar Dhafer, Ahad Amer Alsaiari
pp. s1553–s1562 · DOI: 10.5530/ijper.20264032 · Published 2026
Background: Globally, Breast Cancer (BC) ranks as the second most common cause of cancer-related death for women. The high mortality and recurrence rates contribute substantially to its fatality. Objectives: This researc…
Article
Phytochemical Profiling, Cytotoxicity, and Molecular Docking of Juglans regia L. Leaf Extracts for Potential Breast Cancer Therapy
Nael Abutaha, Fahd Abdo Al-Mekhlafi, Mohammed A. Wadaan
pp. s1563–s1572 · DOI: 10.5530/ijper.20263063 · Published 2026
Background: Juglans regia leaves contain bioactive compounds with potential anticancer effects. This study evaluated their cytotoxic activity and interactions with cancer-related targets. Materials and Methods: Leaves of…
Article
Formulation and Evaluation of Anxiolytic Activity of Nanogel of CSN1S2 Protein from Goat Milk
Sanjita Das, Shruti Dhasmana, Gyas Khan
pp. s1573–s1579 · DOI: 10.5530/ijper.20261810 · Published 2026
Objectives: This study is targeted at investigating the nanogel formulation of a protein from the milk of goat; CSN1S2 for anxiolytic activity in mice. Materials and Methods: After isolating CSNIS2, its nanogel was formu…
Article
Combating Neuroinflammation and Neurotoxicity with Curcumin-Piperine Nanoformulations
Mohammad Zubair Alam, Hala Abubaker Bagabir, Mohammad Alameen Faisal Zaher, Thamer Mohammed Ahmed Alqurashi, Badrah Saeed Alghamdi, Mohsin Kazi, Athanasios Alexiou, Ghulam Md Ashraf
pp. s1580–s1593 · DOI: 10.5530/ijper.20262042 · Published 2026
Background: Neuroinflammation plays a critical role in the progression of neurodegenerative diseases such as multiple sclerosis, Alzheimer's, and Parkinson's disease. The Cuprizone (CPZ)- induced model is widely used to …
Article
Cytotoxic and Apoptotic Study of Protocatechuic Acid Nanosuspensions Assessed by in silico Molecular Analysis and AO/EB Staining Technique
Navaneethakrishnan Subramanian, Vijayaraj Surendran, Rajkumar Selvam, Murugesan Vanangamudi, Thiruveni Azhagarsamy, Raghavendra Kumar Gunda
pp. s1594–s1603 · DOI: 10.5530/ijper.20263446 · Published 2026
Background: Bone cancer, particularly osteosarcoma, is an aggressive malignancy with poor prognosis, often resistant to conventional chemotherapy. Protocatechuic Acid (PCA), a plant-derived polyphenol, holds anticancer p…
Article
GI50 Inhibition Study Using Sulforhodamine B (SRB) Assay Method on Breast Cancer Cell Line (MCF-7) Using Ethanolic Extracts of Leaves of Chromolaena odorata and Capparis moonii
Urvashi Zamindar, Rajesh Khathuriya
pp. s1604–s1609 · DOI: 10.5530/ijper.20261302 · Published 2026
The study titled “GI50 inhibition study using Sulforhodamine B (SRB) assay method on breast cancer cell line (MCF-7) using ethanolic extracts of leaves of Chromolaena odorata and Capparis moonii” investigates the antican…
Article
Beyond Traditional Descriptors: Innovative Topological Indices for Enhanced Molecular Predictions
Veerappan Rajkumar, Balsubramanian Sivakumar, Savari Prabhu
pp. s1610–s1629 · DOI: 10.5530/ijper.20262805 · Published 2026
Aim/Background: In order to capture significant structural features of chemical compounds, this study presents three new topological indices: the Fragment-Weighted Connectivity Index (FWCI), the Distance-Weighted Subgrap…
Article
Optimising Metformin Degradation via Hydrodynamic Cavitation: A Comparative Study of Venturi and Orifice Devices Using Response Surface Methodology
Shital Prashant Dehankar, Ratnadip Rajabhau Joshi
pp. s1630–s1640 · DOI: 10.5530/ijper.20263968 · Published 2026
Background: The Hydrodynamic Cavitation (HC) is a promising, energy-saving method to remove micropollutants such as metformin in water. There are however difficulty in optimisation of the performance of HC reactor as the…
Article
Targeting Quorum Sensing-Mediated Virulence and Biofilm Formation in Pseudomonas aeruginosa Using Ferulic Acid
Khloud H Alsaadi
pp. s1641–s1649 · DOI: 10.5530/ijper.20260007 · Published 2026
Background: Pseudomonas aeruginosa is a clinically significant opportunistic bacterium that exhibits intrinsic antimicrobial resistance, biofilm formation, and quorum-sensing-regulated virulence. Nowadays, plant-derived …
Article
Adjunct Use of Pranic Healing Colours in Neuroprotection of SH-SY5Y Parkinson’s Disease Cell Models
Nagendra Prasad Krishnamurthy, Sanskruti Patil, Vinu Vijayakumar, Raghu Chandrashekar Hariharapura, Srikanth Nagaraja Jois
pp. s1650–s1656 · DOI: 10.5530/ijper.20264546 · Published 2026
Background: Parkinson’s Disease (PD) involves dopaminergic neurodegeneration associated with mitochondrial dysfunction, oxidative stress, and apoptosis. Objectives: To evaluate the effects of Pranic Healing (PH) colour e…
Article
Evaluation of the Anticancer Activity of Conessine against Human Melanoma (SK-MEL-28) Cells via Mitochondrial-Mediated Apoptotic Pathway
Yahya Hasan Hobani
pp. s1657–s1668 · DOI: 10.5530/ijper.20265707 · Published 2026
Background: Conessine is a steroidal alkaloid with diverse pharmacological activities, but its anticancer potential against melanoma and the mode of action remain poorly understood. Objectives: The present study evaluate…
Article
QbD-Driven RP-HPLC Method Development and Validation for Trigonelline Quantification in Fenugreek Seeds and Phytosomal Formulation
Akshay Kalgonda Patil, Abhishek Chandrashekhar Teli, Sachin Paragouda Gudasi, Adarsh Chidanand Umarani
pp. s1669–s1678 · DOI: 10.5530/ijper.20262187 · Published 2026
Background: Trigonelline is alkaloid known for its exceptional biological activities. The aim of the present work was to develop and validate Quality by Design based RP-HPLC method for estimation of trigonelline. Materia…
Article
Formulation and Evaluation of Mouth Dissolving Films of Sumatriptan Succinate Using Super Disintegrating Agent
Srishti Morris, Ashutosh Badola, Bhawana Kapoor, Nidhi Gairola
pp. s1679–s1687 · DOI: 10.5530/ijper.20262519 · Published 2026
Background: The purpose of this study was to formulate and evaluate Mouth-Dissolving Films (MDF) of Sumatriptan Succinate with super disintegrating agent Polacrilin Potassium, aimed at providing a fast and efficient deli…
Article
Optimization of Novel Topical Cubosomal Gel Containing Lidocaine Hydrochloride by Design of Experiment
Rajani Thoutreddy, Chakravarthi Guntupalli, Rajeshwari Pasupula, Anka Rao Areti, Pavani Sriram
pp. s1688–s1695 · DOI: 10.5530/ijper.20262598 · Published 2026
Background: Cubosomal gels have emerged as a favourable mode for delivery of drugs, contributing to release of drug in controlled mode with increased effectiveness. The study aimed to develop an optimized cubosomal gel f…
Article
Implementation of QbD Strategies for HPLC Cleaning Method Development and Validation of Cinacalcet in API and Dosage Form
Lalitha Repudi, Baby Nalanda Revu, Buggana Siva Jyothi, Raghavarapu Prasanthi, Vasanth P M, Swetha Sri Remidicherla
pp. s1696–s1706 · DOI: 10.5530/ijper.20263117 · Published 2026
Background: Cinacalcet HCl is used to treat hyperthyroidism and hypercalcisim. QbD approach used to assess risk and develop cleaning method for Cinacalcet HCl. The Method Operable Design Region (MODR) was obtained by CCD…
Article
Stability Indicating HPLC and HPTLC Method for Estimation of Letermovir
Mrinalini Damle, Akanksha Sujgure, Dipti Bhorade
pp. s1707–s1715 · DOI: 10.5530/ijper.20261791 · Published 2026
Aim: The aim of this study is to develop and validate High-Performance Thin-Layer Chromatography (HPTLC) and High-Performance Liquid Chromatography (HPLC) techniques for the quantification of Letermovir and its degradati…
Article
Development and Validation of a Simple and Robust Bioanalytical Method to the Quantification of Tafamidis in Human Plasma using LC-MS/MS
Shashipal Aitha, Subramani Devaraju, Kiran Kumar Tatapudi, Geereddy Mahesh Kumar Reddy, Tiruveedhula Somasekhar
pp. s1716–s1723 · DOI: 10.5530/ijper.20262396 · Published 2026
Objectives: Amyloid diseases are a rare class of disorders that have gained significant attention for therapeutic advancements. Among the key proteins implicated, transthyretin plays a central role in the progression and…
Article
Development and Validation of Comprehensive UV-visible Spectroscopy Method for Sensitive Detection of Nitrite Levels in Pharmaceuticals
Santosh Bhende, Nitin Pawar, Atul Phatak, Pravin Chaudhari
pp. s1724–s1731 · DOI: 10.5530/ijper.20262950 · Published 2026
Introduction: Nitrosamines are known to damage DNA and induce cancer, a characteristic that classifies them as genotoxic and carcinogenic. This research presents an innovative methodology designed for the quantification …
Article
Development and Validation of an HPLC Method for Simultaneous Quantification of Diosgenin and Piperine in Plasma using RP-HPLC
Sonal Sukhdeo Shaharwale, Nirmala Vikram Shinde
pp. s1732–s1739 · DOI: 10.5530/ijper.20263403 · Published 2026
Introduction: The present study aims to develop and validate a robust RP-HPLC method for the simultaneous estimation of Diosgenin and Piperine in human plasma. Materials and Methods: Chromatographic separation was achiev…
Article
Analytical Quality by Design-Based RP-HPLC Method for the Quantification and Stability Assessment of Nilotinib in Bulk and Nanoformulations
Rishabh Agade, Ujban Hussain, Divya Zambre, Sameer Sheikh, Veena Belgamwar
pp. s1740–s1754 · DOI: 10.5530/ijper.20264633 · Published 2026
Background: Nilotinib, a tyrosine kinase inhibitor of the second generation, is susceptible to stress-induced degradation that could undermine therapeutic effectiveness. Materials and Methods: The accelerated stability s…
Article
Regulatory Affairs Chatbot: Revolutionizing Compliance Through AI Integration
Maruveettil Arjun, Pranab Moudgil, Madhugiri Prakash Venkatesh
pp. s1755–s1764 · DOI: 10.5530/ijper.20264540 · Published 2026
Background: Regulatory requirements are becoming more complex and stringent due to recent developments in global standards. Most of the time, pharmaceutical companies opt for traditional and lengthy methods, however, the…
Article
In silico ADMET Study, Synthesis and Anticholinesterase Activity of 1,8-Naphthyridine Derivatives
Harsh Singh, Gopal Garg, Surya Prakash Gupta
pp. s1765–s1771 · DOI: 10.5530/ijper.20263005 · Published 2026
Background: This study aimed to synthesize 1,8-naphthyridine derivatives, conduct an in silico ADMET analysis, and evaluate the compounds' anti-cholinesterase activity in vitro. Materials and Methods: The Conrad-Limpach …
Article
Design, Optimization, and Characterization of Atorvastatin-Loaded Lipid-based Carriers for Enhanced Oral Bioavailability
Mohini Mondal, Biplab Debnath, Swarupananda Mukherjee, Tapan Kumar Shaw
pp. s1772–s1781 · DOI: 10.5530/ijper.20264022 · Published 2026
Aim: This study presents a dose reduction with sustained action and increased bioavailability. Atorvastatin (ATV) is the drug of choice for the management of hyperlipidemia, and the commonly available marketed product of…
Article
Method Development and Validation for the Simultaneous Estimation of Aflatoxins in Botanical Origin Samples Using High-Performance Thin-Layer Chromatography
Vaishnavi Chaudhari, Shraddha Bhor, Swati Lade, Milind Umekar, Sushil Burle, Radheshyam Lohiya, Diksha Undirwade
pp. s1782–s1794 · DOI: 10.5530/ijper.20265177 · Published 2026
Background and Objectives: Aflatoxins are toxic secondary metabolites produced by certain Aspergillus species and are frequently found in contaminated food and herbal products. Their presence poses serious health risks, …
Article
Optimization and Characterization of a Tofacitinib Citrate-Loaded Dermal Nanoemulgel for Rheumatoid Arthritis
Sayani Bhattacharyya, Raman Dang, Nikhath Fathima Muheeb, Sushma Ramanna, Kogileshwari Sivakumar
pp. s1795–s1806 · DOI: 10.5530/ijper.20265544 · Published 2026
Aim: Rheumatoid Arthritis (RA) is a progressive autoimmune disorder characterized by joint inflammation and functional disability. Conventional oral therapy with tofacitinib citrate exhibits poor bioavailability as it un…
Article
Formulation, Optimization, and in vivo Evaluation of Repaglinide-Loaded Solid Lipid Nanoparticles with Enhanced Bioavailability and Sustained Hypoglycemic Effect
Vedanshu Malviya, Shrikant Pande
pp. s1807–s1821 · DOI: 10.5530/ijper.20265191 · Published 2026
Background: Repaglinide is an oral antidiabetic agent which has inadequate water solubility and is highly first-pass metabolized (poor bioavailability 50-60%), thus necessitating frequent administration. Solid Lipid Nano…