Volume 53, Issue 2S

2019 · pp. s28–s42 · 24 articles

Volume: 53
Issue: 2S
Published: 2019
Pages: s28–s42
Articles: 24
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Recent Developments on Pharmacological Potential of 1,3,4-Oxadiazole Scaffold
Bhutani Rubina, Pathak Dharam P, Kapoor Garima, Kant Ravi, Dutta Manni
pp. s1–s16 · DOI: 10.5530/ijper.53.2s.44 · Published 2019
Heterocyclic compounds represent the important structural key in pharmaceutical medicinal chemistry. In literature, five-membered heterocycles are reported to be a core moiety of various pharmaceutical drugs. 1,3,4-oxadi…
Review
Mucoadhesive Nanoparticles: A Roadmap to Encounter the Challenge of Rapid Nasal Mucociliary Clearance
Chandrakantsing Vijaysing Pardeshi, Abhijeet Dattatraya Kulkarni, Raju Onkar Sonawane, Veena Shailendra Belgamwar, Prashant Jagannath Chaudhari, Sanjay Javerilal Surana
pp. s17–s27 · DOI: 10.5530/ijper.53.2s.45 · Published 2019
The modulation of mucoadhesion at the nanoscale is a very challenging task before the formulation scientists. Mucoadhesive nanoparticles are endowed with distinct properties such as increased residence, intimate contact …
Review
Sesamol and Health – A Comprehensive Review
Abhishek Shah, Richard Lobo, Nandakumar Krishnadas, Raviteja Surubhotla
pp. s28–s42 · DOI: 10.5530/ijper.53.2s.46 · Published 2019
Antioxidant potential of sesamol has led to being studied extensively in recent decades for its beneficial role in vast aliments. There has been a renewed interest in this compound recently, due to its activities such as…

Original Article

Article
Novel Preparation and Effective Delivery of Mucoadeshive Nanoparticles Containing Anti-diabetic Drug
Sree Harsha Nagaraja, Bandar E Al-Dhubiab, Rakesh Kumar Tekade, Katharigatta Narayanaswamy Venugopala, Ravindra Vasant Ghorpade, Girish Meravanige, Ahmed Alqadheeb
pp. s43–s49 · DOI: 10.5530/ijper.53.2s.47 · Published 2019
Background: Vildagliptin is an extensively studied DPP-4 inhibitors (anti-diabetic drug) which has contributed greatly to the understnading of molecular interatcion with the DPP-4 enzyme. However, Vildagliptin exerts glu…
Article
Formulation and Characterization of Controlled Release Flurbiprofen Microsponges Loaded in Gels
Ankita Vernekar, Rajashree Gude, Nidhi Ghadi, Steffi Parab, Akshata Shirodker
pp. s50–s57 · DOI: 10.5530/ijper.53.2s.48 · Published 2019
Objective:The main objective of this study was to formulate transdermal gels containing Flurbiprofen microsponges for controlled drug delivery. Methods: Microsponges containing Flurbiprofen and ethylcellulose were prepar…
Article
Effect of Sustained Release Polymers on Drug Release Profile of Aceclofenac TabletsPhysicochemical Properties, Analysis of Kinetics and Fit Factor
Uzair Nagra, Sherjeel Adnan, Sana Shafqat, Maryam Shabbir, Sajid Ali, Anum Zafar, Syed Saeed ul Hassan, Javed Iqbal
pp. s58–s65 · DOI: 10.5530/ijper.53.2s.49 · Published 2019
Aim: The sustained release tablets of Aceclofenac were prepared and evaluated for the sustained release drug profile with an aim to reduce dosing frequency and provide patient compliance. Materials and Method: The tablet…
Article
Sustained Release Bioadhesive Ocular Inserts of Olopatadine Hydrochloride: Formulation and Characterization
Vidya Sabale, Omprakash Nanalaji Kumawat, Prafulla Madhukarrao Sabale
pp. s66–s73 · DOI: 10.5530/ijper.53.2s.50 · Published 2019
Objective: To develop bioadhesive ocular inserts of Olopatadine hydrochloride for treating the allergic eye conditions with sustained ocular delivery which will reduce dosing frequency. Methods: Matrix type ocular insert…
Article
Formulation, Development and Evaluation of Nifedipine Emulgel for Treatment of Anal Fissures using Polymeric Emulsifiers
Om Shelke, Amol Kulkarni
pp. s74–s81 · DOI: 10.5530/ijper.53.2s.51 · Published 2019
Aim/Background: Nifedipine (NIF) is act as Calcium channel blocker which belongs to chemical class dihydropyridine and used in the treatment of hypertension. An anal fissure (AF) is the most common anorectal conditions e…
Article
Piroxicam Loaded Solid Lipid Nanoparticles (SLNs): Potential for Topical Delivery
Harshita Krishnatreyya, Sanjay Dey, Paulami Pal, Pranab Jyoti Das, Vipin Kumar Sharma, Bhaskar Mazumder
pp. s82–s92 · DOI: 10.5530/ijper.53.2s.52 · Published 2019
Aim: The objective of this study was to develop suitable lipid nanocarriers for topical delivery of Piroxicam, known for its anti-inflammatory and anti-arthritic properties and to increase its therapeutic potential and r…
Article
Formulation and Evaluation of Gastro-bilayer Floating Tablets of Ezetimibe as Immediate Release Layer and Atenolol as Sustained Release Layer
Ranjit Prasad Swain, Avasarala Nagamani, Panchagnula Udaya Shankar
pp. s93–s103 · DOI: 10.5530/ijper.53.2s.53 · Published 2019
Introduction: Combination therapy of ezetimibe and atenolol is highly desirable for better management of dyslipidaemia and hypertension. Ezetimibe has poor solubility hence variable and low bioavailability. Atenolol has …
Article
Medhya Rasayana Restores Memory Function against Doxorubicin-induced Cognitive Decline: Possibly by its Neuroprotective Effect
Karthik Gourishetti, Sawan Ghetia, Ligin Jacob, Sanchari Basu Mallik, Pawan Ganesh Nayak, Anoop Kishore, Krishnadas Nandakumar, Sulaiman Mohammed Alnaseer, Shalam Mohamed Hussain
pp. s104–s111 · DOI: 10.5530/ijper.53.2s.54 · Published 2019
Background: Medhya Rasayana (MR) is an ayurvedic formulation used to rejuvenate the intellectual functions. It was shown to improve the cognitive function in rats. Hence, the present study was designed to study the neuro…
Article
Biosynthesis, Characterization and Antagonistic Applications of Extracellular Melanin Pigment from Marine Nocardiopsis Sps
Neethu Kamarudheen, Thahiya Naushad, Kokati Venkata Bhaskara Rao
pp. s112–s120 · DOI: 10.5530/ijper.53.2s.55 · Published 2019
Context:Although there is an abundance of several microbial phyla in the oceans actinobacteria have emerged as a major source for natural products. Streptomyces sps is the widely encountered actinobacteria. Lately, Strep…
Article
Formulation, Optimization and Evaluation of in-situ Gelling Liquid Oral Formulation of a Novel Antidiabetic Drug: Canagliflozin
Rohith Ganapathi Bhatta, Sadashivaiah Rudragangaiah, Satheesha Babu Birur Kotappa
pp. s121–s128 · DOI: 10.5530/ijper.53.2s.56 · Published 2019
Aim: The present research work involves the development and optimization of an in-situ gel forming formulation by face centered central composite response surface design methodology to increase buoyancy and controlled re…
Article
Synthesis and Characterization of Novel N-Benzylbenzimidazole Linked Pyrimidine Derivatives as Anticancer Agents
Gopal Krishna Padhy, Jagadeesh Panda, Ajaya Kumar Behera
pp. s129–s134 · DOI: 10.5530/ijper.53.2s.57 · Published 2019
Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and…
Article
The Effectiveness of Chitosan- Pinus merkusii Extract Nanoparticle as Antioxidant and Anti-caspase 3 in against Lead Acetate Toxicity on the Lung of Wistar Rat
Sri Agus Sudjarwo, Giftania Wardani, Koerniasari Eraiko, Koerniasari Koerniasari, Ernawati Ernawati
pp. s135–s142 · DOI: 10.5530/ijper.53.2s.58 · Published 2019
Background: The antioxidants can be used for protective in oxidative stress that is one of the important mechanisms of lead acetate-induced lung toxicity. Objective: The current study was carried out to evaluate the effe…
Article
Structure Based Computational Exploration of Beilschmiedia Compounds with Selected Targets against Multidrug-Resistant Mycobacterium tuberculosis
Mohammad Yasir, Pushpendra Singh, Sunidhi Chohan, Rahul Shrivastava
pp. s143–s150 · DOI: 10.5530/ijper.53.2s.59 · Published 2019
Aim/Background: Tuberculosis is a serious health issue across the world. Various bioactive molecules show the affects against Multidrug-resistant tuberculosis (MDR-TB). There are various standard drugs developed against …
Article
18β-glycyrrhetinic Acid Protects against Staphylococcus aureus Infection by Regulating the NF-κB Pathway
Chunhui Rao, Zhuping Hong, Yuanyuan Yao, Gang Zheng, Saisai Wang
pp. s151–s158 · DOI: 10.5530/ijper.53.2s.60 · Published 2019
Background: 18β-glycyrrhetinic acid (18β-GA) is reported to possess various pharmacological properties of which anti-inflammatory activities has been widely explored. However, the role of 18β-GA in Staphylococcus aureus …
Article
Development and Evaluation of Polyherbal Lozenges for Cold and Flu
Anshul Kumar, Manish Kumar Mishra, Afeefa Afeefa, Chandrashekar K.S, Girish Pai, Vasudev Pai
pp. s159–s163 · DOI: 10.5530/ijper.53.2s.61 · Published 2019
Background: Lozenges are solid dosage form which are intended to slowly dissolve in the mouth for therapeutic effect. Common cold and flu are common diseases which usually infects the respiratory tract including symptoms…
Article
Total Phenolic and Caffeic Acid Contents in Roots of Solanum indicum L. from Different Agroclimatic Regions of Madhya Pradesh State of India
Hari Om Saxena, Ganesh Pawar
pp. s164–s169 · DOI: 10.5530/ijper.53.2s.62 · Published 2019
Introduction: Solanum indicum L. is one of the species of Dashmularishta, a wellestablished ayurvedic medicine used in the treatment of fatigue, oral sores and gynecological disorders. The present investigation dealt wit…
Article
Simultaneous Determination of Hydrophilic and Lipophilic Drugs in Anti-Cancer Liposomes: Absorptivity Method
Harshita Mishra, Pawan Kumar Mishra, Manu Jaggi, Zeenat Iqbal, Sushama Talegaonkar
pp. s170–s178 · DOI: 10.5530/ijper.53.2s.63 · Published 2019
Background: Dual loaded liposomes have always been a hot topic of investigation because of their therapeutic advantages over single drug regimens. But simultaneous estimation of both the drugs during in vitro and in vivo…
Article
In vitro Metabolism of Risperidone on Isolated Microsomes of Rat Liver: Metabolite Identification and Profiling by RP-HPLC and LC-MS Techniques
Prutha Shirodkar, Harshal Chavan, Rajendra Mogal, Avinash Dhake
pp. s179–s185 · DOI: 10.5530/ijper.53.2s.64 · Published 2019
Objective: The objective of present research work is to study in vitro metabolism of risperidone on isolated microsomes of rat liver. Methods: Its biotransformation was examined using isolated microsomes derived from rat…
Article
EPR and UV-Vis Spectroscopic Studies of the Influence of Ultraviolet Irradiation on Antioxidant Interactions of Nystatin
Paweł Ramos, Barbara Pilawa, Piotr Pepliński
pp. s186–s192 · DOI: 10.5530/ijper.53.2s.65 · Published 2019
The changes of the free radical scavenging activity of nystatin after UV-irradiation were examined. The kinetics of the interactions of nystatin with free radicals was tested. The model DPPH free radicals were used. Free…
Article
Screening of Silk Fibroin as a Stabilizer for Freeze Drying of Thermolabile Drug
Pooja Gajanan Mirajkar, Ashok Ananda Hajare
pp. s193–s203 · DOI: 10.5530/ijper.53.2s.66 · Published 2019
Aim: In the present research work an attempt is made to investigate use of silk fibroin as a stabilizer for model thermolabile drug Tenofovir Alafinamide Fumarate (TAF). Materials and Methods: On the basis of literature …
Article
Development and Evaluation of a (SEDDS) SelfEmulsifying Drug Delivery System for Darifenacin Hydrobromide
Nagaraja SreeHarsha, Arshia Shariff, Yogesh A Shendkar, Bandar E. Al-Dhubiab, Girish Meravanige
pp. s204–s212 · DOI: 10.5530/ijper.53.2s.67 · Published 2019
Background: The formulation and development of new chemical entities has the major challenge of low solubility. A fraction of newly manufactured drugs (40%) have poor hydrophilicity. As a result, the delivery of these dr…