Volume 56, Issue 2S

2022 · pp. S326–S338 · 25 articles

Volume: 56
Issue: 2S
Published: 2022
Pages: S326–S338
Articles: 25
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Drug Repurposing: A Potentially Emerging Discipline
Praveen Kumar, Mariam Mammen, Aswathy Madhusoodhanan, Archana Geetha Mohanan, Pradeep Kumar Ravindrannair, Anilkumar Appu Kuttan, Sheeba Madhavan Sathi, Mathew Steephan
pp. S121–S136 · DOI: 10.5530/ijper.56.2s.83 · Published 2022
Drug repurposing is the remodeling of already existing drugs to reduce the time frame, costs, and efforts in developing a new novel drug. This strategy has secured significant momentum in the previous decade. It overcome…
Review
The Benefits and Barriers of Patenting: How Academicians and Researchers Can use their IP to Improve Research Outcomes: An Indian Perspective
Jobin Jose, Abdul Haseeb K, Anu Jose, Shifali S, Simi P Thomas, Prasant Nayak
pp. S137–S145 · DOI: 10.5530/ijper.56.2s.84 · Published 2022
Patent protection is the exclusive rights to protect the invention which forbid the manufacture, use, distribution or trade of the invention by others unless they get permission from the patentee. Patent is granted to th…

Original Article

Article
Box-Behnken Design Assisted Optimization and Standardization of Chromatographic Methodology for Quality Assessment of Metformin: Analytical Quality by Design Avenue
Shailendra S Suryawanshi, Mahesh S Palled
pp. S152–S162 · DOI: 10.5530/ijper.56.2s.86 · Published 2022
Background: Metformin (MET) is an oral antidiabetic agent falls chemically under the category of biguanides and it is effectively utilized in the management of type 2 diabetes mellitus. It is marketed in the tablet dosag…
Article
Formulation and Evaluation of Topical Preparations Containing Pyrolytic Oil Obtained from Local Biomass
Jithu Jerin James, Sandhya Kadamboor Veethil, Joysa Ruby Joseph Rajarathinam
pp. S163–S170 · DOI: 10.5530/ijper.56.2s.87 · Published 2022
Objectives: Pyrolytic oil of coconut shell was obtained by the fast pyrolysis method. This research aimed to identify the use(s) of pyrolytic oil in topical pharmaceutical formulations. The study included extraction of b…
Article
Artemether and Lumefantrine Loaded Self-nanoemulsifying drug Delivery System for Enhancement of Bioavailability
Rao Monica Raghavendra Prasad, Pardeshi Amol A
pp. S171–S180 · DOI: 10.5530/ijper.56.2s.88 · Published 2022
Introduction: This study involves development and evaluation of bioavailability of oral self-nanoemulsifying drug delivery system of BCS class II and IV drugs, Artemether and Lumefantrine (AL), respectively. This fixed c…
Article
Forced Degradation Study of Sofosbuvir: Identification of Degradation Products by LC-ESI-MS
Babita Agarwal, Sachin Jagdale, Santosh Gandhi
pp. S181–S188 · DOI: 10.5530/ijper.56.2s.89 · Published 2022
Introduction: In order to establish stability indicating techniques to comprehend the degradation behavior of drug under stress environments and to establish degradation pathway for drug substance, forced degradation is …
Article
Development Optimization and Cytotoxicity Evaluation of Glyburide Loaded Nanostructured Lipid Carriers
Ashwini M, Preethi Sudheer, Bharani S. Sogali, Chandramouli R
pp. S189–S199 · DOI: 10.5530/ijper.56.2s.90 · Published 2022
Aim/Background: In the present study Glyburide, a hypoglycaemic agent was loaded into nanostructured lipid carriers. The solid and liquid lipid concentrations within the formulation were optimized using central composite…
Article
Formulation Development and Optimization of Bioenhanced Sublingual Tablets of Rizatriptan Benzoate to Combat Migraine
Manish Kumar Singh, Rupa Mazumder, Swarupanjali Padhi, Dinesh Kumar Singh
pp. S200–S215 · DOI: 10.5530/ijper.56.2s.91 · Published 2022
Introduction: The drugs belonging to BCS class III, create various challenges for the development of sublingual dosage form due to poor absorption through sublingual mucosa. The sublingual drug delivery is suitable for p…
Article
Development and in vitro Evaluation of Atazanavir Microcrystals for Intranasal Delivery
Swarnali Das Paul, Rohitas Deshmukh, Simran Kukreja
pp. S216–S224 · DOI: 10.5530/ijper.56.2s.92 · Published 2022
Background: Nasal route of drug administration has gained popularity nowadays specially for drugs acting on nasopulmonary area. Atazanavir is an antiviral drug which has proved efficacy in different viral infection inclu…
Article
Formulation, Optimization and Evaluation of Ticagrelor Loaded Self Microemulsifying Chewable Tablets
Veerendra K M, Rajashree S Masareddy, Archana S Patil, Udaykumar Bolmal
pp. S225–S234 · DOI: 10.5530/ijper.56.2s.93 · Published 2022
Ticagrelor is a new generation Adenosine diphosphate receptor inhibitor drug which is highly lipohilic having poor aqueous solubility used in the treatment of Acute Coronary Syndrome and prevention of Thrombotic events l…
Article
Central Composite Design for the Development and Evaluation of Liquisolid Compacts of Glyburide
Archana Patil, Bhakti Kauthankar, Satish Kavatagimath, Rajashree Masareddy, Panchaxari Dandagi
pp. S235–S244 · DOI: 10.5530/ijper.56.2s.94 · Published 2022
Background: Glyburide is an oral antidiabetic agent with a shorter half-life and is practically insoluble in water. As a result, there is a need to enhance the drug solubility with a aim to improve drug absorption via th…
Article
Novel Formulation for Facial Acne using Liposomal Gel Containing Lipid Soluble Naphthoic Acid Derivative
Ankita Patel, Richa Dayaramani
pp. S245–S252 · DOI: 10.5530/ijper.56.2s.95 · Published 2022
The first line therapies in many acne diagnoses include application of retinoic acid derivatives for improvement in acne severity. Though, it has been observed that, current available formulations are sensitive to skin a…
Article
Effect of Solutol HS 15 and Cremophor RH 40 on Dissolution and Bioavailability of Nateglinide through Solid Dispersions
Ranjit Prasad Swain, Bharat Bhusan Subudhi
pp. S253–S264 · DOI: 10.5530/ijper.56.2s.96 · Published 2022
Introduction: To improve the aqueous solubility and bioavailability of nateglinide, we have earlier used poloxamer 188 and 407. Since solutol HS 15 and cremophor RH 40 are compatible and scalable polymers for industrial …
Article
Acute Dermal and Ocular Irritation Testing of Herbal Shampoos in New Zealand White Rabbits
Madhusudhan Meka, Krishnaji Rao Mutyala, Radha Gadela, Ganapathy Seru
pp. S265–S273 · DOI: 10.5530/ijper.56.2s.97 · Published 2022
Aim: The objective of the presented study is to evaluate the acute dermal and ocular irritation of herbal shampoos consisting of a mixture of plant extracts. Materials and Methods: Both studies performed using New Zealan…
Article
Epimedii folium Polysaccharide Ameliorated Glucose Metabolic Disorder in Type 2 Diabetic Mice by Regulating the SIRT1/PPARγ Signaling Pathway
Ruo-Fei Huang, Lin-Lin Xu, Tian-Xi Chen, Ke Li, Jing-Yao Xia, Hui-Shang Wang
pp. S274–S280 · DOI: 10.5530/ijper.56.2s.98 · Published 2022
Background and Aim:Epimedii folium is a widely used herbal medicine with numerous medicinal effects. In this study, we aimed to investigate the effects of Epimedii folium polysaccharide (EFP) in db/db metabolic disorder …
Article
Comparative Assessment of the Effect of Lemongrass (Cymbopogon citratus) Ethanolic Extract, Aqueous Extract and Essential Oil in High Fat Diet and Fructose Induced Metabolic Syndrome in Rats
Swati Dobhal, Mamta F Singh, Sonal Setya, Shradha Bisht
pp. S281–S293 · DOI: 10.5530/ijper.56.2s.99 · Published 2022
Background: Lemongrass (Cymbopogon citratus) is widely used as a folklore medication for treating obesity and diabetes. The present study evaluates the comparative effect of ethanolic and aqueous extract and essential oi…
Article
Phytochemical Characterization of Argemone mexicana Leaf Extracts: An Evidence for its Antiandrogenic and Antioxidant Activities
Jayapal Sharath, Rafi Ahmed Shahin Taj, Mahadevaiah Bhagya
pp. S294–S302 · DOI: 10.5530/ijper.56.2s.100 · Published 2022
Introduction: The naturally available herbs are used for medicinal purpose to promote health. The leaves of Argemone mexicana is one such herb used against different ailments. However, studies involving the characterizat…
Article
Investigation of Memory Enhancing Activity of Madhuca longifolia Leaf Extract against Colchicine: An Experimental Study and Biochemical Alterations in Mice
Pragati Khare, Kamal Kishore, Dinesh Kumar Sharma
pp. S303–S311 · DOI: 10.5530/ijper.56.2s.101 · Published 2022
Objectives: The present study aimed at investigating the protective role of Madhuca longifolia ethanolic leaf extract flavonoid fraction against colchicine induced cognitive dysfunction and oxidative damage in swiss albi…
Article
Investigation of Biological, Scolicidal and Antimicrobial Activities of the Solvent Extracts Components of Cystoseria barbata Seen off Sinop Province
Ulku Karaman, Tayyibe Beyza Yucel, Tugba Cebeci, Yeliz Kasko Arici, Murat Yucel, Busra Korkmaz
pp. S312–S325 · DOI: 10.5530/ijper.56.2s.102 · Published 2022
Aim/Background: Seaweeds are unicellular or multicellular vegetative organisms and have a wide distribution. Their antitumoral, antiviral, antifungal, insecticidal, cytotoxic, and phytotoxic and antiproliferative activit…
Article
Murraya koenigii Extract Loaded Phytosomes Prepared using Antisolvent Precipitation Technique for Improved Antidiabetic and Hypolidemic Activity
Anjna Rani, Sunil Kumar, Roop K Khar
pp. S326–S338 · DOI: 10.5530/ijper.56.2s.103 · Published 2022
Background: Phytosome is a novel technique introduced by Indena that combines standardised herbal extract and phospholipid in preferably equal ratio to provide better absorption enhancing bioavailability. Purpose: The ob…
Article
Validated High Performance Liquid Chromatography Method for the Quantification of Loteprednol Etabonate in Self Micro Emulsifying Drug Delivery Systems
Prem Prakash Singh, Srividya Gorantla, Ranendra N Saha, Gautam Singhvi
pp. S339–S346 · DOI: 10.5530/ijper.56.2s.104 · Published 2022
Background: The objective of this work is to develop and validate a reverse-phase HPLC method for determining Loteprednol Etabonate in self micro emulsifying drug delivery systems at nanogram level. Methods: A systematic…
Article
Research on Pharmaceutical Product Life Cycle Management Challenges Faced by Generic Manufacturers for US Approval
Murthannagari Vivek Reddy, Gonna Nandhi Krishnan Ganesh, Syed Suhaib Ahmed, Praharsh Kumar Mandadhi Rajendra, Eknath Babu
pp. S347–S355 · DOI: 10.5530/ijper.56.2s.105 · Published 2022
Introduction: Generic drug approval before patent expiration involves patent infringement petitions due to robust Life Cycle Management (LCM) strategies followed by Branded companies. They will extend the patent period o…
Article
Vaccine Safety and Surveillance for Adverse Events Following Immunization (AEFI) for COVID-19 Vaccine in a Tertiary Care Hospital-Kerala
Dilip Chandrasekhar, Mohammed Salim Karattuthodi, Linu Mohan Panakkal, Angel Mary William, Anjana A, Annmaria Benny, Aqila Karuppam, Beneta Sarah Sam, Shinu Cholamugath, Jaffer Chalil Parambil, Aneesh Puthiyedath Joy
pp. S356–S364 · DOI: 10.5530/ijper.56.2s.106 · Published 2022
Introduction: The meteoric spread of COVID-19 had facilitated the researchers to develop vaccines. One among the most recommended, Covishield requires further investigations for lighting up the society towards the immuni…
Article
A 32 Factorial Design Approach for Formulation and Optimization of Azilsartan Medoxomil Nanosuspension for Solubility Enhancement
Nitin Shirsath, Dipak Marathe, Priyanka Jaiswal, Laxmikant Zawar
pp. S365–S373 · DOI: 10.5530/ijper.56.2s.107 · Published 2022
Background: Azilsartan medoxomil (AZL) is an orally active nonpeptide angiotensin II receptor antagonist with less water solubility and oral bioavailability. Objectives: Increase the solubility and dissolving rate of AZL…
Article
Team-Based Learning Approach for the Delivery of Over-the-counter Module in the Faculty of Pharmacy in Jordan
Haneen A Basheer, Mohammad Isreb, Yazan S Batarseh, Simon Tweddell
pp. · DOI: 10.5530/ijper.56.2s.85 · Published 2022
Team-based learning is an active learning strategy that focuses on student’s engagement, development of critical thinking, and transferable skills needed in the workplace. While many pharmacy faculties around the world h…