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International Journal of Pharmaceutical InvestigationNOW IN
Article

Design and Development of Chitosan Beta-cyclodextrin based Nasal Mucoadhesive Microspheres of Clarithromycin

Subramanaian Rajarajan1★, B Prakash Rao2, S Selvamuthukumar1★ Corresponding author

  1. 1Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.
  2. 2Department of Pharmaceutical Technology, Karnataka College of Pharmacy, Bangalore, Karnataka, INDIA.

CORRESPONDENCE

Subramanaian Rajarajan

Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.

pharmking@gmail.com

Received: 24-07-2020; Revised: 20-08-2020; Accepted: 15-09-2020.

Volume 10, Issue 3 · pp. 279–285 · PUBLISHED · DOI: 10.5330/ijpi.2020.3.51

View on IJPI original site ↗

ABSTRACT

Objectives: The present systematic research is to design, develop clarithromycin nasal mucoadhesive microspheres for the utilisation in respiratory tract infection as alternative route of drug delivery. Methods:Current study designed to formulate, evaluated by using chitosan, beta cyclodextrin with modified emulsion lyophilisation method. 24 factorial design was used in optimization technique. Characterisation of prepared microspheres will be subjected for particle size and size distribution, drug entrapment study, in vitro drug diffusion studies and ex vivo mucoadhesion, surface morphology, zeta potential, infra-red radiation, differential scanning calorimetry, X-ray diffraction and stability studies. Results: The optimised formulation of predicted values of chitosan 0.604, Beta cylclodextrin 0.7633, Propeller Mixing Speed 9369 and Lyocycle temperatue of -42.8°C, Particle Size 14.06 µm, Entrapment efficiency 73.32%, Mucoadhesion 81.03 % and Maximum drug release 80.56%. Other finding results were satisfactory in control of quality attributes. Conclusion: Developed microspheres can be potential highlight on utilisation of clarithromycin as nasal drug delivery with beneficial as alternative dosage form for respiratory tract infections.

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    Rajarajan, S., Rao, B. P., & Selvamuthukumar, S. (). Design and Development of Chitosan Beta-cyclodextrin based Nasal Mucoadhesive Microspheres of Clarithromycin. International Journal of Pharmaceutical Investigation, 10(3), 279–285. https://doi.org/10.5330/ijpi.2020.3.51