Volume 10, Issue 3

· pp. 233–416 · 29 articles

Volume: 10
Issue: 3
Published
Pages: 233–416
Articles: 29
Sections: 2
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article

In this issue

Review Article

Review
Three Dimensional Printing by Hot-Melt Extrusion; New Era for Development of Personalized Medicines and Continuous Manufacturing of Pharmaceuticals
Amit Chivate, Atul Garkal, Namdev Dhas, Tejal Mehta
pp. 233–236 · DOI: 10.5330/ijpi.2020.3.43 · Published
The three-dimensional printing is a growing field in engineering, civil constructions and pharmaceutical development. The three-dimensional printing is a one-step continuous process. However, conventional manufacturing i…
Review
Microsponges: A de novo Method for Colon Targeted Oral Drug Delivery
Kuralla Hari, Sunkara Sai Prathyusha, Gokavarapu Vasavi
pp. 237–245 · DOI: 10.5330/ijpi.2020.3.44 · Published
Colon Targeted Oral Drug Delivery System has gained much importance in recent times in delivering drug substance for the local action against colonic cancers, infections, Ulcerative Colitis (UC) and Crohn’s disease and f…
Review
Pharmaceutical Co-crystals: A Systematic Review
Puneeth Jayram, Preethi Sudheer
pp. 246–252 · DOI: 10.5330/ijpi.2020.3.45 · Published
Low aqueous solubility and concomitant oral bioavailability are the major glitches found in converting the active pharmaceutical ingredients to new pharmaceutical products. Many methods are in existence to improve the so…
Review
Nanostructured Lipid Carriers (NLC): A Targeting Approach to the Brain via Intranasal Administration
Swatantra Kumar Singh Kushwaha, Neelottama Kushwaha, Bushra Fatma, Piyush Pandey
pp. 253–256 · DOI: 10.5330/ijpi.2020.3.46 · Published
Different barriers like a blood-brain barrier in the brain restrict the transport of potential therapeutic elements for direct entry into the brain. For delivery of a wide range of therapeutic drugs directly to the brain…
Review
A Review On Regulatory Requirements To Prevent Counterfeit Drugs In India
Mourya Mamtashanti, Jadav Rahul, Thummar Kashyap
pp. 257–262 · DOI: 10.5330/ijpi.2020.3.47 · Published
Counterfeit drugs are a serious issue nowadays, which has been burdening for developing countries and has a significant impact on the health of people. The Indian drug regulatory agency has published the details of the c…
Review
Regulatory Requirements and Innovation: A Comparison of Stability Study in the United States Food and Drug Administration (USFDA) and the Gulf Cooperation Council (GCC)
Reshma Pushpa Murali, Lovely Joylen Castelino, Ravi Gundadka Shriram, Akhilesh Dubey
pp. 263–267 · DOI: 10.5330/ijpi.2020.3.48 · Published
Stability studies form a crucial aspect of the pharmaceutical development process and play a vital role in establishing the quality, safety and efficacy of the drug product. The core objective of a stability study is to …

Original Article

Article
Bioinorganic Chemistry of Co (II) and Mn (II) Complexes
Vinay Kumar Srivastava
pp. 268–272 · DOI: 10.5330/ijpi.2020.3.49 · Published
Objectives: Schiff base ligand 2-thio phenyl glyoxal anthranilic acid is used as the starting material for the synthesis of many biologically active compounds. The main objectives of the Study was to synthesize, characte…
Article
Homology Modelling and in silico Characterization of Laccase from Lentinula edodes
Vemula Vani, Jayashree D J, Navya K S, Akanchha A, Syeda Tanzeela Zaman
pp. 273–278 · DOI: 10.5330/ijpi.2020.3.50 · Published
Introduction: Laccases are phenol oxidases which belong to the superfamily of multicopper oxidases. Laccases are found in almost all wood-rotting fungi. There is evidence that laccases can play an important role in ligni…
Article
Design and Development of Chitosan Beta-cyclodextrin based Nasal Mucoadhesive Microspheres of Clarithromycin
Subramanaian Rajarajan, B Prakash Rao, S Selvamuthukumar
pp. 279–285 · DOI: 10.5330/ijpi.2020.3.51 · Published
Objectives: The present systematic research is to design, develop clarithromycin nasal mucoadhesive microspheres for the utilisation in respiratory tract infection as alternative route of drug delivery. Methods:Current s…
Article
Quality by Design (QbD) Approach for Optimization and Characterization of Micro emulsion based Nasal formulation of Antipsychotic/Antischizophrenic Drug- Aripiprazole
Sharada L Deore, Bhushan A Baviskar, Anjali Kide, Ashwin D Deshmukh, Yogita B Khandare, Ramdas B Rode
pp. 286–293 · DOI: 10.5330/ijpi.2020.3.52 · Published
Introduction:Present study is focused to develop micro emulsion based nasal formulation of poorly water soluble antipsychotic/anti-schizophrenic drug Aripiprazole. Materials and Methods:Different surfactants and co surfa…
Article
Formulation and Evaluation of Hydrocortisone Sodium Succinate Mucoadhesive Buccal Tablet
Mohammad Ali Daneshmehr, Hilda Adibpour, Zahra Ataie
pp. 300–304 · DOI: 10.5330/ijpi.2020.3.54 · Published
Background: The present study involves the formulation and in-vitro assessment of mucoadhesive tablets of hydrocortisone sodium succinate. Local treatment for buccal inflammatory injuries such as aphthous wounds relies o…
Article
A Smart Approach for Delivery of Nanosized Phenytoin using Biomaterial Isolated from Fragaria ananassa
Sushant Kumar, Nookala Venkala Satheesh Madhav, Anurag Verma, Kamla Pathak
pp. 305–311 · DOI: 10.5330/ijpi.2020.3.55 · Published
Objectives: The bionanosuspension was prepared by using the isolated biopolymer from Fragaria ananassa fruit which serve as a potential, natural polymeric nature biomaterial. The isolated biomaterial was used for the pre…
Article
Green Synthesis of Silver Nanoparticles by using Stem, Leaves and Fruits Extracts of Umber (Ficus racemosa)
Kadam Sneha D, Shinde Sarika P, Chavan Tejonmayi S, Phatake Yogesh B, Mane Sneha G, Dhawan Shivanjali S, Marathe Rajendra J, Deshmukh Rajkumar B, Dharmadhikari Smita M
pp. 312–319 · DOI: 10.5330/ijpi.2020.3.56 · Published
Objectives:In this study, silver nanoparticles (AgNPs) were synthesized using healthy plant parts like fruits, stem and leaves of Ficus racemosa. Methods: The collected plant samples were processed by cleaning, drying an…
Article
Film Forming, Antimicrobial and Growth Promoting Wound Healing Spray Formulation
Rupali Kale, Dattatray Doifode, Pratiksha Shete
pp. 320–325 · DOI: 10.5330/ijpi.2020.3.57 · Published
Background: Bacterial infections at wound site are one of the major causes for delayed healing. The aim of this study was to develop topical film forming spray having Combination of Simvastatin and Mupirocin which can av…
Article
Mebeverine Hydrochloride Loaded Chitosan Microspheres as Potential Treatment Targeting Irritable Bowel Syndrome: Box-Behnken Design Optimization
Azza Ali Hasan, Rasha Mohamed Samir, Samir Sayed Abu-Zaid, Amr Selim Abu Lila
pp. 326–331 · DOI: 10.5330/ijpi.2020.3.58 · Published
Objective: Mebeverine hydrochloride is an antispasmodic agent that has a direct musculotropic action on the smooth muscles of the gastrointestinal tract; especially the colon.Therefore, the current study aimed at formula…
Article
Silibinin Loaded Solid Lipid Nanoparticles: Effect of Different Lipids and Surfactants on Physicochemical Properties of Nanoparticle
Priya Patel, Mihir Raval, Navin Sheth
pp. 332–338 · DOI: 10.5330/ijpi.2020.3.59 · Published
Background: Solid lipid nanoparticles are rapidly developing field of nanotechnology with several potential applications in drug delivery with spherical shape and an average diameter between 1 and 1000 nm. Due to their s…
Article
Adsorption Equilibrium and Thermodynamic Studies of Ciprofloxacin from Aqueous Solutions by Magnetic Bentonite Nanocomposites
Davoud Balarak, Marzieh Baniasadi, Maryam Bazzi, Kethineni Chandrika
pp. 339–343 · DOI: 10.5330/ijpi.2020.3.60 · Published
Objectives: Today, due to increasing usage of antibiotics and their destructive effects on health and environment, it is necessary to remove them from receiving waters. Although there are few studies on the use of magnet…
Article
Brain Targeted Delivery of Rizatriptan using Glutathione Conjugated Liposomes through Transmucosal Nasal Route
Rahul Ravindra Padalkar, Ashwini Raghavendra Madgulkar, Mangesh Ramesh Bhalekar
pp. 344–350 · DOI: 10.5330/ijpi.2020.3.61 · Published
Objectives: The objective of this work was to enhance the bioavailability of rizatriptan for brain targeted drug delivery through glutathione conjugated liposomes. Methods: Cholesterol glutathione conjugate was synthesiz…
Article
Diclofenac Sodium Stability in Simulated Gastrointestinal Fluids and the Use of MCM-41 Silica Carrier with Surface Modification to Achieve Innovative Delayed Release
Monica Chang Chuong, Pornpawit Suriyamongkol, Ria Vashishth, Ayushi Saxena, Charles Kelley
pp. 351–356 · DOI: 10.5330/ijpi.2020.3.62 · Published
Objectives: Porous silicon materials were first reported to be biocompatible in 1995. This project employed the evaluation of whether diclofenac sodium is acid labile or acid insoluble. Second, literature only reported 1…
Article
Biorelevant Dissolution Method Development for Dutasteride and Tamsulosin Hydrochloride Modified Release Capsule Simulating Post-prandial Condition
Devi Thamizhanban, Gampa Tulja Rani, Kathiresan Krishnasamy
pp. 357–363 · DOI: 10.5330/ijpi.2020.3.63 · Published
Objectives: This research work is aimed to develop bio relevant dissolution method by simulating human gastrointestinal condition at post-prandial state. The quality control dissolution procedure for modified release pro…
Article
Improving Bioavailability of Cefpodoxime Proxetil by Increasing Retention Time in Stomach with the Help of Natural Polymer: Formulation and Evaluation
Moizul Hasan, Syed Ayaz Ali, Furquan Nazimuddin Khan, Syed Iftequar Ahmed
pp. 368–373 · DOI: 10.5330/ijpi.2020.3.65 · Published
Background:Cefpodoxime proxetil is an orally administered, extended- spectrum, semi-synthetic antibiotic of the cephalosporin class. Cefpodoxime proxetil has a short elimination half-life and also possesses high solubili…
Article
Chromatographic Fingerprinting and Quantitative Analysis of Marker in the Extract of Gloriosa superba Tubers Collected from Some Region of Chhattisgarh
Rakesh Tirkey, Swarnlata Saraf
pp. 374–378 · DOI: 10.5330/ijpi.2020.3.66 · Published
Background:Gloriosa superba (Family: Liliaceae) is commonly known as Kalihari in India and has been used by several indigenous communities to treat a snake bite, skin diseases and joint pain. It has been also scientifica…
Article
Synergistic Interaction of Natural Snail Mucin and Lincomycin for Immuno-chemotherapy against Streptopneumococcal Infection: Checkerboard Evaluations
Thaddeus Harrison Gugu, Restus Chibuike Onwusoba, Patrick Ndubuisi Onyi, Angela Chizoba Ozioko
pp. 379–383 · DOI: 10.5330/ijpi.2020.3.67 · Published
Introduction: Pneumonia is an acute infection of lung majorly caused by Streptoneumococcal bacteria or other microbes which present cough with phlegm (mucus), fever and other clinical symptoms. This mucus produced are ea…
Article
Assessment of Immunostimulating effect of Carica papa- ya-based Immunostimulatory Complexes Against Streptococcus pneumoniae Infections
Tamunotonye Abel Briggs, Angus Nnamdi Oli, Ebere Innocent Okoye, AyokunnumiFunke Obajuluwa, ChineloKene Ezejiegu, Chijioke Maxwell Ofomata, Gordon C. Ibeanu
pp. 384–389 · DOI: 10.5330/ijpi.2020.3.68 · Published
Objectives: Streptococcus pneumoniae infection is a bacterial infection responsible for one-fifth of child mortality in Africa. The aim of this study was to formulate and evaluate Carica papaya-based Immunostimulatory co…
Article
Evaluation of Antiurolithiatic Potential of Piper cubeba Dried Fruits on Sodium Oxalate Induced Urolithiasis in Rats
Sura Suman, Solleti Venkata Suresh Kumar
pp. 390–395 · DOI: 10.5330/ijpi.2020.3.69 · Published
Objectives: The main endeavor of the work is to assess the antiurolithiatic potentials of ethanolic extract of Piper cubeba dried fruits (EEPC). Methods:EEPC was prepared using soxhlation, subjected to phytochemical scre…
Article
Antiepileptic and Antidepressant Activity of Majoon Najah (A Traditional Unani Formulation) in Experimental Animals
Mohd Urooj, Gulam Mohammed Husain, Mohd. Nadeem, Mohammed Abdul Rasheed Naikodi, Mahe Alam, Munawwar Husain Kazmi
pp. 396–401 · DOI: 10.5330/ijpi.2020.3.70 · Published
Background: Majoon Najah is a polyherbal traditional Unani formulation recommended for the treatment of neurological disorders. To evaluate antiepileptic and antidepressant activity of majoon najah and majoon najah extra…
Article
Sociodemographic Correlates of Practice towards Oral Hygiene among University Students: A Cross-sectional Insight
Muhammad Zahid Iqbal, Khaleda Omar, Abdul Nazer Ali, Mohd Baidi Bahari, Muhammad Shahid Iqbal
pp. 402–406 · DOI: 10.5330/ijpi.2020.3.71 · Published
Objectives: This study aimed to determine sociodemographic correlates of practice towards oral hygiene (OH) among university students in a private university. Methods: A cross-sectional study was performed among universi…
Article
Drug Utilization Pattern and Prescription Auditing of Antiepileptic Drugs and its Adverse Effects in Private Hospital
Pankaj Kumar Chaudhary, Maulin Mehta, Umesh Saroj
pp. 407–412 · DOI: 10.5330/ijpi.2020.3.72 · Published
Background: Epilepsy is a common medical condition characterized by repeated seizures due to a disorder of the brain cells. The data was limited regarding the prescribing pattern and side effects of various antiepileptic…
Article
Determinants Affecting Knowledge of Healthcare Students towards Mental Health Challenges
Muhammad Zahid Iqbal, Abdul Nazer Ali, Mohd Baidi Bahari, Muhammad Shahid Iqbal
pp. 413–416 · DOI: 10.5330/ijpi.2020.3.73 · Published
Objectives: The objective of the study was to evaluate the determinants affecting knowledge of healthcare students towards mental health challenges (MHCs) in a private medical university. Methods:A cross- sectional obser…