Volume 10, Issue 4

· pp. 417–611 · 33 articles

Volume: 10
Issue: 4
Published
Pages: 417–611
Articles: 33
Sections: 3
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article Short Communication

In this issue

Review Article

Review
A Review on Natural Sources of Antimalarials: Fungi and Plants
Tehzeeb T, Dhanabalan D
pp. 417–422 · DOI: 10.5330/ijpi.2020.4.74 · Published
Recent progress in drug discovery in past decades reduced the high level of pain experienced due to infectious diseases by humans. A significant impact has been made on developing novel antimicrobial agents but is failin…
Review
Clinical Utilization of Non-Anticoagulant - A Review
Pitchaimuthu Pandian
pp. 423–429 · DOI: 10.5330/ijpi.2020.4.75 · Published
Heparin is used as anticoagulant for long period and also other activities both experimentally and clinically. The heparin is prepared by many methods namely enzymatic hydrolysis, chemical hydrolysis by removing the anti…

Original Article

Article
Solubility Enhancement of BCS Classified II/IV Drug – Solid Dispersion of Apixaban by Solvent Evaporation
Amit Vinayak Asati, Kishor Sahebrao Salunkhe, Machindra Jairam Chavan, Ravindra Bhausaheb Chintamani, Rudra Pratap Singh
pp. 430–436 · DOI: 10.5330/ijpi.2020.4.76 · Published
Background: Solubility is an important physico-chemical factor affecting absorption of drug and its therapeutic effectiveness. One of the major problems responsible for the low turnout in the development of new molecular…
Article
Physiochemical and Structural Characterization of Biosurfactant Produced by Halophilic Pseudomonas aeruginosa ENO14 Isolated from Seawater
Ekramul Haque, Mohd Aamir Bin Riyaz, Sriram Shankar, Saqib Hassan
pp. 437–444 · DOI: 10.5330/ijpi.2020.4.77 · Published
Objectives: The aim of this study was to isolate a potent biosurfactant producing bacterium and characterize the produced biosurfactant for its application in pharmaceutical, petrochemical, cosmetic and food industry. Me…
Article
Preparation and Investigation of Gastro-Retentive Mucoadhesive Microspheres of Clarithromycin-Resin Complex
Johnson Stephin, Koland Marina
pp. 445–451 · DOI: 10.5330/ijpi.2020.4.78 · Published
Introduction: Helicobacter pylori infection is strongly associated with chronic gastritis and duodenal ulcers which can benefit from gastro retentive delivery of clarithromycin. Objectives: The objective of this study wa…
Article
Formulation, Development and Evaluation of Atorvastatin Ethosomal Gel
S Agarwal, G Gautam
pp. 452–455 · DOI: 10.5330/ijpi.2020.4.79 · Published
Background:The present investigation was held to develop vesicular ethosomal gel system for anti-hypertensive drug atorvastatin. Atorvastatin is a HMG-CoA reeducates inhibitor and utilized for minimizing cholesterol leve…
Article
Design, Formulation and Evaluation of Oxymel Containing Andrographis paniculata Extract
Prasad Suhas Kshirsagar, Darshana Sanjay Mote, Shriniwas Pramod Patil
pp. 456–459 · DOI: 10.5330/ijpi.2020.4.80 · Published
Introduction:Andrographis paniculata is medicinal plant of family Acanthaceae, consists of bitter principles and traditionally used in treatment of several gastrointestinal diseases. To mask its bitter taste, it could be…
Article
Formulation, Characterization and Evaluation of Behavioral Effects of Suspension and Effervescent Granules of Evolvulus alsinoides Linn. and Convolvulus pluricaulis Choisy
Garima Jain, Umesh K Patil
pp. 460–465 · DOI: 10.5330/ijpi.2020.4.81 · Published
Objectives:The objective of the present study was to formulate, characterize and evaluate herbal formulations of Evolvulus alsinoides and Convolvulus pluricaulis against scopolamine-induced behavioral disturbances for Al…
Article
Pharmaceutical Development of Nitrosourea Compound for the Treatment of Neuroendocrine Tumours
Zoya Shprakh
pp. 466–470 · DOI: 10.5330/ijpi.2020.4.82 · Published
Background: Nitrosoureas are chemotherapeutic alkylating agents, widely used in the treatment of malignant diseases. One of them (streptozotocin) is the standard for the therapy of neuroendocrine tumours. We synthesised …
Article
Formulation and Evaluation of Dolutegravir Proliposomal Powder for Pediatric HIV Patients
Naseeb Basha Shaik, Divya Shakelli, Lakshmi PK, Basava Rao VV
pp. 471–478 · DOI: 10.5330/ijpi.2020.4.83 · Published
Objectives: The objective of the present study was to improve the absorption of dolutegravir sodium by developing oral proliposomal formulation. Methods: Proliposomal formulations were prepared by film deposition on carr…
Article
Formulation Development and Characterization of Rapid Mouth Dissolving Film of Frovatriptan Succinate
Pankaj Bhatt, Suruchi Singh, Satish Kumar Sharma, Sani Rabiu
pp. 479–485 · DOI: 10.5330/ijpi.2020.4.84 · Published
Objectives:Aim of the present research work is to prepared rapid mouth dissolving film of frovatriptan Succinate. Methods: Rapid Dissolving Film is prepared by Solvent casting method, hydroxypropyl methylcellulose E3 and…
Article
Bioengineered Silver Nanoparticle from Spirulina platensis in Attenuating Biofilm Mediated Virulence in Vibrio parahemolyticus: An in vitro and in vivo Approach
Rathna Kumarasamy, Padavala Navyaka, Ekramul Haque
pp. 486–491 · DOI: 10.5330/ijpi.2020.4.85 · Published
Objectives:In this study, bioengineered AgNPs (silver nanoparticles) from Spirulina platensis was used to counter the biofilm mediated virulence by Vibrio parahemolyticus. Methods:AgNPs were synthesized from crude Spirul…
Article
α-(1→4)-linked D-galacturonic Acid Based Linear Homopolymer as Drug Release Modulator in HPMC Based Hydrodynamically Balanced System
Amit Verma, Neetu Sachan, Kamla Pathak, Anurag Verma
pp. 492–499 · DOI: 10.5330/ijpi.2020.4.86 · Published
Objectives: Natural polysaccharides are increasingly being used for diverse applications in drug delivery such as controlled release of drugs owing to their wide availability, renewability, biodegradability and biosafety…
Article
Preparation of Topical Nano Gel Loaded With Hesperidin Emulsomes: In vitro and in vivo Studies
Yeramanchi Sarah Sujitha, Yallamali Indira Muzib
pp. 500–505 · DOI: 10.5330/ijpi.2020.4.87 · Published
Objectives:The objective of the present study was to increase the solubility of poorly soluble drug hesperidin and to increase the efficacy of the drug by loading hesperidin in emulsomal topical gel. Methods: Hesperidin …
Article
Self Nano-emulsifying Drug Delivery System to Enhance Solubility and Dissolution of Candesartan Cilexetil
Pathuri Raghuveer, Avula Prameela Rani
pp. 506–511 · DOI: 10.5330/ijpi.2020.4.88 · Published
Aim: Self nano-emulsifying drug delivery system (SNEDDS) of candesartan cilexetil was explored to enhance its oral bioavailability. SNEDDS has tremendous potential in enhancing oral bioavailability of poorly aqueous solu…
Article
Quality by Design based Development and Validation of RP-HPLC Method for Simultaneous Estimation of Sitagliptin and Metformin in Bulk and Pharmaceutical Dosage Forms
Balamurugan Krishnan, Kirtimaya Mishra
pp. 512–518 · DOI: 10.5330/ijpi.2020.4.89 · Published
Objectives: This paper portrays a recently developed, optimized and validated isocratic RP-HPLC strategy for the separation of two anti- diabetic drugs (sitagliptin and metformin) in bulk and pharmaceutical formulations …
Article
Altitude Variation in Volatile Composition of Blueberry Leaf Analyzed by SPME GC-MS
İshak Erik, Gözde Kılıç, Sevde Seher Yaylı, Gülşah Yılmaz, Kamil Coşkunçelebi, Nurettin Yaylı
pp. 519–525 · DOI: · Published
Background:The present work was aimed to carry out volatile component analyzes in Vaccinium arctostaphlyos L., V. uliginosum L., V. vitis-idaea L. and V. myrtillus L leaf growing at different altitudes of the East Blacks…
Article
Stability Indicating LC-MS Method Development and Validation for the Study of the Forced Degradation Behavior of Pimobendan Drug
Atchuta Ramakrishna Gudapati, Srinivasarao Pakalapati, Chidananda Swamy Rumalla, Benarji Patrudu Tammina
pp. 526–530 · DOI: 10.5330/ijpi.2020.4.91 · Published
Objectives: Analytical methods are necessary for the field of pharmaceuticals to discover the drug, determination of drugs and metabolites in biological matrices. The present study aimed to develop liquid chromatography-…
Article
Novel Development of RP-HPLC Method to Quantify Amoxicillin, Omeprazole and Rifabutin in Combination
Rama Kumar Kandula, Raja Sundararajan
pp. 531–536 · DOI: 10.5330/ijpi.2020.4.92 · Published
Objectives: Helicobacter pylori infections are liable for most of the ulcers in the stomach and small intestinal. Talicia capsules was approved to be prescribed for the Helicobacter pylori infections. These capsules have…
Article
A Novel Ultra Performance Liquid Chromatography-PDA Method Development and Validation for Alectinib in Bulk and its Application to Tablet Dosage Form
HK Sundeep Kumar, Sujit Kumar Sahu, Jitendra Debata
pp. 537–541 · DOI: 10.5330/ijpi.2020.4.93 · Published
Objectives: To develop a novel ultra-performance liquid chromatographic technique for the estimation of alectinib in a API and tablet. Methods: The chromatographic separation was achieved using DIKMA Endoversil (2.1 x 50…
Article
Apoptosis Induction and Anticancer Activity of 2, 4-bis (1-phenylethyl) Phenol from Clerodendrum thomsoniae Balf.f. in vitro
VK Muhammed Ashraf, VK Kalaichelvan, R Ragunathan, V V Venkatachalam
pp. 542–547 · DOI: 10.5330/ijpi.2020.4.94 · Published
Objectives: Plant phenolic have extended significance as a promising therapeutic candidate for several disorders including cancer. Apoptosis is a well-organized cell death that has importance in cancer research. The pres…
Article
Effect of Deoxycholic Acid on Immune Cells - An Immunophenotyping Analysis of Peripheral Blood and Splenic Lymphocytes in CD57 Female Mice
Praveen Kumar Reddy Moole, Jagan Mohan Reddy Papireddypalli
pp. 548–552 · DOI: 10.5330/ijpi.2020.4.95 · Published
Background: Deoxycholic acid has been used in Chinese traditional medicine “Niuhuang” that is known to have Immunoregulatory and anti-inflammatory properties. Preliminary evidences have shown that Deoxycholic acid modula…
Article
In vitro Investigation of Conventional, Chitosan Coated and Electrosteric Stealth Liposomes of Rivastigmine Tartrate for the treatment of Alzheimer’s Disease
Srinivas Hebbar, Manasa Poonja, Amitha Shetty, Akhilesh Dubey
pp. 553–558 · DOI: 10.5330/ijpi.2020.4.96 · Published
Objectives:The main objective of the present investigation was to develop and compared conventional, chitosan-coated and electrosteric stealth liposomes of Rivastigmine Tartrate for the treatment of Alzheimer’s Disease. …
Article
Antibacterial Activity of Extracts of Solanum xanthocarpum, Aegle marmelos and Capparis spinose Against Antibiotic- resistant Staphylococcus cohnii
Palanisamy Natarajan, Anbalagan Sorimuthu, Sankareswaran Muruganantham, Moorthy Marimuthu
pp. 559–563 · DOI: 10.5330/ijpi.2020.4.97 · Published
Background: The antibacterial activity of plant extracts and phytochemicals analysis was evaluated with antibiotic susceptible and resistant micro-organisms. In addition, of the possible coefficient effects when associat…
Article
Screening of Antimicrobial and Antioxidant Activity of Acetone Extracts of Heritiera fomes Whole Plant against Pathogens
Chepuri Kalyani, Chidepudi Devi Sri Lalitha Naga Tulasi, Swathi Minumula Sudarshan, Adelli Geetha, Mangamoori Lakshmi Narasu, Lavudi Saida
pp. 564–568 · DOI: 10.5330/ijpi.2020.4.98 · Published
Background: Phytochemicals are well known to have many important pharmaceutical properties. Heritiera fomes grows in low saline environments. The present study was initiated to explore the biologically beneficial propert…
Article
Antiparkinsonian and Antioxidant Effects of Hydroalcoholic Extract of Camellia sinensis, Asparagus racemosus, Mucuna pruriens and their Combination
Mahendra Ashok Giri, Rasika Dnyandeo Bhalke, K Vanitha Prakash, Sanjay Bhaskar Kasture
pp. 569–574 · DOI: 10.5330/ijpi.2020.4.99 · Published
Objectives: Because of environmental risk factors Parkinson’s disease rate doubled in last decades. In upcoming decades rate of Parkinson’s disease is expected to be 12 million people in aging population. Present treatme…
Article
Pyocyanin Assisting Biosurfactant Mediated Anti-shrimp Pathogen Activity and Crude Oil Recovery
Sriram Shankar, Ekramul Haque, Saqib Hassan
pp. 575–580 · DOI: 10.5330/ijpi.2020.4.100 · Published
Background:The unflagging engrossing biosurfactant, representing ecological substitute to their synthetic equivalent has gained enormous attention in the 21st century and their potential applicability in food, medicine a…
Article
Randomized Control Trial to Assess the Efficacy and Safety of NRL/2019/5PNW with Micronutrient Fortification to Promote Health and Well-being in Woman in Fertile Age
Priya Khare, Omkar Kulkarni, Anuj Agrawal, Gayatri Ganu, Medha Joshi, Manjit Sisode
pp. 581–585 · DOI: 10.5330/ijpi.2020.4.101 · Published
Background:Women appear with gender specific nutritional requirements that may affect their well-being. The nutritional requirements are there for women in rural, suburban and urban regions altogether. Objective: Netsurf…
Article
A Double-blind, Placebo-controlled, Randomized Comparison of Analgesic Efficacy of Oral Ketorolac Versus Intramuscular Tramadol After Third Molar Surgery
Fazil Arshad Nasyam
pp. 586–589 · DOI: 10.5330/ijpi.2020.4.102 · Published
Background:Pain due to dental extraction, particularly after the third molar extraction causes discomfort to patients. Different types of analgesics used to manage pain in such cases include nonsteroidal anti-inflammator…
Article
Efficacy of Sitagliptin Versus Glimepiride 1-3 mg for Treatment of Type-2 Diabetes Patients
Bhaskar Joshi, Praveen Yadav, Annabathini Geetha Bhavani
pp. 590–593 · DOI: 10.5330/ijpi.2020.4.103 · Published
Objectives:This study is to compare the effect of Sitagliptin and Glimepiride 1-3mg as a combination therapy for type-2 diabetes mellitus patient’s treatment. It is also concern to evaluate the effect of low dosage on ty…
Article
Synthesis, Docking and Anti-cancerous Activity of Some Novel Thiazole Derivatives of Biological Interest
Anitha Ramalingam, Sarvanan J
pp. 594–603 · DOI: 10.5330/ijpi.2020.4.104 · Published
Objectives: Heterocyclic compounds are enormously widespread in nature and have attracted research interest because of their pharmaceutical and biological properties. Amongst the heterocyclic rings, the thiazoles are the…
Article
Correlates of Attitude Towards Amyotrophic Lateral Sclerosis among Health Care Students - A Cross-sectional Study Findings
Muhammad Zahid Iqbal, Salah-Ud-Din Khan, Muhammad Shahid Iqbal
pp. 604–607 · DOI: 10.5330/ijpi.2020.4.105 · Published
Objectives:To evaluate correlated factors (correlates) of attitude towards Amyotrophic Lateral Sclerosis (ALS) among health care students in a medical university. Methods:A stratified convenient sampling technique was us…

Short Communication

Communication
Study of Polymorphism on Pargeverine Hydrochloride
Gopal Krishna Rao, Nutan Naik
pp. 608–611 · DOI: 10.5330/ijpi.2020.4.106 · Published
Objectives: Screening active pharmaceutical ingredients for polymorphs is of utmost importance in drug development to enable stable APIs, robust manufacturing processes and reduction of costs incurred in switching over c…