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Article

Antiepileptic and Antidepressant Activity of Majoon Najah (A Traditional Unani Formulation) in Experimental Animals

Mohd Urooj1★, Gulam Mohammed Husain1, Mohd. Nadeem1, Mohammed Abdul Rasheed Naikodi2, Mahe Alam3, Munawwar Husain Kazmi1★ Corresponding author

  1. 1Pharmacology Research Laboratory, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, Telangana, INDIA.
  2. 2Drug Standardization Research Unit, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, Telangana,, INDIA.
  3. 3Central Council for Research in Unani Medicine, New Delhi, INDIA.

CORRESPONDENCE

Mohd Urooj

Pharmacology Research Laboratory, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, Telangana, INDIA.

qaziurooj@gmail.com

Received: 26-06-2020; Revised: 14-07-2020; Accepted: 16-08-2020.

Volume 10, Issue 3 · pp. 396–401 · PUBLISHED · DOI: 10.5330/ijpi.2020.3.70

View on IJPI original site ↗

ABSTRACT

Background: Majoon Najah is a polyherbal traditional Unani formulation recommended for the treatment of neurological disorders. To evaluate antiepileptic and antidepressant activity of majoon najah and majoon najah extract in experimental animals. Methods: Anticonvulsant activity was tested using maximal electroshock induced convulsion in male sprague dawley rats using diazepam 3 mg/kg, p.o. as positive control. Pentylenetetrazole induced convulsion in swiss male albino mice was performed using phenytoin 25 mg/kg i.p. as positive control. The antidepressant activity of MN was evaluated using forced swim test model in male using Imipramine 20 mg/kg, p.o. as positive control. Results: Antiepileptic study data showed reduction of all parameters like, tonic hind limb extension, clonic convulsion and stupor; however the values were not found statistically significant at all tested dose levels. The results of forced swim test model indicated that majoon najah effectively showed significant (P<0.001) reduction in immobility duration in animals treated with majoon najah classical at dose 500 mg/kg bw and 1000 mg/kg bw as compared to control rats. Conclusion: Based on above findings, it may be concluded that majoon najah did not showed effectiveness in epilepsy however, the results evident that majoon najah is a potential Unani formulation having antidepressant activity which may be preferred as an alternative therapy over modern medicine to treat depression.

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    Urooj, M., Husain, G. M., Nadeem, M., Naikodi, M. A. R., Alam, M., & Kazmi, M. H. (). Antiepileptic and Antidepressant Activity of Majoon Najah (A Traditional Unani Formulation) in Experimental Animals. International Journal of Pharmaceutical Investigation, 10(3), 396–401. https://doi.org/10.5330/ijpi.2020.3.70