Assessment of Anti-inflammatory and Anti-Proliferative Potential of Euphorbia hirta Roots: An in vitro Analysis

ABSTRACT

Background: The current study focuses in vitro anti-inflammatory and anti-proliferative evaluation of the alcoholic extract of euphorbia hirta roots. Anti-inflammatory potential was screened by incorporating inhibition of protein denaturation assay and anti-proliferative potential by MTT assay. Methods: Anti-inflammatory potential of extract was evaluated by calculating the percentage inhibition of protein denaturation and anticancer activity of the alcoholic extract was assessed by evaluating the cell viability. Alcoholic roots extract of euphorbia hirta was treated with MCF – 7 cell lines and cell viability was determined at the wavelength of 570 nm by MTT method. Results:The results suggested the significant anti-inflammatory potential as it effectively inhibits the protein denaturation. The alcoholic roots extract of euphorbia hirta also showed anti-proliferative effect against MCF - 7 celllines (p ≤0.05) in a dose dependent manner. Conclusion:The root extract showed potential anti-inflammatory and anti-proliferative potential. As from the results, it was concluded that extract had capability to constrain the propagation of cancer cells. Therefore, it appears to be a virtuous contender to provide protection against growth of tumour cells.

KEYWORDS

• Euphorbiaceae
• Medicinal plants
• Phytoconstituents
• Anticancer
• Protein denaturation

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• DOI10.5530/ijpi.2021.4.79Copy