Volume 11, Issue 4

· pp. 345–443 · 18 articles

Volume: 11
Issue: 4
Published
Pages: 345–443
Articles: 18
Sections: 3
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article Short Communication

In this issue

Review Article

Review
P-glycoprotein Expression in Solid Tumors – An Analysis
Kakuli Chakraborty, Pratiti Ghosh
pp. 345–348 · DOI: 10.5530/ijpi.2021.4.61 · Published
P-glycoprotein is an efflux transporter belonging to the ATP Binding Cassette (ABC) family of transporters and is encoded by Multidrug resistance (MDR1) gene. It is primarily involved in efflux of xenobiotics that permea…
Review
Overview of Post Approval Changes Requirements for Active Pharmaceutical Ingredients in Canada, Australia and Saudi Arabia
Mausami Vaghela, Pankaj Kapupara
pp. 349–353 · DOI: 10.5530/ijpi.2021.4.62 · Published
Regardless of a product’s country of registration, a current and updated pharmaceutical product dossier is mandatory. But any kind of post-approval change to pharmaceutical products requires prior permission or at least …

Original Article

Article
Anticancer Activity of Elytraria acaulis L. Extracts on Triple Negative Breast Cancer Cell Line
Suresh Babu Bastipati, Chepuri Kalyani, Chidepudi Devi Sri Lalitha Naga Tulasi, Lavudi Saida
pp. 354–357 · DOI: 10.5530/ijpi.2021.4.63 · Published
Objectives: In the present study, the anticancer potential of the plant extracts of Elytraria acaulis L. (E. acaulis L.) were investigated on human breast cancer cells (MDAMB-231). Methods: Different organic solvent extr…
Article
Anti-inflammatory Activity of Chlorella vulgaris in Experimental models of Rats
Swapnil Prakash Chaudhari, Dheeraj Tukaram Baviskar
pp. 358–361 · DOI: 10.5530/ijpi.2021.4.64 · Published
Background:The aim of present study is to evaluate the anti-inflmmatory activity of Chlorella vulgaris in acute and chronic experimental inflammatory model. Plant extract was analyzed for photochemical screening of diffe…
Article
Standardization of Kirāmpu kutinīr Decoction and Extract Granules using Pharmacognostic, Physicochemical and HPTLC Studies
Brindha Sundaramoorthy, Achintya Kumar Mandal, Vinayak Soman, Shree Devi Munusamy Sampangiramulu, Sunil Kumar Koppala Narayana, Shakila Ramachandran, Sathiyarajeswaran Parameswaran, Kiruthiga Ganesan
pp. 362–367 · DOI: 10.5530/ijpi.2021.4.65 · Published
Introduction:Siddha being one of the ancient systems of medicine, has been counted on by most of the population during the outbreak of pandemics in recent times. The decoctions like nilavempu kutinir and kapacura kutinir…
Article
Scientific Appraisal of Classical Calcination Process of Kushta (Calx) in Reference to Calx of Copper Sulphate
Sumera Mehfooz, Abdul Wadud, Hamiduddin H, Rajeev Ranjan
pp. 368–373 · DOI: 10.5530/ijpi.2021.4.66 · Published
Background:Kushta, a dosage form of Unani medicine is prepared by employing well-designed procedures. The correct procedure ensures the production of Kamil (perfect) Kushta considered as safe, while a deviation from the …
Article
Synthesis, Characterization, and Evaluation of in vitro Antidiabetic Activity of Novel Pyrrolidine Sulphonamide Derivative
Megha Tukaram Salve, Shailaja Bhanudas Jadhav
pp. 374–378 · DOI: 10.5530/ijpi.2021.4.67 · Published
Background: Diabetes is a long-term illness characterized by high blood sugar levels. It is estimated that by 2045, there will be nearly 693 million diabetic patients worldwide, with half of the population remaining undi…
Article
Characterization of Ephedrine as Illegal Methamphetamine Precursors Based on δ15N, δ13C, and δ2 H Isotopes: Their Application for Methamphetamine Profiling in Indonesia
Puteri Heryani Supriatna, Harmita Harmita, Yahdiana Harahap
pp. 379–383 · DOI: 10.5530/ijpi.2021.4.68 · Published
Objectives: The δ15N, δ13C, and δ2 H profile of the ephedrine as a methamphetamine precursor is a fingerprint to describing its origin. The origin of the precursor is one of the supporting data in methamphetamine profili…
Article
Highly Efficient Adsorption and Removal of Amoxicillin from Aqueous Solution by Magnetic Graphene Oxide Nanocomposite
Ferdos Kord Mostafapour, Maryam Bazi, Shaziya Haseeb Siddiqui, Hossein Bagheri, Davoud Balarak
pp. 384–388 · DOI: 10.5530/ijpi.2021.4.69 · Published
Background:Antibiotics have lasting effects on the environment. Among the properties of these substances are non-biodegradable, carcinogenic, high toxicity, and an increase in antibiotic-resistant bacteria. Therefore, th…
Article
Electrochemical Recognition and Electrochemical Oxidation of Mesalazine Drug at PMA Modified Glassy Carbon Electrode
B Sreenatha Gupta, Madhusudhan Rao Vallabhaneni
pp. 389–394 · DOI: 10.5530/ijpi.2021.4.70 · Published
Background:Electrochemistry was the foremost subdivision of the chemistry its interred correlated to the entire other chemistries. Primarily it can settle on the nature of compound reactions by physically depends on the …
Article
Method Development Combined with in silico Therapeutic and Toxicology Studies on Palbociclib and its Degradation Products to Assist in Discovery of New Molecule
Shaik Reehana, Kamepalli Sujana
pp. 395–402 · DOI: 10.5530/ijpi.2021.4.71 · Published
Background:Palbociclib is anti-cancer drug which interacts with cyclindependent kinase. There are no methods repoRTed for the characterization of palbociclib together with degradation products (DPs). The main aim of the …
Article
Formulation, Optimization, and in vitro Characterization of Curcumin Loaded Liposomes for Colonic Delivery
Ankita Tiwari, Sanjay K Jain
pp. 408–413 · DOI: 10.5530/ijpi.2021.4.73 · Published
Background:Curcumin has been extensively employed in the treatment of several diseases in traditional medicine, including cancer.The main obstacles that avert its approval as a therapeutic moiety are its low aqueous solu…
Article
Formulation, Optimization and Evaluation of Non-aerosol Topical Spray of Lidocaine for Pain Management
Neelam Pawar, Anoop Parmar, Kavita Bahmani, DN Mishra, Renu Malik, Neha Minocha, Pawan Jalwal, Rahul Pawar
pp. 414–419 · DOI: 10.5530/ijpi.2021.4.74 · Published
Background:The optimization study was conducted in an attempt to develop a non-pressurized topical spray of Lidocaine without propellant. Methods:Central composite design was selected to determine the best conditions for…
Article
Orodispersible Films of Meloxicam Inclusion Complexes for Bioavailability Enhancement: Optimization and Development through Quality by Design Approach
Archana Nerella, MV Nagabhushanam
pp. 420–425 · DOI: 10.5530/ijpi.2021.4.75 · Published
Background: Owing to overcome the dissolution limited bioavailability of Meloxicam, the current research involves the development of Orodispersible films using Meloxicam by employing Quality by Design. Methods:In this wo…
Article
Evaluation of Medication Adherence and Associated Factors in Hypertensive Patients in Bangalore, India; A Cross-Sectional Study
Amar Prashad Chaudhary, Jeswin George, Kaveri Kadowade, Lubna Faiyza, Rabiya Anjum, Uma V M, Sharath K N
pp. 426–431 · DOI: 10.5530/ijpi.2021.4.76 · Published
Background: This survey aims to determine medication compliance among hypertension patients and discover factors influencing medication compliance. Methods:This study incorporated a cross-sectional study design. The Hill…
Article
Prescription Pattern in the Management of Secondary Prevention of Stroke in Post Stroke Patients
Jisha Annie, RC Doijad, Emmanuel James
pp. 432–436 · DOI: 10.5530/ijpi.2021.4.77 · Published
Background:To analyze the drug prescription pattern for secondary prevention of stroke, medication adherence, knowledge and awareness about the disease, direct medical cost involved in the treatment of stroke. Methods:A …
Article
Formulation and Evaluation of Clay Face Pack
Swati Siddheshwar Londhe, Amol Arun Joshi, Geeta Narsingrao Sapkale, Mangesh Gautam Bhosale
pp. 437–440 · DOI: 10.5530/ijpi.2021.4.78 · Published
Background:The skin is a very sensitive protective layer for the human body and is exposed to environmental pollution, so it is very important to protect the skin. Facial skin can be protected by using various cosmetics …

Short Communication

Communication
Assessment of Anti-inflammatory and Anti-Proliferative Potential of Euphorbia hirta Roots: An in vitro Analysis
Rashmi Wadhwa, Pankaj Gupta
pp. 441–443 · DOI: 10.5530/ijpi.2021.4.79 · Published
Background: The current study focuses in vitro anti-inflammatory and anti-proliferative evaluation of the alcoholic extract of euphorbia hirta roots. Anti-inflammatory potential was screened by incorporating inhibition o…