Anticancer Activity of Elytraria acaulis L. Extracts on Triple Negative Breast Cancer Cell Line
Suresh Babu Bastipati1, Chepuri Kalyani1, Chidepudi Devi Sri Lalitha Naga Tulasi1, Lavudi Saida1★★ Corresponding author
- 1Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, INDIA.
CORRESPONDENCE
Lavudi Saida
Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, INDIA.
Received: 03-07-2021; Revised: 11-08-2021; Accepted: 17-09-2021.
Volume 11, Issue 4 · pp. 354–357 · PUBLISHED · DOI: 10.5530/ijpi.2021.4.63
ABSTRACT
Objectives: In the present study, the anticancer potential of the plant extracts of Elytraria acaulis L. (E. acaulis L.) were investigated on human breast cancer cells (MDAMB-231). Methods: Different organic solvent extracts of E. acaulis L. were prepared using methanol, ethanol, ethyl acetate and hexane. The cytotoxicity of plant extracts were evaluated by MTT assay (-(4, 5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) against MDA MB-231cells. The apoptosis associated morphological changes were also observed with the help of propidium iodide staining method. Results: Of all the solvent extracts, methanol extract has shown the highest activity and its IC50 concentration was found to be 80.8±2.08 μg/ml. The anticancer drug Cis-diammineplatinum (II) dichloride was considered as a standard. Conclusion:In further the bioactive compound should be isolated from the methanol crude extract, which is responsible for the cytotoxic effects.
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Bastipati, S. B., Kalyani, C., Tulasi, C. D. S. L. N., & Saida, L. (). Anticancer Activity of Elytraria acaulis L. Extracts on Triple Negative Breast Cancer Cell Line. International Journal of Pharmaceutical Investigation, 11(4), 354–357. https://doi.org/10.5530/ijpi.2021.4.63