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International Journal of Pharmaceutical InvestigationNOW IN
Article

Phytochemical and Molecular Docking Studies on Indigenous Herbs Glycyrrhiza glabra, Terminalia chebula and Hamdard joshanda

T. H. Mohamed Ahadu Shareef1★, Mohamed Divan Masood2★ Corresponding author

  1. 1Department of Chemistry, The New College (Autonomous)-Affiliated to the University of Madras, Chennai, Tamil Nadu, INDIA.
  2. 2School of Computer Applications, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, INDIA.

CORRESPONDENCE

T. H. Mohamed Ahadu Shareef

Department of Chemistry, The New College (Autonomous)-Affiliated to the University of Madras, Chennai, Tamil Nadu, INDIA.

jasshaali@gmail.com

Received: 23-12-2021; Revised: 21-01-2022; Accepted: 12-02-2022.

Volume 12, Issue 1 · pp. 7–14 · PUBLISHED · DOI: 10.5530/ijpi.2022.1.2

View on IJPI original site ↗

ABSTRACT

Background:Glycyrrhiza glabra,Terminalia chebulaandHamdard joshandais used as a traditional home medicine in developing countries that is easily available for a lesser cost with no side effects. These medicine decoctions made record in pandemic that have found efficacious in Covid-19 patients with RTI in addition to Dengue and Malarial fever. Our study aimed to explore the qualitative as well as quantitative in potential traditional medicines such asGlycyrrhiza glabra,Terminalia chebulaandHamdard joshandathrough phytochemical and GC-MS analytical technique were conducted for finding all the potential chemical constituents in these herbal medicines. Docking studies were carried out betweenGlycyrrhiza glabra,Terminalia chebulaandHamdard joshandaand receptors of the crystal structure of SARS coronavirus, Lung Cancer andMycobacterium tuberculosisproteins. Materials and Methods: The presence of various phytochemicals, total phenolic and flavonoid content were determined in Glycyrrhiza glabra, Terminalia chebula and Hamdard joshanda by standard procedure. Docking study was investigated using the crystal structure of SARS coronavirus protease for the modeling (PDB ID: 3SN8), Lung Cancer Protein for the modeling (PDB ID: 6JZ0) andMycobacterium tuberculosisprotein for the modeling (PDB ID: 4FDO). Results: GC-MS chromatogram showed 26, 18 and 23 peaks that revealed 26, 18 and 23 phytoconstituents present inGlycyrrhiza glabra,Terminalia chebula, andHamdard joshandarespectively. Total phenolic and flavonoid contents found inGlycyrrhiza glabra,Terminalia chebula, andHamdard joshandawere 1.95, 1.88, 1.55, and 0.66, 0.56, 0.49 mg/ml, respectively. Docking studies were exhibited that moderate to higher efficacy against Covid-19, Tuberculosis and Lung cancer. However, several more in vivo and in vitro research needs to investigate their molecular system or any other significance of unused bioactive substance in these traditional medicines used for human relapse. Conclusion: These potential traditional medicines have been confirmed to be safe for human consumption and the present study would also suggest its direct consumption as well as for attaining the proven benefits.

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    Shareef, T. H. M. A., & Masood, M. D. (). Phytochemical and Molecular Docking Studies on Indigenous Herbs Glycyrrhiza glabra, Terminalia chebula and Hamdard joshanda. International Journal of Pharmaceutical Investigation, 12(1), 7–14. https://doi.org/10.5530/ijpi.2022.1.2