A Novel Approach of Leflunomide Nanoemulgel for Topical Drug Delivery System
Vivek Verma1★, T S Easwari1★ Corresponding author
- 1Department of Pharmaceutics, IIMT College of Medical Sciences, IIMT University, Meerut, Uttar Pradesh, INDIA.
CORRESPONDENCE
Vivek Verma
Department of Pharmaceutics, IIMT College of Medical Sciences, IIMT University, Meerut, Uttar Pradesh, INDIA.
Received: 31-03-2022; Revised: 16-04-2022; Accepted: 01-05-2022.
Volume 12, Issue 2 · pp. 199–204 · PUBLISHED · DOI: 10.5530/ijpi.2022.2.35
ABSTRACT
Objectives: This research’s primary goals are Leflunomide (LFD) nanoemulgel formulation and characterization for topical administration. Materials and Methods:A pseudo ternary phase diagram was created utilizing castor oil, Tween 20 as the surfactant, PEG 300 as a co-surfactant, and ethanol as the cosolvent. Spontaneous emulsification was used to create LFD-nanoemulgel, which is now commercially available. Gel matrix Carbopol 934 was employed to generate nanoemulgel in the prepared nanoemulsion. Studies on the LFD-globule nanoemulgel’s size, physical appearance, viscosity, spreadability, TEM, FTIR drug content, release kinetics, and stability contributed to its characterization and assessment. Optimum nanoemulgel formulation contained 6% castor oil, 36% Tween 80 and PEG 300 as Smix (surfactant and co-surfactant mixture), 46% water, and 12% w/w carbopol 934.Results: The produced nanoemulgel was translucent and had a zeta potential of 26.12 mV and a particle size of 113.55 ± 1.73 nm. The improved formulation has a drug release rate of 98.13% ± 1.20%. They were determined to be ideal for pH, viscosity, and spreadability. According to the stability analysis, the generated nanoemulgel was shown to be stable at temperatures ranging from 25 ± 45°C, according to the stability analysis results. Conclusion: An effective formulation for topical medication delivery using LFD-loaded nanoemulgel has been developed. It may be an alternative drug therapy to the topical application of drugs to treat arthritis.
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Verma, V., & Easwari, T. S. (). A Novel Approach of Leflunomide Nanoemulgel for Topical Drug Delivery System. International Journal of Pharmaceutical Investigation, 12(2), 199–204. https://doi.org/10.5530/ijpi.2022.2.35