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International Journal of Pharmaceutical InvestigationNOW IN
Article

Development and Validation of Prochlorperazine Maleate in Bulk and Pharmaceutical Dosage Form by UV Spectroscopic Method

Hina Bagada1★, Vishva Bhut1, Himaxi Parmar1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, A.R. College of Pharmacy and G. H Patel Institute of Pharmacy Vallabh Vidyanagar, Anand, Gujarat, INDIA.

CORRESPONDENCE

Hina Bagada

Department of Pharmaceutical Chemistry, A.R. College of Pharmacy and G. H Patel Institute of Pharmacy Vallabh Vidyanagar, Anand, Gujarat, INDIA.

bagadahina@gmail.com

Received: 06-05-2022; Revised: 22-05-2022; Accepted: 06-06-2022.

Volume 12, Issue 3 · pp. 288–292 · PUBLISHED · DOI: 10.5530/ijpi.2022.3.50

View on IJPI original site ↗

ABSTRACT

Background:Prochlorperazine maleate is an antipsychotic and antiemetic drug that is available as tablets on the market for oral administration. The main object of this research work is to develop and validate the easiest UV spectroscopic method for the determination of Prochlorperazine maleate for tablet formulation (marketed formulation). Materials and Methods:A simple, reproducible and efficient method for the determination of Prochlorperazine maleate in bulk and tablet formulations have been developed. The developed method is based on the estimation by UVVisible spectroscopy. In this method, 0.3M HCL was selected as the solvent. A Wavelength selected for estimation of Prochlorperazine maleate was 254 nm. Results: Linearity was found in the concentration range 2-16μg/ml (R2=0.9909). A recovery study was found to be 98.01-99.79% for Prochlorperazine maleate. The method was found to be precise as % RSD was low in repeatability, intermediate precision, and reproducibility. LOD and LOQ were found to be 0.58 and 1.75 respectively. Conclusion:The method was found to be very simple, and precise. It also had a good recovery. The Developed method can be used for further routine analysis and stability study of a Prochlorperazine maleate.

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    Bagada, H., Bhut, V., & Parmar, H. (). Development and Validation of Prochlorperazine Maleate in Bulk and Pharmaceutical Dosage Form by UV Spectroscopic Method. International Journal of Pharmaceutical Investigation, 12(3), 288–292. https://doi.org/10.5530/ijpi.2022.3.50