International Journal of Pharmaceutical Investigation
Volume 12, Issue 3
· pp. 250–398 · 23 articles
- Volume
- 12
- Issue
- 3
- Published
- Pages
- 250–398
- Articles
- 23
- Sections
- 4
- ISSN
- Print - 2230-973X, Online -2230-9713
- Journal
- IJPI
In this issue
Review Article
- Review
Threatened Ayurvedic Herb (Seeta Ashoka) Substitution Options for Menorrhagia-based on Bioactive Principle’s Molecular Docking Study
Utkarsh Ghate, Hema Kulkarni, Manasi Deshpande, Mandar Akkalkotkar
pp. 250–254 · DOI: 10.5530/ijpi.2022.3.45 · Published
Molecular docking studies are used to identify cultivated/ abundant herbs such as Coriander, Burmuda grass or Asparagus as potential replacement for Seeta Ashoka- Saraca asoca (Roxb.) De Wilde, syn. S. indica Linn. a rar…
Original Article
- Article
Phytochemical Profiling and Antioxidant Potential of Coconut Inflorescence Sap
Raseema Raheema Sharafudeen, Annie Abraham, Reshma Usha Soman
pp. 255–259 · DOI: 10.5530/ijpi.2022.3.46 · Published
Background: The coconut palm is so much more than just a tree; because all of this is essential with medicinal benefits. Coconut inflorescence sap (CIS) is the sweet, oyster-white colored, non-fermented juice tapped from…
- Article
Virtual Screening of Potential Quorum Sensing Inhibitors of P. aeruginosa
Snigdha Bhardwaj, Pushpraj S Gupta
pp. 260–271 · DOI: 10.5530/ijpi.2022.3.47 · Published
Background: Pseudomonas aeruginosa (P. aeruginosa) is considered as one of the most opportunistic pathogens that may infect humans and led to increase in bacterial virulence or pathogenicity. P. aeruginosa exhibits varie…
- Article
Synthesis, Characterization and Release Studies of Ethylene Diamine Tetraacetic Acid (EDTA)-Antimicrobial Drug Conjugates for Colon Release
Anoop Kumar, Ashutosh Mishra
pp. 272–279 · DOI: 10.5530/ijpi.2022.3.48 · Published
Background:The colon targeted drug delivery system is mainly useful for the topical treatment of colon diseases such as ulcerative colitis, Crohn’s disease OR colorectal cancers where we attain high local concentration a…
- Article
Targeting Amide Herbicides by KARI of Staphylococcus aureus- an in silico Analysis
Rajasekhar Pinnamaneni, Udaya Sri Puttagunta
pp. 280–287 · DOI: 10.5530/ijpi.2022.3.49 · Published
Background: Herbicides are classified either by toxicity or by mechanism of action, based on the chemical nature of the compound. Herbicides fall into two categories. Contact the herbicide and the transferred herbicide. …
- Article
Development and Validation of Prochlorperazine Maleate in Bulk and Pharmaceutical Dosage Form by UV Spectroscopic Method
Hina Bagada, Vishva Bhut, Himaxi Parmar
pp. 288–292 · DOI: 10.5530/ijpi.2022.3.50 · Published
Background:Prochlorperazine maleate is an antipsychotic and antiemetic drug that is available as tablets on the market for oral administration. The main object of this research work is to develop and validate the easiest…
- Article
Development and Characterization of Silymarin Phospholipid Complex for Improved Solubility, and Toxicological Evaluation in Experimental Animals
Mandeep Kumar Singh, Umesh Kumar Patil
pp. 299–316 · DOI: 10.5530/ijpi.2022.3.52 · Published
Objectives: The silymarin phytosome (SPY) was developed to improve the solubility and dissolution. The prepared phytosome was evaluated for hemolytic, membrane stabilization activity, and in vivo acute and subchronic tox…
- Article
Formulation and Evaluation of Eudragit L- 100 based Nanoparticles of Senna for Treatment of Constipation
Ashish Yashwantrao Pawar, Ashvini Dhanraj Tapkir, Jyoti Bramhesh Rao, Rushikesh Pramod Dayama
pp. 317–322 · DOI: 10.5530/ijpi.2022.3.53 · Published
Background:The pharmaceutical industries are keen in development of new herbal bioactive molecules with an improved effect and less toxicity in order to replace synthetic drugs. Constipation is the most prevalent medical…
- Article
Compression Coating Technique and its Formulation in Circadian Rhythm Activity with Chronotherapeutic Drug Delivery System
Manjunath Pobbathi Nagaraj, Avinash Kumar Seth, Anand Kandkere Ravindra Kumar, Vivekanandan Sundaramurthy
pp. 323–327 · DOI: 10.5530/ijpi.2022.3.54 · Published
Background: Circadian rhythms is a natural process that regulates the sleep wake cycle which is associated with several physiological, biochemical, endocrine, behavioural processes in humans and entrainment to light-dark…
- Article
Inhibition by Ascorbate among Phosphofructokinase-1, Aldolase, Enolase, and Lactate Dehydrogenase in Rabbit Muscle
Anita Ricablanca, Ami Abbott, Fatimata Sonago, Montserrat Garcia, Rachel Primacio, Eric Patten, Mudassar Iqbal Arain, Eduardo Fricovsky
pp. 328–333 · DOI: 10.5530/ijpi.2022.3.55 · Published
Background:These studies examined mutual protective relationships among rabbit muscle aldolase, enolase, phosphofructokinase-1 (PFK-1) and LDH from inhibitions by ascorbate (AA). It was proposed earlier that specific inh…
- Article
Comparisons of Phosphofructokinases-1 from Rabbit, Chicken, and Fish
Patricia Gaitan-Hahn, Anita Ricablanca, Ami Abbott, Jessica Chadwick, Alicia Thomas, Nathalia Cruz, Alice Deng, Leah Ordinanza, Mudassar Iqbal Arain, Eduardo Fricovsky
pp. 334–339 · DOI: 10.5530/ijpi.2022.3.56 · Published
Background: Previous studies suggested that glycogen storage was facilitated by ascorbate inhibition of phosphofructokinase-1 (PFK-1) in resting mammalian muscle; these studies showed that purified PFK-1 from fish or chi…
- Article
Tephrosia purpurea Ameliorates Oxidative and Histological Alterations Induced by Aflatoxin B1 in Rats
Shamli S Gupte, Arti Rathour, Divya Gupta, Richa Soni, Sadhana Shrivastava, Monika Bhaduria, Satendra Kumar Nirala, Shubham Singh, Anjali Sharma, Deepa Yadav, Samrat Rakshit, Sangeeta Shukla
pp. 340–345 · DOI: 10.5530/ijpi.2022.3.57 · Published
Background: Tephrosia purpurea (TP), commonly known as wild indigo, is traditionally used in treatment of splenomegaly. It is an important ingredient of various Ayurvedic medicines used in treatment of liver diseases. Ob…
- Article
Nephroprotective Activity of Ethanolic Extract of Alternanthera sessilis Leaves in Gentamicin-induced Nephrotoxicity in Wistar Albino Rats
V. V. Rajesham, Ruqaiya Jabeen, Mitta Raghavendra, P. Roshan Ali, T. Rama Rao
pp. 346–350 · DOI: 10.5530/ijpi.2022.3.58 · Published
Background:Renal disease is a significant issue of global proportions and renal damage is very prevalent as the kidney has the ability to excrete toxic substances to assess the protective impact of the Ethanolic extract …
- Article
Antidiabetic Activity of an Alkaloid (4a-Methyl-5-(6-Methylhept- 5-En-1-Yl)Octahydro-1H-Cyclopenta[A]Pyridazine) Isolated from Lumnitzera racemosa in Streptozotocin-Induced Diabetic Wistar Rats
Ranjana R, Deepak Kumar Singh, Bhaskar Laxman Jadhav
pp. 351–357 · DOI: 10.5530/ijpi.2022.3.59 · Published
Background: Diabetes mellitus is a metabolic disorder that causes millions of deaths throughout the world every year, and today also its incidence is on the increase. Many antidiabetic drugs are available in the pharmace…
- Article
Evaluation of Diuretic and Laxative Potential of Onosma bracteata Wall.: A Species of the Controversial Drug ‘Gojihva’
Udaykumar Girdharlal Vegad, Devang Jagdishbhai Pandya
pp. 358–362 · DOI: 10.5530/ijpi.2022.3.60 · Published
Background:Gojihva or Gaozaban, an Ayurvedic cum Unani Medicinal plant described with various properties, including diuretic activity. Onosma bracteata Wall. is considered the official species of Gojihva in Ayurveda and …
- Article
Silymarin, Quercetin and Hesperidin Combination Ameliorates Learning and Memory Deficit in 3 Nitro Propionic Acid Induced Rat Model of Huntington’s Disease
Arti Akash Bhimanwar, M M Ghaisas, R V Shete
pp. 363–369 · DOI: 10.5530/ijpi.2022.3.61 · Published
Introduction:Huntington’s disease is considered as the autosomal dominating with progression of neuro-degeneration with decreased cognitive function and behaviour changes. Bioflavonoids promote memory, learning, and cogn…
- Article
L-carnitine Protects Cisplatin Induced Liver Fibrosis in Experimental Animals via Reducing Oxidative and Nitrosative Stress
Vikram Nimbalkar, Niraj Vyawahare
pp. 370–374 · DOI: 10.5530/ijpi.2022.3.62 · Published
Background:The aim of the present study was to examine the protective potential of L-carnitine against Cisplatin-induced liver fibrosis in experimental models. Materials and Methods:The rats were randomly divided into fi…
- Article
Influence of Polygonum minus Aqueous Extract on Monoamine Oxidase-A Transcriptional Activators KLF-11 and SIRT1 Levels in the Hippocampus of Stress-induced Depressed Mice
Muhammad Irfan Bashir, Nur Hidayah Kaz Abdul Aziz, Dzul Azri Mohamed Noor
pp. 375–379 · DOI: · Published
Background: Monoamine oxidase-A (MAO-A) enzyme is responsible for the breakdown of monoamines (serotonin and norepinephrine). MAO-A is also a target to treat the depressive disorders. Kruppel-likefactor11(KLF11) and Sirt…
- Article
The Impact of an Educational Intervention on the Skill of Community Pharmacists in the Use of a Pressurized Metered-dose Inhaler: A Covert Simulated Patient Approach in Pakistan
Sara Shahid, Fahad Ahmed, Amna Bajwa, Muhammad Ans, Anosh Sana, Sameen Abbas, Asma Fareed Khan, Aiman Mahmood, Qandeel Rafi, Shakeel Ahmad, Asifa Anwar, Rabeel Khan, Gul Shahnaz, Asad Majeed Khan
pp. 380–385 · DOI: 10.5530/ijpi.2022.3.64 · Published
Introduction: Metered-dose inhalers are the most widely prescribed and dispensed inhaler devices worldwide for the management of asthma. The present study aimed to access the impact of educational intervention on the com…
- Article
Formulation and Evaluation of Timolol Maleate Proniosomal Gel for Ocular Drug Delivery
Jayatheertha S Lokapur, Prakash S Goudanavar, Arpitha J Lokapur, Ankit Acharya, Sandip A Murtale
pp. 386–390 · DOI: 10.5530/ijpi.2022.3.65 · Published
Introduction:The objective of this task is to succeed with the trial of an ocularly efficient Timolol maleate formulation produced from prolonged proniosomal gel niosomes to get significant therapy for glaucoma. Material…
- Article
Measuring Medicine Prices and Availability of Commonly used Essential Medicines using WHO/HAI Methodology in Hyderabad, India
Sai Latha K, Abhinaya P, Parimala Devi G, Lakshmi PK
pp. 391–395 · DOI: 10.5530/ijpi.2022.3.66 · Published
Objectives:Access to health care is a basic right of population. Essential medicines are those which satisfy the priority of health care needs and intended to be available at all times. Hence prices and availability need…
Case Report
- Article
Congenital Hydrocephalus with Aqueductal Stenosis: A Rare Condition Case Report
Rajeshwari Pasupula, S. Bhanu Uday Sankar, Sreya Kosanam, Ch Naga Priya, Ch Varudhini Devi, Bhimavarapu Sai Deepika
pp. 396–398 · DOI: 10.5530/ijpi.2022.3.67 · Published
Congenital Hydrocephalus is due to buildup of excess cerebrospinal fluid in the brain at birth. Fluid buildup leads to neurological and psychological damages to the child. Aqueductal stenosis means a narrowing the passag…
Letter to the Editor
- Article
Research Tools: Endnote Click (Formerly Kopernio): Access millions of Research Paper PDFs
Mueen Ahmed KK
pp. 399 · DOI: 10.5530/ijpi.2022.3.68 · Published
Endnote Click is a new, free research tool from Clarivate Analytics that allows authors to quickly find and download PDFs of research papers. By indexing the full text of millions of research papers, Endnote Click makes …