Volume 12, Issue 4

· pp. 400–492 · 16 articles

Volume: 12
Issue: 4
Published
Pages: 400–492
Articles: 16
Sections: 2
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article

In this issue

Review Article

Review
Responsible Research in Planning for Animal Experiments – A Mini Review
Leena Rajathy Port Louis, Prithiviraj Nagarajan, Asokan Balakrishnan Ramajayam
pp. 400–402 · DOI: 10.5530/ijpi.2022.4.69 · Published
Animal experiments are routinely carried out worldwide either in educational setups or in research setups. Animal research can be basic or applied, where in the applied research the test compound/drug is tested in animal…
Review
A Guidance on Premarket Pathways for Combination Product in the United States of America
Vaibhav SU, Vedamurthy Joshi, Prakash Goudanvar, Soumik Banerjee, Vinay Prasad S
pp. 403–407 · DOI: DOI: 10.5530/ijpi.2022.4.70 · Published
The Office of combination products OCP, an agency to regulate the combination products under the US Food and Drug Administration (FDA) has released the final guidance on the combination products for its approval which is…
Review
Nutritional Values and Therapeutic Uses of Capra hircus Milk
Gaurav Tiwari, Akanksha Chauhan, Pooja Sharma, Ruchi Tiwari
pp. 408–417 · DOI: 10.5530/ijpi.2022.4.71 · Published
Capra hircus (Goats) are a vital part of the livestock industry because of their ability to adapt to harsh conditions, making them ideal for landless and marginal farmers. The Capra hircus is one of the most prominent op…

Original Article

Article
In silico Toxicity Prediction on Novel Antiobesity Drug Using Cheminformatics Approaches
Kevizano Jacinta Zashumo, V Mathivanan, Hezinglila Grace, D Leelavathi
pp. 418–422 · DOI: 10.5530/ijpi.2022.4.72 · Published
Background:Obesity is a major problem that many individuals suffer presently. Using in silico Tools and Servers, we propose to build a novel chemical drug and validate its oral toxicity effect. Our strategy entails first…
Article
In vitro Evaluation of Antioxidant Property, Chemo-profiling, Elemental Analysis of Morinda umbellata L.
Anushya Sankar, Shanthi Periyasamy, Sownthariya Chandrabalan
pp. 423–429 · DOI: 10.5530/ijpi.2022.4.73 · Published
Background: Morinda umbellata L., commonly called as ‘Manjanatti Kodi’ in Tamilnadu, India, is a rare traditional medicinal plant. The study was aimed to investigate the antioxidant potentiality, phytochemical profiling …
Article
GC-MS Profiling, in vitro Antioxidant and Antimicrobial Activities of Kaempferia parviflora Wall. ex. Baker Rhizome Extract
Rameshor Singh Atom, Shaukat Ali M Shaikh, Kishorjit Maharabam, Rakhi Khunjamayum, Dini Ahanthem, Warjeet Singh Laitonjam, Raghumani Singh Ningthoujam, Amit Kunwar
pp. 430–437 · DOI: 10.5530/ijpi.2022.4.74 · Published
Bakground: Kaempferia parviflora (zingiberaceae family) rhizomes are used for various pharmacological applications. The present study is aimed for putative identification of phyto-constituents in the chloroform extract o…
Article
Development and Evaluation of Polyherbal Formulations for Hepatoprotective Activity
Donthamsetty V Sowmya, Srirama Swarnalatha, Morusu Keerthana, Pothina Devi Guna Sireesha, Maruvajhala Vidyavathi
pp. 438–443 · DOI: 10.5530/ijpi.2022.4.75 · Published
Background: Liver is one of the most important human organs and is a sensitive target for chemicals that modulate biotransformation. The present study aimed to develop a polyherbal formulation in the form of both capsule…
Article
Synthesis, Characterization, Anti-tubercular Evaluation, and Teratogenicity Studies of Novel 5-(4-fluorobenzoyl) tetrahydro benzamidazoquinazoline Derivatives
N Raghavendra Babu, R Subhakar Raju, Narender Malothu, Yenumula Padmavathi
pp. 444–448 · DOI: 10.5530/ijpi.2022.4.76 · Published
Background: The largest infectious agent-related cause of death and the most common disease with a high contagiousness profile is tuberculosis. For the treatment of tuberculosis, various benzimidazole and quinazoline com…
Article
Synthesis of Some Novel (Z)-3-ethylidene-5,7-dimethylthiochroman- 4-one Derivatives and Study of its Monoamine Oxidases Inhibitory Activity
Somesh Kumar Saxena, Om Prakash Agrawal, Ashish Pathak
pp. 449–454 · DOI: 10.5530/ijpi.2022.4.77 · Published
Background:Chroman-4-one, also known as 2,3-dihydro-1-benzopyran- 4-one, is a heterocyclic compound with a benzene nucleus fused to a 2,3-dihydro-g-pyranone ring. The synthesis of chroman-4-one derivatives is a very appe…
Article
Novel Approach for the Cyclic Voltammetric Determination of an Antidepressant Drug (Dosulepin) in Pharmaceutical Formulations
Ram Lal Saini, Seema Parveen, Rajni Bais
pp. 455–461 · DOI: 10.5530/ijpi.2022.4.78 · Published
Background:This research was focused on the development of a quick, simple, precise, and cost-effective voltammetric method for quantifying dosulepin. Materials and Methods:The antidepressant drug (dosulepin) was assesse…
Article
Amalgamation of QbD and Alcohol Induced Dose Dumping Studies on Diltiazem Hydrochloride Modified Release Tablets
PH Viramgama, CD Modi, DJ Patel, AB Chaudhary
pp. 462–469 · DOI: 10.5530/ijpi.2022.4.79 · Published
Background: Alcohol induced dose dumping is a noteworthy question in designing of modified release dosage forms and it led the marketed products withdrawal by regulatory agencies. Diltiazem HCl is a highly watersoluble d…
Article
Development and Characterization of Mupirocin Emulgel for the Treatment of Primary and Secondary Infections in Dry Skin Conditions
Rajashri Namdev Kausdikar, Manish S Kondawr, Fahim J Sayyad
pp. 470–474 · DOI: 10.5530/ijpi.2022.4.80 · Published
Background:Dry skin conditions’ primary and secondary infections can be treated by using mupirocin topically. By overcoming the disadvantages of ointments, creams, and lotions, the goal of the formulation of mupirocin em…
Article
Ionically Cross-linked Pectin-alginate Hydrogel Beads for Prolonged Release of Glibenclamide
Sreejan Manna, Abdul Aziz, Sanchita Das, Manas Bhowmik
pp. 475–478 · DOI: 10.5530/ijpi.2022.4.81 · Published
Background:Glibenclamide is a second-generation sulfonylurea extensively associated with the therapy of diabetes mellitus. A sustained release of the drug in the gastrointestinal tract may aid in maintaining therapeutic …
Article
Caloric Vestibular Stimulation Alleviates the Motor Dysfunctions in a Mouse Model of Parkinson’s Disease
Harini Narayanam, Archana Rajagopalan, Subramani Parasuraman, Parayil Varghese Christapher, Suresh V Chinni
pp. 479–482 · DOI: 10.5530/ijpi.2022.4.82 · Published
Background: Parkinson’s disease (PD) is one of the most common degenerative disorders of the ageing brain. Currently, there is no cure for PD and most of the available treatments only aim to reverse the dopamine deficien…
Article
Comparative Evaluation of Dengue Virus (DENV) Serotypes Infections in Human (Homo sapiens)
Afaf S Alwabli
pp. 483–488 · DOI: 10.5530/ijpi.2022.4.83 · Published
Background:Dengue virus is transmitted by the mosquito species Aedes aegypti and causes dengue fever. The single positive-stranded RNA virus of the family Flaviviridae belongs to the genus Flavivirus. There is four dengu…
Article
Potential Drug Interactions between Antibiotics and Risk of Antimicrobial Resistance: A Database Research Study
Pradeep Battula, Bhupalam Pradeep Kumar
pp. 489–492 · DOI: 10.5530/ijpi.2022.4.84 · Published
Background:When two antibiotics are used at the simultaneously, they interact. The interaction could be either synergistic or antagonistic. However, an antagonistic combination may halt the action of another antibiotic, …