Ionically Cross-linked Pectin-alginate Hydrogel Beads for Prolonged Release of Glibenclamide

ABSTRACT

Background:Glibenclamide is a second-generation sulfonylurea extensively associated with the therapy of diabetes mellitus. A sustained release of the drug in the gastrointestinal tract may aid in maintaining therapeutic range for an extended period of time. Alginate and pectin are two commonly used biopolymers in the field of drug delivery with favourable biodegradation and biocompatibility. Materials and Methods: In the present study, pectin-alginate hydrogel beads were developed for intestinal delivery of glibenclamide. A barium ion (Ba+2) induced ionic gelation technique was employed for synthesising pH sensitive beads by varying the ratio of sodium alginate and pectin. The FTIR study confirmed the compatibility between drugs and polymers. The developed beads were evaluated for scanning electron microscopic study, drug entrapment efficiency (DEE), bead size, swelling ratio, and in-vitro dissolution study. Results:The microscopic images exhibited hemispherical shaped beads with cracked and rough surfaces. The DEE study reported to vary between 78.38 ± 1.17 % and 92.08 ± 0.64 %. The mean size of the bead was found to be 668.81 ± 2.10 μm to 984.62 ± 2.84 μm. A pH dependent swelling was observed, which indicated a restricted water uptake in an acidic medium and an increased water uptake in alkaline pH. The in-vitro dissolution study demonstrated a sustained release of drug with increasing pectin concentration up to 12 h. Conclusion:The study findings reported the successful development of Ba+2 ions cross-linked pectin-alginate hydrogel beads for sustained delivery of glibenclamide.

KEYWORDS

• Barium ion
• Ionic gelation
• pH sensitive bead
• Alginate
• Pectin

Showing references and in-text citations exactly as published.

• DOI10.5530/ijpi.2022.4.81Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPI.

• Article · VOLUME 12, ISSUE 4In silico Toxicity Prediction on Novel Antiobesity Drug Using Cheminformatics ApproachesKevizano Jacinta Zashumo, V Mathivanan, Hezinglila Grace, D Leelavathi · pp. 418–422Original ArticleSame type: Article
• Article · VOLUME 12, ISSUE 4In vitro Evaluation of Antioxidant Property, Chemo-profiling, Elemental Analysis of Morinda umbellata L.Anushya Sankar, Shanthi Periyasamy, Sownthariya Chandrabalan · pp. 423–429Original ArticleSame type: Article
• Article · VOLUME 12, ISSUE 4GC-MS Profiling, in vitro Antioxidant and Antimicrobial Activities of Kaempferia parviflora Wall. ex. Baker Rhizome ExtractRameshor Singh Atom, Shaukat Ali M Shaikh, Kishorjit Maharabam, Rakhi Khunjamayum, Dini Ahanthem, Warjeet Singh Laitonjam, Raghumani Singh Ningthoujam, Amit Kunwar · pp. 430–437Original ArticleSame type: Article
• Article · VOLUME 12, ISSUE 4Development and Evaluation of Polyherbal Formulations for Hepatoprotective ActivityDonthamsetty V Sowmya, Srirama Swarnalatha, Morusu Keerthana, Pothina Devi Guna Sireesha, Maruvajhala Vidyavathi · pp. 438–443Original ArticleSame type: Article