International Journal of Pharmaceutical Investigation
Volume 13, Issue 1
· pp. 1–205 · 27 articles
- Volume
- 13
- Issue
- 1
- Published
- Pages
- 1–205
- Articles
- 27
- Sections
- 3
- ISSN
- Print - 2230-973X, Online -2230-9713
- Journal
- IJPI
In this issue
Review Article
- Review
A Review on Different Solubility Enhancement Techniques of Ticagrelor
Abhishek Srivastava, Mohammad Ahmad Khan, Simrata Bedi, Uma Bhandari
pp. 1–6 · DOI: 10.5530/223097131574 · Published
Ticagrelor is a BCS class IV drug that inhibits platelet action by reversibly binding to the P2Y12 receptor. One of the major challenges faced by the class IV (low solubility, low permeability) drug is the lower dissolut…
- Review
Herbal Bioenhancers with Nanocarriers: A Promising Approach for Oral Peptide Delivery
Indu Raghunath, Marina Koland, Anoop Narayanan Vadakkepushpakath, Lalit Kumar, Sarathchandran Chandra Shekhar Shenoy
pp. 7–13 · DOI: 10.5530/223097131736 · Published
The oral delivery of protein and peptide drugs faces immense challenges due to the harsh gastrointestinal (GI) environment, large molecular size, and low stability. Even though different approaches are employed to delive…
- Review
Clozapine: A Scientific Analysis of Global Publications during 1970-2021
Sandeep Grover, B.M. Gupta, K.K. Mueen Ahmed, Yogindra Singh
pp. 14–21 · DOI: 10.5530/223097130001 · Published
Aim: This study evaluates the research output on Clozapine included in Scopus database during 1970-2021. Materials and Methods:The quantitative and qualitative analysis of publications on “Clozapine” covered in Scopus da…
Original Article
- Article
Cardioprotective and Hepatoprotective Effects of Ixora pavetta and Tecoma capensis Leaf Extracts
Dara Suneeta, YRKV Tirupathi Rao
pp. 22–27 · DOI: 10.5530/223097131566 · Published
Background:Ixora pavetta and Tecoma capensis are two less explored and neglected plants species in medicinal prospective. The flowers bark and root of I. pavetta used as a remedy for cough, anaemia, women urinary problem…
- Article
Optimization of Green Synthesized Black Tea Nanoparticles using Central Composite Design
Sarika Nikam, Shilpa Chaudhari
pp. 28–36 · DOI: 10.5530/223097131651 · Published
Objectives: Traditional method of optimization is lengthy and time consuming while response surface methodology evaluates the effects of multiple factors and their interactions on one or more response variables with fewe…
- Article
Prospective Study on Identification of Risk Factors, Assessment of Respiratory Distress in Pediatrics
Machavarapu Neelima, Yekkala Prathyusha, Mamindla Archana, Thirunagiri Praveen kumar
pp. 37–42 · DOI: 10.5530/223097131669 · Published
Introduction:Respiratory tract infection (RTI) is defined as any upper or lower respiratory tract infectious disease. Globally, respiratory infections are the leading cause of infant and child mortality and a substantial…
- Article
Age-related Variation in TSH Levels in Patients with Down’s Syndrome -A Ten Year Longitudinal Study
Mandar Ambike, Nabilah Kazi, Arun Prasad, Dnyandeo Chopade, Suresh Kondaveeti
pp. 43–47 · DOI: 10.5530/223097131714 · Published
Background: A well-established finding is that thyroid disease is seen more commonly in individuals suffering from Down’s Syndrome than in people without the condition. Patients are at risk from childhood to adulthood. T…
- Article
Adverse Drug Reactions Monitoring in New Patients Admitted to the Cardiac Care Unit in a Tertiary Care Hospital
Paviterjeet Singh, Shweta Singla, Rajiv Mahajan, Rakendra Singh, Manish Kumar Gupta
pp. 48–52 · DOI: 10.5530/223097131715 · Published
Background: Adverse Drug Reactions (ADRs) are amongst the commonly occurring event in the intensive care unit where patients are mostly on the polypharmacy. They affect the quality of life of patients and increase the bu…
- Article
Protective Effect of Arjunakwatha and Arjunasheeta in Paracetamol-induced Kidney Injury in Rat Model
Supriya Bhowmick, Deblina Giri, Meghamala Mandal, Shrabanti Pyne, Pinku Pal, Sanjay Das, Dilip Kumar Nandi, Koushik Das
pp. 53–61 · DOI: 10.5530/223097131728 · Published
Background:Chronic kidney disease is now a global burden with an increased grade of morbidity and mortality due to the unavailability of particular medicines except for high-cost treatments like dialysis or kidney transp…
- Article
Evaluation of DHFR Inhibition and Antimicrobial Activity of Some Newly Synthesized Quinazolin-4(3H)-one Scaffold Coupled with Benzylidene and Ethylidene Amino Motifs
Sunil Harer, Manish Bhatia, Priyanka Sonar
pp. 62–73 · DOI: 10.5530/223097131749 · Published
Objectives:Substituted quinazolin-4(3H)-ones at position-3 with phenyl ring, heterocycles and aliphatic moieties, were reported to impart antimicrobial activities. In light of this, we have attempted to prepare a novel s…
- Article
Development, Optimization and Evaluation of Herbal Patch Formulation for Acne Treatment
Kinjal Patel, Keyur Patel, Maitreyi Zaveri
pp. 74–81 · DOI: 10.5530/223097131792 · Published
Background:More than 85% of young people around the world suffer from acne vulgaris, which is the most prevalent chronic inflammatory skin illness. The study’s objective was to develop a herbal patch formulation containe…
- Article
Synthesis and Pharmacological Evaluation of Novel Quinazoline Derivatives as Potential EGFR Inhibitors for Breast Cancer
Deepak K. Dwivedi, Ram Kishore Agrawal
pp. 82–86 · DOI: 10.5530/223097131793 · Published
Background:Breast cancer is the highest mortality-causing disease among cancers in women and it can be cured by early diagnosis as well as treatment. Epidermal growth factor receptor-2 (HER2) is the prime factor that hel…
- Article
Polymeric Nanocarrier system Bearing Anticancer Agent for the Treatment of Prostate Cancer: Systematic Development and in vitro Characterization
Pritish Kumar Panda, Sanjay K. Jain
pp. 87–93 · DOI: 10.5530/223097131799 · Published
Objectives:Doxorubicin-bearing polymeric (PLGA) nanoparticles (PNPs) were prepared for the treatment of prostate cancer. Materials and Methods:These PNPs were prepared using the solvent evaporation method and characteriz…
- Article
Simultaneous Analysis of Topotecan and Capsaicin by Micellar Liquid Chromatography
Shivani Saraf, Priyanka Pahade, Devashish Bose, Sanjay K. Jain
pp. 94–99 · DOI: 10.5530/223097131802 · Published
Objectives: This study aimed to develop a micellar liquid chromatography-based simultaneous estimation method for the analysis of topotecan and capsaicin. Materials and Methods:The Liquid chromatographic system consisted…
- Article
Site-Specific Delivery of Doxorubicin Using Cell-Penetrating Peptide for Lung Cancer Chemotherapy
Laxmikant Gautam, Suresh P. Vyas
pp. 100–105 · DOI: 10.5530/223097131810 · Published
Recent studies have focused heavily on tumor-oriented nanocarriers mediated by cell- penetrating peptides (CPPs). However, the loss of CPPs in normal tissues and enzymatic degradation in circulation frequently prevented …
- Article
Green Synthesis of Copper Nanoparticles Using Leaf Extract of Ocimum sanctum and its Antimicrobial Activity
Pradnya Zambare, Avinash Survase, Shivangi Kanase
pp. 106–112 · DOI: 10.5530/223097131692 · Published
Objectives:We reported a non-toxic, low-cost and environmentally friendly green synthesis technique for the manufacture of copper nanoparticles (Cu NPs) utilizing Ocimum sanctum (O. sanctum) leaf extract to prevent hospi…
- Article
Related Substances Method Development and Validation of Axitinib, Zanubrutinib and Upadacitinib Using RP-HPLC and its Degradation Products were Characterized by Using LC-MS/MS
Ibrahim Baje Syed, Madhavi Nannapaneni
pp. 113–121 · DOI: 10.5530/223097131696 · Published
Background: Axitinib was used to treat carcinoma of renal cells and Upadacitinib was used to treat rheumatoid arthritis and Zanubrutinib used as an anti cancer medication for mantle cell lymphoma. In the current applicat…
- Article
Anti-manic and Antipsychotic Effects of Withania somnifera Extract in Rodent Model of Bipolar Disorder
Mohammad Rashid Iqbal, Satish Kumar Sharma
pp. 122–128 · DOI: 10.5530/223097131721 · Published
Aim: The present study was to investigate the effects of WSE improve cognitive, behavioral and mood disorders in animal models of bipolar disorder. Materials:Animals were divided into six groups each group contain 6 wist…
- Article
Computational Studies to Identify Potential Inhibitors Targeting the DprE1 Protein in Mycobacterium tuberculosis
Bashir A Sheikh, Basharat A Bhat, Masood A Rizvi, Zahoor Ahmad, Abdullah Almilaibary, Mustfa Alkhanani, Manzoor A Mir
pp. 129–138 · DOI: 10.5530/223097131750 · Published
Background:DprE1, which is a flavoenzyme, is very important for cell wall biosynthesis in Mycobacterium tuberculosis (Mtb) and for the pathogenesis, virulence, lethality, and stress resistance of the host. Drug-resistant…
- Article
Role of Novel Polyherbal Formulations in Secondary Complications like Peripheral Neuropathy in Streptozotocin-Induced Diabetic Wistar Rats
Vikash , Gupta, Mohan Lal Kori
pp. 139–148 · DOI: 10.5530/223097131485 · Published
Background:Diabetes becomes a chronic disease when glucose constantly remains high and uncontrolled. As time goes off, it may gradually develop acute or chronic associated complications. Diabetic neuropathy is one of the…
- Article
Development and Optimization of Solid Lipid Nanoparticle Based Gel of Desoximetasone
Tularam Barot, Urja Patel, Shruti Barot, Hitesh Dalvadi
pp. 149–154 · DOI: 10.5530/223097131840 · Published
Background:The present study enlightens to enhance the residence time and prolonged release of the desoximetasone by incorporating it into solid lipid nanoparticles (SLN), prepared by hot melt homogenization process. The…
- Article
Formulation and Evaluation of Oro-dispersible Bromhexine Hydrochloride Granules Using Sachelac-80
Anita P Ayre, Shilpa A Gajbhiye
pp. 155–161 · DOI: 10.5530/223097131733 · Published
Background: Patients with sudden episodes of allergic or epileptic attacks and those who are mentally ill are less non-compliant and there is a lack of effective therapy. The need for delivering therapy at a very fast pa…
- Article
Therapeutic Potential of Dragea volubilis Leaf Extract against Scopolamine-induced Memory Impairment in Young and Aged Mice
Amit Sharma, Naresh Gill
pp. 162–172 · DOI: 10.5530/223097131525 · Published
Background: Treating neurological disorders is still a major challenge, especially diseases like alzheimer's. Dragea volubilis is a wonder herb with many pharmacological activities like neuroprotective, antioxidant, anti…
- Article
Formulation, Evaluation, and Stability testing of Polyherbal Antidiabetic Capsules
Navjot Kaur, Shailesh Sharma
pp. 173–178 · DOI: 10.5530/223097131753 · Published
Background: The phytoconstituents of single plants are inadequate to produce the desired efficacy and results. The combination of various herbal drugs in a specific proportion will improve the therapeutic efficacy by sim…
- Article
Design and Development of Deflazacort pH Transition Injectable in-situ Implant for Rheumatoid Arthritis
Ashwathi V Nair, Sindhoor SM, Prashant Nayak, Natasha Naval Aggarwal, Mohammed Gulzar Ahmed, Prajitha Biju
pp. 179–186 · DOI: 10.5530/223097131727 · Published
Introduction:Rheumatoid arthritis is a chronic inflammatory disorder causing painful swelling and damaging various body systems. Deflazacort is a drug of choice for treatment, but it exhibits lower mineral corticoid acti…
- Article
A Cross-sectional Survey to Understand the Public Attitude towards Attributes of COVID-19 Vaccine in the Chhattisgarh State of India
Pradip Chaurasia, Shrikant R Inchulkar, Gyanenedra Singh Baghel, Mukund Lal Naik, Lowkesh Chandravanshi, Satyavati Rathiya, Muhammed Thareekh Bin Bashir, Rashmi Sahu, Manish Minj, Nagendra Singh Chauhan, Awanish Kumar, Prashant Kumar Gupta
pp. 187–200 · DOI: 10.5530/223097130002 · Published
Background and Objectives: This survey is conducted to understand the attitude of the population towards vaccination for COVID-19. Perception regarding COVID -19 vaccination such as efficacy, duration of protection, etc …
Continuing Education
- Article
Effective Scientific Writing Series: Part I
Mueen Ahmed KK, Mohammed Yunus, Parasuraman S
pp. 201–205 · DOI: 10.5530/223097130003 · Published
A scientific manuscript is a formal document that is submitted for publication in a scientific journal. The format of a scientific manuscript varies depending on the journal, but usually includes an abstract, introductio…