Novel Approach for the Cyclic Voltammetric Determination of an Antidepressant Drug (Dosulepin) in Pharmaceutical Formulations
Ram Lal Saini1, Seema Parveen1, Rajni Bais1
- 1Department of Chemistry, Jai Narain Vyas University, Jodhpur, Rajasthan, INDIA.
Received: 24-05-2022; Revised: 18-06-2022; Accepted: 12-08-2022.
Volume 12, Issue 4 · pp. 455–461 · PUBLISHED · DOI: 10.5530/ijpi.2022.4.78
ABSTRACT
Background:This research was focused on the development of a quick, simple, precise, and cost-effective voltammetric method for quantifying dosulepin. Materials and Methods:The antidepressant drug (dosulepin) was assessed in pharmaceutical formulations using square wave voltammetric (SWV) and Differential pulse voltammetric (DPV) techniques at a glassy carbon potentiometric working electrodes (GCE). Results:Dosulepin demonstrated a single clear and sharp cathodic peak in the applied potential -0.7 to -0.75 V versus Ag/AgCl/KCl reference electrode. Results from cyclic voltammetry, DPV, and SWV revealed one reduction wave with a peak potential of -0.7 V at pH 7. The proposed method’s excellent sensitivity was demonstrated by the obtained LOD of 7.686 x10- 8mol L-1and a LOQ of 2.589x10-7mol L-1bulk were by applying Differential Pulse Voltammmetry method. On other hand a LOD of 1.735x10-7mol L-1and a LOQ of 5.785x10-7mol L-1bulk dosulepin were achieved by applying the Square Wave Voltammetry method. Conclusion:The suggested methods might be recommended for usage in quantitative detection, product testing, and research laboratories.
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Saini, R. L., Parveen, S., & Bais, R. (). Novel Approach for the Cyclic Voltammetric Determination of an Antidepressant Drug (Dosulepin) in Pharmaceutical Formulations. International Journal of Pharmaceutical Investigation, 12(4), 455–461. https://doi.org/10.5530/ijpi.2022.4.78