jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
International Journal of Pharmaceutical InvestigationNOW IN
Article

In-vitro Antioxidant and Antitumor Activity of Dihydropyrimidine-2(1-H)-thione Derivatives with Carbazole Moiety

Purushotham KN1★, Bevinahalli Ramesh1, Thoppalada Yunus Pasha1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Nagamangala, Mandya, Karnataka, INDIA.

CORRESPONDENCE

Purushotham KN

Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Nagamangala, Mandya, Karnataka, INDIA.

8acup@gmail.com

Received: 15-10-2022; Revised: 10-11-2022; Accepted: 21-11-2022.

Volume 13, Issue 2 · pp. 255–260 · PUBLISHED · DOI: 10.5530/ijpi.13.2.035

View on IJPI original site ↗

ABSTRACT

Aim:Prepared a series of molecules called Dihydropyrimidine- 2( -H)-thione of carbazole to evaluate antioxidant and antitumor activity. Materials and Methods: Compounds from DTP- to DTP- were prepared and subjected for Spectral analysis like infrared, H NMR, and Mass spectroscopy. Further evaluated antioxidant property of molecules using DPPH free radical scavenging method and analyzed the antitumor activity by MTT assay. Results:The molecule DTP-4 (4-(9H-carbazol-9-yl)-6-(13-hydroxyphenyl)-5,6-dihydropyrimidine- 2( H)-thione) exhibit the spectral values i.e, Mass, m/z: 137 .28, 66.45; IR (KBr) νmax , cm− : 134 22 (NH Str), 13567(O-H); H NMR (MHz, δ): ( 5H, Ar-H) 8.2213-7.2 9, ( H, N-H) . 29, ( H, O-H) 2.213 and DTP-6: 4-(9H-carbazol-9-yl)-6-(4-Dimethylamino-phenyl)-5,6-dihydropyrimidine- 2( H)-thione Mass value of m/z: 1398.213, 66.29; IR (KBr)vmax , cm− : 134 9 (NH Str), (Ar C=S); H NMR (MHz, δ): ( 5H, Ar-H) 8. 28-7. 2 , ( H, N-H) . 292, (6H, -N-(CH13 ) 2 )13.49 - 2.79 . Conclusion: Among all of those prepared molecules, DTP-4, which includes the functional group (13-OH) ortho-hydroxy, has an IC52 value of 2.13 2 µm against the Jurkat T cell line while compound DTP-26, which contains the functional group 4-dimethylamino, exhibits an IC52 value of 25.139 µm against the HeLa cell line.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    KN, P., Ramesh, B., & Pasha, T. Y. (). In-vitro Antioxidant and Antitumor Activity of Dihydropyrimidine-2(1-H)-thione Derivatives with Carbazole Moiety. International Journal of Pharmaceutical Investigation, 13(2), 255–260. https://doi.org/10.5530/ijpi.13.2.035