Volume 14, Issue 3

Arram Madhavi, Medidi Srinivas, Niraj Gupta

pp. 822–832 · DOI: 10.5530/ijpi.14.3.92 · 2024

Objectives A simple and sensitive analytical method was developed to quantify the vericiguat in tablet formulation. Materials and Methods The analyte was separated on a Kromacil C column (250 mm×4.6 mm×5 μm particle size…

Daneshwari Bhusannavar, Bhuvneshwari Sharannavar, Nithyananda Sastry Darbha, Shailendra Suryawanshi, Sarvesh Patil, Parixit Bhandurge

pp. 833–842 · DOI: 10.5530/ijpi.14.3.93 · 2024

Background The primary objective of this study is to pioneer a novel UV spectrophotometric method, designed with simplicity and high sensitivity to accurately measure both Rutin and Curcumin simultaneously. Rutin has a t…

Sankaranarayanan Vijayalakshmi, Somaskandan Subramanian, Sellappan Malathi

pp. 843–850 · DOI: 10.5530/ijpi.14.3.94 · 2024

Background 5-Fluorouracil (5-FU) is a chemotherapy drug commonly used in the treatment of colon cancer. There is a significant drive to mitigate the limitations of 5-fluorouracil while maintaining its therapeutic potency…

Shamjetshabam Babeeta Chanu, Laishram Rupachandra Singh, Sanjenbam Kunjeshwori Devi, Sanasam Yaiphabi, Birson Ingti, Taranga Jyoti Baruah

pp. 851–856 · DOI: 10.5530/ijpi.14.3.95 · 2024

Background Tyrosinase is an enzyme involved in the production of L-DOPA. To look for novel tyrosinase inhibitors, we investigated the non-protein fraction from the sericin extract of the silk cocoon shell of Antheraea pr…

Balaji Rathnam Kamalarathnam, Vadivelan Panneerselvam Karthik, Parvathreddy Sowmya, Kavitha Ramasamy

pp. 857–872 · DOI: 10.5530/ijpi.14.3.96 · 2024

Background Lung cancer is the most reported cancer worldwide and therapeutic resistance poses a major challenge. This in silico molecular docking and molecular dynamic simulation study was carried out to evaluate the bin…

Narayanamma Lakshmi Mudunuru, Kalyan Chakravarthy Janjanam, Rajeswari Saripilli

pp. 873–880 · DOI: 10.5530/ijpi.14.3.97 · 2024

Background Diabetic mellitus is the oldest and most commonly occurring disease known as a life-threatening disease in all age groups from the past 3000 years ago, which is taking away the liveliness from the persons and …

Adhithyanarayana Bhat Kodangodlu Subhramanya, Prashant Nayak, Harshitha Ramalingappa, Harish Kachcharavi Hemanna, Prerana Shetty

pp. 881–887 · DOI: 10.5530/ijpi.14.3.98 · 2024

Background This study presents a comprehensive study on applying the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use Q1A R2 guideline for conducting stability tests on …

Megha Ganesh Bhise, Lima Patel, Khyati Patel

pp. 888–902 · DOI: 10.5530/ijpi.14.3.99 · 2024

Background 3D printing, also known as additive manufacturing, is a rapidly advancing technology in the life sciences sector. Several countries, including the USA, Canada and Singapore, have established regulations for 3D…

Mrunalini Devi Kotagiri, Shiva Kumar Gubbiya

pp. 903–914 · DOI: 10.5530/ijpi.14.3.100 · 2024

Background Alzheimer’s Disease (AD) is the most prevalent cause of dementia globally and its frequency increases as the world’s population ages. AD is one of the largest healthcare issues of the 21st century as the prima…

Krantisinha Hanumant Randive, Meenaxi Maruti Maste, Amolkumar Ashok Kempwade

pp. 915–927 · DOI: 10.5530/ijpi.14.3.101 · 2024

Background Nebivolol hydrochloride (NBV) is a highly selective beta-adrenoceptor antagonist belonging to the third generation of beta-blockers. It is primarily utilized in the management of cardiovascular conditions. Sin…

Kavin Panneerselvam, Subramanian Somaskanthan

pp. 928–934 · DOI: 10.5530/ijpi.14.3.102 · 2024

Background Miconazole nitrate, a BCS class II drug which is used for treatment of fungal infections. To minimize the disadvantages of sticky creams and ointments and their tendency to rub off, an intelligent dosage regim…

Mahek Shah, Lajja Patel, Shailvi Shah, Khushali Parekh, Mohit Shah, Dhaivat Parikh, Tejal Mehta

pp. 935–945 · DOI: 10.5530/ijpi.14.3.103 · 2024

Background Gout is a chronic disease caused by the accumulation of uric acid crystals in joints, resulting in sudden pain, stiffness, and swelling. Febuxostat (FBX), a xanthine oxidase inhibitor, is commonly used to trea…

Mohini Rawat, G. Gnanarajan

pp. 946–958 · DOI: 10.5530/ijpi.14.3.104 · 2024

Background The most popular and well-designed nano-carriers for drug delivery targeting are liposomes. In order to overcome barriers to cellular and tissue uptake and increase medication bio-distribution to target areas …

Vaishnavi Vilas Galande, Mahesh Hari Kolhe, Aditi Rajendra Khatal, Rohit Jaysing Bhor, Payal Sopan Gawali, Pratibha Sudhakar Bhalerao, Manjusha Pandharinath Mhaske

pp. 959–965 · DOI: 10.5530/ijpi.14.3.105 · 2024

Aim Vildagliptin and Dapagliflozin in fixed-dose combination is used for treatment of Type II Diabetes Mellitus. The key objective of the current research work is to develop a new stability-indicating UHPLC method for th…

Pallavi Patil, Sandhya Bagde, Kalyani Kalad, Varsha Pawar, Neha Shegokar, Sakshi Bharti

pp. 966–979 · DOI: 10.5530/ijpi.14.3.106 · 2024

Background Studies have indicated that atazanavir is prone to degradation in environments with high levels of acidity and oxidative stress. However, the drug demonstrated stability when exposed to basic, neutral, photoly…

Megha Hegde, Saurav Raj, Dhananjay Tikadar, Sanatkumar Bharamu Nyamagoud, Suhana Nawab, Muskan Padgutti, Musharraf Chandsha

pp. 980–982 · DOI: 10.5530/ijpi.14.3.107 · 2024

Background The side effect of Parkinsonism due to chlorpromazine emerged three years after its approval for public use, leading to the understanding that conventional anti-psychotics could induce various Extrapyramidal S…